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Selegiline

Selegiline Dosage & Review

Selegiline Review Selegiline is a monoamine oxidase inhibitor (MAOI) that specifically influences MAO-B however with larger doses, it also inhibits MAO-A. This is a drug that is approved in various forms to treat neurodegenerative disorders such as dementia, early-stage Parkinson's disease and also mood disorders such as major depression. It is very similar to amphetamines in structure, and some believe it acts as a neuroprotective agent. It has also been tested for the management of attention-deficit disorder and may have nootropic properties. Selegiline is categorized under Dopaminergics.
Selegiline
Also Known
Description Selegiline is a monoamine oxidase inhibitor (MAOI) that specifically influences MAO-B however with larger doses, it also inhibits MAO-A. This is a drug that is approved in various forms to treat neurodegenerative disorders such as dementia, early-stage Parkinson's disease and also mood disorders such as major depression. It is very similar to amphetamines in structure, and some believe it acts as a neuroprotective agent. It has also been tested for the management of attention-deficit disorder and may have nootropic properties.
Typical Dose 1.25mg
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Benefits and Effectiveness

Selegiline Dosage

1.25mg

Side Effects

Reported mild side effects related to Selegiline usage include difficulty sleeping, dizziness, nausea and diarrhea. More serious side effects recorded include arryhtmia, difficulty breathing and serious headaches.

Selegiline Review: What is Selegiline?

What is it? Why do people use it?

Dopamine functions as a neurotransmitter inside the brain; a chemical released by neurons (nerve cells) to send signals to other nerve cells. Selegiline plays a role in increasing the levels of dopamine. Low levels of dopamine could lead to a condition called Parkinson’s disease. Selegiline is used in combination with many other medications to treat Parkinson’s disease. It is also known to breakdown some chemicals inside the brain that are often imbalanced in individuals who are suffering from depression.

Selegiline transdermal can be used in treating major depressive disorders in adults. Studies have shown that many negative effects can occur if Selegiline is taken in combination with certain drugs. People who have tumors in their adrenal gland and are using certain other drugs are advised to avoid using this type of medication. It is important that you inform your physician or any qualified medical professional about all the drugs that you have been currently using, and any drugs that you decide to stop using and to use in the future in order to avoid danger.

Experts claim that Selegiline should not be given to children below 12 years old since various side effects could occur. It is highly recommended that you note any reactions caused by this medication such as changes in mood, and report it to your physician. Many young individuals have thought of committing suicide when fist taking anti-depressants. Do not take Selegiline if you have taken fluoxetine (Sarafem, Prozac, and many more) within the past five weeks or experience any allergic reactions after using it.

What are the benefits of Selegiline?

Selegiline is known to be beneficial in patients suffering from Parkinson’s disease, especially in terms of motor skills. It can help relieve tremors and allow the patient to perform usual activities of daily living in a less challenging manner. Unlike many MAO inhibitors, users of Selegiline did not experience rise in blood pressure. L-Dopa or levodopa is used alone or in combination with carbidopa to treat Parkinson's disease. However, these medications can cause some side effects like sleep problems (insomnia), dizziness, mild nausea, drowsiness, dry mouth, heart burn, loss of appetite and many more. Taking Selegiline helps Parkinson’s disease patients decrease the amounts and frequency of levodopa medications, which leads to fewer side effects associated when taking these medications.

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On the other hand, the United States Food and Drug Administration continue to reject the findings regarding the benefits of Selegiline in Parkinson’s disease. There are only few evidences available that can prove this medication’s effectiveness in enhancing the cognitive function in non-Parkinson’s patients. There are various other nootr opic supplements that can boost the production of dopamine inside the brain which are already popular and were greatly proven for this purpose.

Long-term Effects of Selegiline

The long term effects of Selegiline in patients with Parkinson’s disease are not known. Studies show that Selegiline could help individuals with Parkinson’s disease since this condition results from decreased levels of dopamine inside the brain, secondary to a rapid breakdown of dopamine. By inhibiting the substance that destroys dopamine, Selegiline could help treat this disease. It likewise increases the possibility that more dopamine could pass through the blood brain barrier and enters the brain, thus, allowing certain parts of the brain to control mood, memory, and thought in order to promote a normal function.

In the year 2006, Selegiline was approved by the Food and Drug Administration as a transdermal treatment for major depressive disorders. Many clinical trials reported that it does not cause any negative reactions and is an effective treatment. Some findings show that Selegiline was a better option as compared to monoamine oxidase inhibitors (MAO inhibitors) since it causes lesser negative effects when taken at a small dose, and does not require the same dietary restrictions as with some other medications of the same type.

Nowadays, research studies have been conducted to investigate other possible benefits of this medication, as a help to individuals to stop smoking marijuana and tobacco, and as a treatment for attention deficit hyperactivity disorder or ADHD. However, there is not, as yet, any valid scientific evidence of this medication’s effectiveness in these uses.

Is it safe? What are the side effects of Selegiline?

Depending upon the person’s age, condition, or sensitivities, Selegiline could cause both minimal and severe side effects. Some of the minimal side effects caused by this medication include dizziness, sleep disturbances, diarrhea, and nausea. Some of the more serious side effects include troubled breathing, cardiac arrhythmia, and severe headaches. It is highly recommended that you contact your doctor at once on the off chance that you experience these serious side effects.

Experts suggest that Selegiline should not be taken in combination with Selective serotonin reuptake inhibitors (SSRIs) fluoxetine, or with the opioid analgesic pethidine. It is still not know if it is safe when taken together with other to monoamine oxidase inhibitors. Some people use Selegiline in combination with illicit narcotics such as 3,4-methylenedioxy-methamphetamine (MDMA), this practice is considered to be very dangerous. Selegiline is not recommended for healthy individuals who intend to use this medication daily in order to enhance their focus and mental energy. A variety of natural nootropics are available in the market today that can help you attain these goals in a safer manner and with few negative effects.

What is the appropriate dosage for Selegiline?

Selegiline is available in both transdermal and oral forms. The transdermal forms are used to treat depression; on the other hand, the oral forms are used to treat Parkinson’s disease.

Similar to those that are used by individuals who want to quit smoking, the transdermal form of Selegiline is delivered in a form of patch. It can be placed directly to the skin, attached to the thigh, torso, and upper arm. The patch should be changed every day, and it will continuously release medication into the circulation throughout the day. The common dose for this form is 6 mg per day. However, there are instances wherein your physician decides to give you a higher dose.

The oral form of Selegiline can be taken as either a dissolving tablet or a capsule. The dissolving tablets are taken only once per day, before breakfast, and should not be taken with and fluid or food. The patient should avoid drinking anything for about 5 minutes before and after taking it. On the other hand, capsules are taken 2 times per day, with both breakfast and lunch.

It is advisable to take oral disintegrating tablet at a smaller dose. Your doctor will gradually increase it after 6 weeks. The usually prescribed dosage for Parkinson’s disease patients is 1.25 mg per day, and gradually increased to 2.5 mg per day after 6 weeks.

References:
  1. http://www.naturalremedies.org/selegiline/
  2. http://www.selegiline.com/
  3. http://www.everydayhealth.com/drugs/selegiline
  4. http://www.rxwiki.com/selegiline
Reviewer: Kathleen R. RN, PT
Wiki Last Updated: 2016-02-14
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