Pregnenolone known otherwise as P5 is an endogenous steroidal hormone that is popularly used as a mood enhancement and focus supplement. It has been used to treat Alzheimer's disease and to enhance memory, and help repair traumatic injuries to the head. Dr. Flood states, “Pregnenolone is the most potent memory enhancer yet reported", he works for the Geriatric Research Education and Clinical Center (1)
Pregnenolone is an important hormone, it acts as a precursor for the production, development and synthesis of other chemicals and hormones such as androgens, estrogens, progesterones, glucocorticoids, mineralocorticoids, and even neuroactive steroids. Also, it is a precursor to DHEA and cortisol. P5 is synthesized from cholesterol primarily in adrenal glands and can also occur in the retina of the eyes, brain, skin, liver, ovaries, and testicles. Supplementation of P5 has been increasing in popularity since as we get older, the levels of Pregnenolone inside our bodies decrease as well.
When taken orally, P5 can easily cross the blood brain barrier. There, it works by regulating proper balance of the levels of hormones equally in both gender's. Neurosteroids such as Pregnenolone affect synaptic functioning by regulating the transmission of messages from one neuron to another, thus leading to enhancement in neuronal communication and better cognitive processes. It specifically modulates the NMDA receptors – these receptors respond to Glutamate and regulates the creation of new synapses in neurons.
Cognitively speaking, Pregnenolone is used in Long Term Potentiation. Which leads to improved memory formation and memory retention, it enhances an individual's mood, focus, motivation, learning capacity and learning ability, long term memory storage capability, and even boosts energy levels.
Studies have found that Pregnenolone poses the capability to be neuroprotective. It speeds up the repair of damaged neurons and nerves and enhances myelination as well. As a result, conduction of nerve impulses and signals are enhanced while maintaining the health and integrity of the individual nerve cells. It has also been found that Pregnenolone boosts an individual's immunity thus relieving fatigue while restoring energy levels. In addition, the neurosteroid also acts by slowing down the effects of premature aging.
In the medical field P5 has been found to be beneficial to individuals suffering from Osteoarthritis and Rheumatoid Arthritis by relieving the symptoms of the said conditions. Additionally, P5 may be used to alleviate mood disorders, relieve symptoms such as: clinical depression and heal some pain linked to fibromyalgia. In addition to that, some people supplement Pregnenolone as a treatment for allergic reactions, for detoxification purposes, Multiple Sclerosis, Lupus, prostate problems, seizures, and for strengthening the heart. Researchers have also looked upon Pregnenolone to be a potential treatment for Schizophrenia. (1) (2)
1. Proper Pregnenolone dosage and frequency
It is crucial for a drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. The recommended dosage of this supplement is about 5 mg to 20mg a day. Another way of adminstering it could be to dose it twice daily, once in the morning and another dose later on near afternoon. Since it has mild stimulating effects, avoid taking it late at night so as to not have it interfere with your sleep regimen.
When starting with any new drug or supplement, it would be best to start off with a low dose to see how you respond and then gradually increasing it over time. Just like in the case of P5, you may want to start with a daily dose of 5mg. If you are familiar with its benefits and how it affects your body personally, you may increase your daily dosage over time. You might also want to consider consulting your doctor or healthcare provider first since a person's condition and health status may play a role in it's efficacy.
For hormones such as Pregnenolone, it is suggested one take low doses over a short period of time with frequent breaks. An acceptable intake would only be 2 to 3 days a week.
2. Pregnenolone Safety and Associated Side Effects
The use of Pregnenolone has been considered safe and well tolerated for general consumption. However, some side effects have been reported and so the supplement should be used cautiously and should not be taken on a long term basis. Adverse effects of Pregnenolone are directly linked to the dosage taken. When taken at low doses, Pregnenolone can reduce stress and anxiety however, high doses of which can produce irritability and anxiety. Low doses of the drug can help with one's sleep however, high doses can result in the opposite effect such as insomnia and night sweats. In addition, Pregnenolone may also produce steroid-like side effects such as anger, irritability, overstimulation, negative mood changes, facial hair growth and even heart palpitations in some individuals. Since Pregnenolone converts into DHEA and then to testosterone, then to DHT, it can increase balding to those who are predisposed. It also has an effect on androgens, it can produce acne and oily skin. Moreover, when Pregnenolone is used in a long term basis, it can cause withdrawal symptoms for some. This includes anxiety, restlessness and nervousness. Some people also become fatigued and paranoid. In this case, it is recommended to slowly reduce the dose for 10 mg a day instead of abruptly stopping the supplement. (2)
3. Pregnenolone Contraindications & Interactions
It is also important to know that there are some special considerations associated with Pregnenolone use. Since there is not enough evidence on Pregnenolone's safety among pregnant and breast feeding women, it would be best to avoid its use with this specific population. Also, some people are contraindicated to Pregnenolone use due to their specific conditions and other medications that could interact with the drug. For individuals suffering from Prostate cancer, they should avoid taking Pregnenolone since the drug may increase testosterone levels and worsen the condition. This also holds true for people suffering from breast and ovarian cancer. Since Pregnenolone can increase estrogen levels, it may also worsen their condition. In relation to that, some estrogen medications that may interact with Pregnenolone include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol and among many others. Progestin, a group of hormones can also interact with Pregnenolone since it can result in too much hormones in the body thus increasing both the effects and side effects of the hormone pills. Other hormone sensitive conditions that are also contraindicated to Pregnenolone use include uterin cancer, endometriosis, and uterine fibroids. (2)
4. Stacking Pregnenolone
Pregnenolone is commonly with DHEA. If you wanted to have a more significant boost in your cognitive function, you may also stack Pregnenolone with other potent nootropics. Learn more about these two: Noopept benefits, Phenylpiracetam benefits.
You can purchase Pregnenolone online as it is considered a dietary supplement.Buy Pregnenolone here and see if you experience a variety of its cognitive and health benefits. Do however consult a doctor before starting.
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