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Sunifiram

Sunifiram Dosage & Review

Sunifiram Review Sunifiram is a synthetic derivative of Piracetam, and is believed to be 1000 times more potent. It is no longer in the Racetam family instead, it now belongs to the Ampakines classification due to its absence of the pyrrolidine backbone and it acts as an AMPA agonist. Since Sunifiram (DM-235) belongs to the ampakine family since it acts as an AMPA agonist that exerts anti-amnesiac properties. It modulates the production of Glutamate, one of the most important neurotransmiiter of the brain responsible for the communication, maintenance, and reguation of connections between synapses. With this mechanism, Sunifiram enhances brain performance by improvement in memory recall and in learning new concepts. Also, Sunifiram is cholinergis thus, increasing the levels of Acetylcholine in the brain contributing to an enhanced cognitive performance. With similar actions as Nefiracetam, it holds promise as a cognitive enhancer but is relatively understudied currently. Sunifiram is categorized under Ampakines. It is also known as DM-235.
Sunifiram
Also Known DM-235
Description Sunifiram is a synthetic derivative of Piracetam, and is believed to be 1000 times more potent. It is no longer in the Racetam family instead, it now belongs to the Ampakines classification due to its absence of the pyrrolidine backbone and it acts as an AMPA agonist. Since Sunifiram (DM-235) belongs to the ampakine family since it acts as an AMPA agonist that exerts anti-amnesiac properties. It modulates the production of Glutamate, one of the most important neurotransmiiter of the brain responsible for the communication, maintenance, and reguation of connections between synapses. With this mechanism, Sunifiram enhances brain performance by improvement in memory recall and in learning new concepts. Also, Sunifiram is cholinergis thus, increasing the levels of Acetylcholine in the brain contributing to an enhanced cognitive performance. With similar actions as Nefiracetam, it holds promise as a cognitive enhancer but is relatively understudied currently.
Typical Dose 0.08-0.16mg/kg
Stacks
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Benefits and Effectiveness

Sunifiram Dosage

0.08-0.16mg/kg

Side Effects

The most common sid effect associate dwith Sunifiram usage is headache but can easily be eliminated with the addition of choline. Some other side effects include nausea, restlessness, anxiety, and increased perspiration.

Sunifiram Review: What is Sunifiram?

Sunifiram, the New Potent Nootropic

Sunifiram is one of the newest nootropics today. But, one should not belittle this supplement. Here’s why. Developed only in the year 2000 and known as 1-benzoyl-4-propanoylpiperazine, Sunifiram may be compared to that of Noopept. This is because both supplements are regarded to be 1000 times more potent than the ever famous Piracetam. It serves to give you a significant upgrade in your cognitive functions by increasing your ability to learn, improving recall of both short and long term memories, enhancing focus and attention span, and increasing your mental energy to sustain you for your mentally demanding tasks.

Although Sunifiram’s structure is similar to Piracetam, it is much more powerful and serves to enhance cognitive functions through several ways. It has been regarded to be a very helpful study aid when both used alone or combined in a stack. Let us now know what Sunifiram has to offer and how it works inside our body to deliver such potent results.

How does Sunifiram work?

1. Sunifiram as an Ampakine

The primary mechanism of action through which Sunifiram enhances cognition is its property as an Ampakine compound. Ampakine refers to a class of compounds that facilitate the transmission of nerve impulses in the brain (1). By being an AMPA agonist, this means it binds to glutamate and boosts glutaminergic activity. Glutamate is a neurotransmitter known to be a major mediator of excitatory signals in our Central nervous system and is associated with normal brain functioning specifically that of cognition, learning and memory (2). It is also involved in brain metabolism and synaptic plasticity. Because of Sunifiram’s influence on the glutaminergic system, there will be enough levels of Glutamate that will support and provide an enhanced cognitive functioning. In contrast to high Glutamate levels, insufficient supply will lead to impaired cognitive abilities. This includes poor attention span, poor ability to learn, and difficulty remembering information.

Also by being an Ampakine, Sunifiram may play a role in the enhancement of an individual’s long term potentiation. Long term potentiation refers to the long-term strengthening of the synapses within the brain. These synapses are responsible for the efficient communication and signal transmission between neurons (4). When these synapses are strengthened, neuronal communication is improved. As a result, there will be a more efficient and effective transfer of impulses to and from the brain.

In addition to the cognitive benefits mentioned earlier, ampakines like Sunifiram also act as mild stimulants. It provides a significant boost in mental energy. As a result, it creates a more goal-oriented activity. The users would feel motivated in doing their tasks as well as improving their focus and concentration. They will be less distracted from both internal and external stimuli. With this benefit that Sunifiram provides, it would be a great study aid for students and professionals who are in mentally demanding situations.

With Sunifiram being an ampakine, the result will be an enhanced cognitive function through an increased learning capacity, faster processing speed, and improved memory recall. It would also lead to higher productivity levels due to an improvement in concentration, focus, and motivation.

2. Sunifiram and the Cholinergic system

Another mechanism through which Sunifiram enhances one’s cognitive abilities is its influence on the Cholinergic system. Just like that of the Racetams, it serves to increase the levels of Acetylcholine in the brain. And as we all know, Acetylcholine is the neurotransmitter responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (3). Because Sunifiram increases the levels of Acetylcholine the result will be an enhanced cognition. This includes increased learning ability, enhanced memory formation, storage and recall, improved attention span and focus, and faster processing speed.

Moreover, some researches show that Sunifiram also acts to improve the communication between the two hemispheres of the brain. This type of communication is then referred to as transcallosal communication. As a result, this type of communication can improve one’s problem solving skills and creative thinking.

Sunifiram Reviews

Since Sunifiram is a fairly new nootropic, there have been a limited number of researches and clinical studies yet involving human subjects. However aside from the cognitive benefits it provides, some people report additional benefits from Sunifiram supplementation. One benefit is an improvement in mood. Some users experience anxiolytic benefits as well as an improved ability to respond to stress. This generally leads to lesser anxiety and promotion of a good mood. Secondly, some people have noted an improvement in perception. External stimuli such as visual and auditory stimuli are improved. The colours appear brighter and sounds appear to be more distinctive. On the other hand, Sunifiram also exhibits aphrodisiac-like effects. Although the exact mechanism of action of Sunifiram with regards to libido is not yet fully understood, it appears to increase sex drive in both males and females. Some theories suggest that it may increase blood flow to the genitals and pleasure centers as well as a heightened perception to touch or tactile stimulus.

Sunifiram Safety and Side Effects

Sunifiram is generally considered to be safe to use and is well-tolerated when taken at the recommended dosages. However, we should take note that this is a fairly new drug and researches and reports about its side effects on human subjects are yet to be discovered. Some reported Sunifiram side effects from users are fairly mild and this includes headaches, nausea, indigestion, restlessness, insomnia, jitters, and increased perspiration.

How much Sunifiram do I need daily?

It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Sunifiram, how much of it do we really need each day? Since Sunifiram is a potent nootropic, a much lower dose is already enough to produce desired effects. People typically use a daily Sunifiram dose of between 5 mg to 8 mg. This daily dose may be divided and taken into multiple administrations if you wanted a more constant and sustained release of effects. Taking a dose of 10 mg may give you stimulant effects like Adderall. However, daily dose should not exceed 10 mg to avoid adverse effects of the supplement.

When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. Just like Sunifiram, you might want to start with a daily dose of 3 mg or 4 mg and increase it gradually over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.

Where can I buy Sunifiram?

You can purchase Sunifiram online. Drug is available over the counter and thus, does not require prescription from a doctor. Although we may find it a bit more expensive than the other nootropics available at the market today, we should take note that Sunifiram is highly potent and thus needs a much lower dosage to achieve optimal benefits. Buy Sunifiram and experience a significant step up in your cognitive function.

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References:
  1. http://www.oxforddictionaries.com/us/definition/american_english/Ampakine
  2. http://neurotransporter.org/glutamate.html
  3. http://www.chemistryexplained.com/A-Ar/Acetylcholine.html
  4. http://thebrain.mcgill.ca/flash/i/i_07/i_07_m/i_07_m_tra/i_07_m_tra.html
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Results & Experiences

Daily Dosage # Stacks
5.00 mg 1
0.16 mg 1
Purpose # Stacks Effectiveness
Cognitive confusion 1
Unknown
Can't tell
None
Slight
Moderate
Major
Loss of energy 1
Unknown
Can't tell
None
Slight
Moderate
Major
Memory problems 1
Unknown
Can't tell
None
Slight
Moderate
Major

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Wiki Last Updated: 2016-02-13