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Trimethylglycine

Trimethylglycine Dosage & Review

Trimethylglycine Review Trimethylglycine was originally referred to as betaine since it was discovered in sugar beets during the 19th century. It was the first betaine discovered and is an organic compound that occurs in plants such as in broccoli, spinach, grains, and shellfish. Generally, Trimethylglycine serves its purpose by decreasing high levels of the amino acid homocysteine, which is a risk factor for having heart diseases and stroke. In addition to that, Trimethylglycine may help with the treatment of Homocystinuria, a hereditary condition that causes homocysteine to accumulate in the blood at toxic levels. This condition has been associated with excessive tiredness, abnormal bone development, weak bones, and blood clots. On the other hand, researches have found that Trimethylglycine may have hepatoprotective properties and could prevent fatty liver deposits due to chronic alcohol use, insufficient protein intake, obesity, and diabetes. It is also known as Betaine, TMG, Glycine betaine, oxyneurine, lycine.
Trimethylglycine
Also Known Betaine, TMG, Glycine betaine, oxyneurine, lycine
Description Trimethylglycine was originally referred to as betaine since it was discovered in sugar beets during the 19th century. It was the first betaine discovered and is an organic compound that occurs in plants such as in broccoli, spinach, grains, and shellfish. Generally, Trimethylglycine serves its purpose by decreasing high levels of the amino acid homocysteine, which is a risk factor for having heart diseases and stroke. In addition to that, Trimethylglycine may help with the treatment of Homocystinuria, a hereditary condition that causes homocysteine to accumulate in the blood at toxic levels. This condition has been associated with excessive tiredness, abnormal bone development, weak bones, and blood clots. On the other hand, researches have found that Trimethylglycine may have hepatoprotective properties and could prevent fatty liver deposits due to chronic alcohol use, insufficient protein intake, obesity, and diabetes.
Typical Dose It has been found that the lowest effective dose for Trimethylglycine is 500mg taken throughout the course of the day.
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Benefits and Effectiveness

  • Anaerobic Exercise - Neutral [1]
  • Blood Glucose - Neutral [2]
  • Blood Pressure - Neutral [3]
  • Cortisol - Decrease [4]
  • Fat Mass - Neutral [5]
  • Fatigue - Neutral [6]
  • Fecal Weight - Neutral [7]
  • Growth Hormone - Neutral [8]
  • HDL-C - Neutral [9]
  • Heart Rate - Neutral [10]
  • Homocysteine - Decrease [11]
  • Hydration - Neutral [12]
  • LDL-C - Increased [13]
  • Lactate Production - Neutral [14]
  • Lean Mass - Neutral [15]
  • Liver Enzymes - Decrease [16]
  • Muscular Endurance - Neutral [17]
  • Power Output - Neutral [18]
  • Total Cholesterol - Increased [19]
  • VO2 Max - Neutral [20]
  • Serum Folate - Neutral [21]

Trimethylglycine Dosage

It has been found that the lowest effective dose for Trimethylglycine is 500mg taken throughout the course of the day.

Side Effects

Trimethylglycine has been shown to produce some minor side effects such as nausea, diarrhea, and upset stomach.

Wiki Last Updated: 2016-02-12
^1 http://www.ncbi.nlm.nih.gov/pubmed/19250531
^1 http://www.ncbi.nlm.nih.gov/pubmed/22471891
^1 http://www.ncbi.nlm.nih.gov/pubmed/18438230
^2 http://www.ncbi.nlm.nih.gov/pubmed/22976217
^2 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^2 http://www.ncbi.nlm.nih.gov/pubmed/20642826
^2 http://www.ncbi.nlm.nih.gov/pubmed/18438230
^3 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^4 http://www.ncbi.nlm.nih.gov/pubmed/22976217
^5 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^5 http://www.ncbi.nlm.nih.gov/pubmed/22471891
^5 http://www.ncbi.nlm.nih.gov/pubmed/21744011
^6 http://www.ncbi.nlm.nih.gov/pubmed/21747291
^6 http://www.ncbi.nlm.nih.gov/pubmed/21747291
^6 http://www.ncbi.nlm.nih.gov/pubmed/19250531
^7 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^7 http://www.ncbi.nlm.nih.gov/pubmed/22471891
^7 http://www.ncbi.nlm.nih.gov/pubmed/21744011
^7 http://www.ncbi.nlm.nih.gov/pubmed/19824078
^8 http://www.ncbi.nlm.nih.gov/pubmed/22976217
^9 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^9 http://www.ncbi.nlm.nih.gov/pubmed/20978525
^9 http://www.ncbi.nlm.nih.gov/pubmed/15916468
^10 http://www.ncbi.nlm.nih.gov/pubmed/22080324
^10 http://www.ncbi.nlm.nih.gov/pubmed/18438230
^11 http://jn.nutrition.org/content/133/12/4135.full
^11 http://www.ncbi.nlm.nih.gov/pubmed/15522136
^11 http://www.ncbi.nlm.nih.gov/pubmed/12730412
^11 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^12 http://www.ncbi.nlm.nih.gov/pubmed/20642826
^12 http://www.ncbi.nlm.nih.gov/pubmed/18438230
^13 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^13 http://www.ncbi.nlm.nih.gov/pubmed/20978525
^13 http://www.ncbi.nlm.nih.gov/pubmed/15916468
^14 http://www.ncbi.nlm.nih.gov/pubmed/22976217
^14 http://www.ncbi.nlm.nih.gov/pubmed/22080324
^14 http://www.ncbi.nlm.nih.gov/pubmed/20642826
^15 http://www.ncbi.nlm.nih.gov/pubmed/22471891
^15 http://www.ncbi.nlm.nih.gov/pubmed/21744011
^16 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^16 http://www.ncbi.nlm.nih.gov/pubmed/11569700
^16 http://benthamscience.com/open/journal/render-fulltext.php?articleID=TOTRANSMJ-3-1
^16 http://www.ncbi.nlm.nih.gov/pubmed/19824078
^17 http://www.ncbi.nlm.nih.gov/pubmed/22080324
^17 http://www.ncbi.nlm.nih.gov/pubmed/19250531
^17 http://www.ncbi.nlm.nih.gov/pubmed/20642826
^18 http://www.ncbi.nlm.nih.gov/pubmed/22080324
^18 http://www.ncbi.nlm.nih.gov/pubmed/21747291
^18 http://www.ncbi.nlm.nih.gov/pubmed/19250531
^18 http://www.ncbi.nlm.nih.gov/pubmed/20642826
^19 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^19 http://www.ncbi.nlm.nih.gov/pubmed/20978525
^19 http://www.ncbi.nlm.nih.gov/pubmed/15916468
^20 http://www.ncbi.nlm.nih.gov/pubmed/18438230
^21 http://www.ncbi.nlm.nih.gov/pubmed/15522136
^21 http://www.ncbi.nlm.nih.gov/pubmed/12730412
^21 http://www.ncbi.nlm.nih.gov/pubmed/12399266
^21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488898/

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