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Polygala Tenuifolia

Polygala Tenuifolia Dosage & Review

Polygala Tenuifolia Review Polygala tenuifolia or Senega is a plant wherein its root is used as medicine in the traditional Chinese practice because of its ability to improve memory and protect against cognitive ailments. Although limited human evidence suggests Polygala tenuifolia cannot improve memory, but many claim that it improves spatial awareness and organization. Moreover, it has been used for the treatment of inflammation of the throat, nose, and chest and for lung conditions including asthma, chronic bronchitis, and emphysema. Also, it acts as an expectorant by loosening phlegm and making it easier to cough up. This is due to the mechanism that Polygala Tenuifolia irritate the stomach lining, which causes production of larger amounts of lung secretion. It is also known as Yuan Zhi, Chinese Senega, Herbe au Lait, Klapperschlangen, Laitier, Milkwort, Mountain Polygala, Polygala, Polygala de Sénéca, Polygala de Virginie, Polygala Glomerata, Polygala japonica, Polygala Root, Polygala Reinii, Polygala Sénéca, Polygala senega, Polygalae Radix, Polygala tenuifolia, Racine de Polygala, Racine de Serpent à Sonnettes, Radix Polygalae, Rattlesnake Root, Senaga Snakeroot, Seneca, Sénéca, Seneca Snakeroot, Senega, Senega Snakeroot, Seneka, Snake Root.
Polygala Tenuifolia
Also Known Yuan Zhi, Chinese Senega, Herbe au Lait, Klapperschlangen, Laitier, Milkwort, Mountain Polygala, Polygala, Polygala de Sénéca, Polygala de Virginie, Polygala Glomerata, Polygala japonica, Polygala Root, Polygala Reinii, Polygala Sénéca, Polygala senega, Polygalae Radix, Polygala tenuifolia, Racine de Polygala, Racine de Serpent à Sonnettes, Radix Polygalae, Rattlesnake Root, Senaga Snakeroot, Seneca, Sénéca, Seneca Snakeroot, Senega, Senega Snakeroot, Seneka, Snake Root
Description Polygala tenuifolia or Senega is a plant wherein its root is used as medicine in the traditional Chinese practice because of its ability to improve memory and protect against cognitive ailments. Although limited human evidence suggests Polygala tenuifolia cannot improve memory, but many claim that it improves spatial awareness and organization. Moreover, it has been used for the treatment of inflammation of the throat, nose, and chest and for lung conditions including asthma, chronic bronchitis, and emphysema. Also, it acts as an expectorant by loosening phlegm and making it easier to cough up. This is due to the mechanism that Polygala Tenuifolia irritate the stomach lining, which causes production of larger amounts of lung secretion.
Typical Dose 100mg
Stacks
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Benefits and Effectiveness

  • Memory - Neutral [1]
  • Working Memory - Increased [2]
  • Verbal Fluency - Neutral [3]

Polygala Tenuifolia Dosage

100mg

Side Effects

Long term use of Polygala Tenuifolia is considered unsafe and potential side effects include nausea and vomiting, diarrhea, dizziness, and stomach irritation.

Polygala Tenuifolia Review: What is Polygala Tenuifolia?

Poygala Tenuifolia is a short herb with purple flowers. It has a big name, yuan zhi in Chinese, which means high aspirations. This is one of the 50 fundamental herbs that is widely used in Chinese medicine because of its ability to provide protection to the brain. Polygala Tenuifolia is known by its sedative, cognitive enhancement, antipsychotic, and antidepressant effects. According to one research the uses a randomized, double-blind, placebo-controlled, parallel-group study, Polygala Tenuifolia can improve memory in healthy adults. Another study suggests that Polygala Tenuifolia increases the production of nerve growth factor (NGF) in astrocytes.

In spite of the fact that Polygala tenuifolia supplementation can improve cognitive ability in geriatric individuals, it has constrained impact physically fit individuals. Utilization of Polygala tenuifolia can enhance spatial association and recognition, but it could not enhance short-or long-term memory. Significantly more research is expected to figure out whether Polygala tenuifolia should be considered as a Nootropic.


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Preparation of the Root Extract of Polygala tenuifolia

A 500-gram dried fruit extract of Polygala tenuifolia is soaked with 75 percent ethanol for 4 hours in a boiling water. This procedure is done twice and the ethanol solution was concentrated under a vacuum.

How to make Polygala root and spine date seed congee?

First, cook decoction with 10g polygala roots and 10g spine date seeds. As soon as you are done, filter the decoction, then cook congee with 50 grams’ rice and the filtered decoction. It is good that you eat this before going to sleep.

Polygala root and walnut milk

The procedure is to cook 10g polygala roots and 20g walnuts with 150g water for 30 minutes. After that, filter the decoction, then mix it with 50g milk and add sugar to sweeten. Eat once daily.

History of Polygala Tenuifolia

Polygala tenuifolia (otherwise called Polygala root) is thought to be a remarkable herb that can empower the sleep process. Accepted to relax the soul and calm the heart, Polygala tenuifolia is good in facilitating to ease restlessness and anxiety.

By discharging repressed emotions and relaxing the body, rest may turn out to be all the more fulfilling. In traditional medicine, this herb was known as the "will strengthener," because clients asserted it improves creative thinking, enhance dreaming, and manifested ideas.

How does Polygala Tenuifolia grow?

A length of 9 to 12 inches of smooth, leafy and round stems grow from Polygala. It is considered as a perennial branching root. Its leaves are smooth, with bright green colors on the surface, and is either scattered or alternated. This herb does not have a bad smell, rather it has a fresh smell that resembles green winter (this fragrance is actually 0.1% methyl salicylate). Triterpenoid saponins is considered to be the active ingredient of this herb.

What are the benefits of Polygala Tenuifolia?

Interactions with Cancer Metabolism

Lungs: Studies suggest that extracts from Polygala tenuifolia can also be useful in treating certain types of cancer since the polysaccharides isolated from Polygala tenuifolia has cytotoxic effects in some cancer cells, and was found to have most potent effects in lung adenocarcinoma.

Ovaries: Water-soluble polysaccharide from the roots have been found to be effective in mice with ovarian cancer cells with ten to forty mg/kg IP injections of polysaccharides. Another study has proven this by showing the same outcomes in vitro in a human ovarian cancer cell line.

Inflammation and Immunolo

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perennial branching root. Its leaves are smooth, with bright green colors on the surface, and is either scattered or alternated. This herb does not have a bad smell, rather it has a fresh smell that resembles green winter (this fragrance is actually 0.1% methyl salicylate). Triterpenoid saponins is considered to be the active ingredient of this herb.

What are the benefits of Polygala Tenuifolia?

Interactions with Cancer Metabolism

Lungs: Studies suggest that extracts from Polygala tenuifolia can also be useful in treating certain types of cancer since the polysaccharides isolated from Polygala tenuifolia has cytotoxic effects in some cancer cells, and was found to have most potent effects in lung adenocarcinoma.

Ovaries: Water-soluble polysaccharide from the roots have been found to be effective in mice with ovarian cancer cells with ten to forty mg/kg IP injections of polysaccharides. Another study has proven this by showing the same outcomes in vitro in a human ovarian cancer cell line.

Inflammation and Immunology

Macrophages: Tenuifoliside A, a phenylpropanoid confined from Polygala tenuifolia has been appeared to have strong mitigating properties in macrophages, recommending that it might be valuable for the treatment of inflammatory disorders.

Virology: Polygala tenuifolia was found to have some positive effects in rodents by increasing the production of antibodies when combined with vaccine.

Interactions with Organ Systems

Liver: The ethalonic extracts of Ploygala tenuifolia that allows lipid accumulation in liver cells in vitro can also activate the anti-lipogenic pathways. However, there is not enough evidence to support this theory.

Interactions with Oxidation

Superoxide: Study of rats show that the Oligosaccharide esters isolated from Polygala tenuifolia is capable of increasing increase superoxide dismutase (SOD) in rat models of aging and amnesia. Some studies suggest that Polygala tenuifolia can also increase SOD activity in the brain after oral ingestion.

Sexuality and Pregnancy

Seminal Properties: It is known that Polygala tenuifolia, when applied directly to sperm, can have potent spermicidal effects. However, there no studies that could support its effectiveness on fertility with oral ingestion.

Interactions with Medical Conditions

Alzheimer's Disease: Tenuigenin, a substance obtained from Polygala tenuifolia root extracts, is a potent BACE1 inhibitor in vitro, known to decrease the production of Aβ in some vitro models. The hallmark of Alzheimer’s disease is the increase in secretion of amyloid beta peptide Aβ, which causes plaque formation in the brain. However, there are only a few animal studies about the effectiveness of Polygala tenuifolia extracts in treating Alzheimer’s disease.

Parkinson's Disease: In a study of mice, even a small dose of Polygala tenuifolia could guard against oxidative stressors that could lead to Parkinson’s disease. This is due to the triterpenoid content of the root extract.

Other effects of Polygala tenuifolia

Treats dysphoria, palpitations due to fright, restlessness, insomnia and amnesia: Primarily entering the heart and kidneys, polygala root cannot just disperse the heart-qi to such a degree as to calm mental anxiety, it additionally enacts the stream of the kidney-qi to such a degree as to upgrade the emotional soundness and enhance memory, so it is an effective herb for the rebuilding of the coordination between the heart and the kidneys, as well as enhancing emotional stability.

Coughs with profuse sputum: Polygala tenuifolia is helpful in treating coughs with difficulty in expectorating thick sputum and profuse phlegm. It can help eliminate phlegm and reduce coughing.

Epilepsy and mania secondary to mental confusion caused by phlegm: Polygala root could not just eliminate phlegm, but could also relieve mental confusion, that is why it is also used to treat epilepsy and clonic convulsions following the attacks of phlegm in the heart, as well as mania secondary to mental confusion caused by excessive phlegm production.

Pain and swelling of the breasts and other pyogenic infections: Polygala tenuifolia can be used to treat various types of carbuncle and cellulitis. Being so intense as to be cleansing thus warm as to be clearing, polygala root can dig away stagnated qi and blood to such a degree as to reduce inflammations. There are different ways to apply polygala tenuifolia. For external use, it can be blended with a liquid for application onto the affected part. For internal use, it can be ground into powder and taken with yellow wine.

Anti-Aging Effects: One experiment on aged rodents show that Polygala Tenuifolia has anti- aging effects. The best period in administering the medication is thirty days.

What are its negative effects? And what precautions should you consider when taking this herb?

Despite of all the listed positive effects, there some things that you should consider when taking Polygala Tenuifolia. It would be ideal if you look for the counsel of a skilled botanist in the event that you need to utilize this herb, or any herb, securely. On the off chance that you take this herb for a drawn out stretch of time, you might need to consider using the honey-fried version, or bringing with licorice root, as this will shield your stomach from its drying impacts. Likewise, on the off chance that you have a past event of gastritis, or peptic or duodenal ulcers, then this herb is not a decent decision. This herb is a diuretic, so ensure you have great liquid and electrolyte consumption. Lastly, Polygala Tenuifolia empowers uterine compression, thus, in case you are pregnant and you are prepared to have an infant, then this herb could be useful, however in the event that you are pregnant and you are not prepared to have a child, then hold off.

Polygala tenuifolia should be used with caution. It should be avoided by people who are suffering from gastric ulcers and gastritis, which is an inflammation of the mucous membrane of the stomach. Prolonged use of this herb could lead to vomiting, diarrhea, nausea, and gastrointestinal irritation.

Because Polygala Tenuifolia is drying in nature, it is important that people who are experiencing heat symptoms and hot phlegm should be careful when taking it.

What is the recommended dosage for Polygala Tenuifolia?

It is important to keep in mind that supplements and natural products are not always safe and could cause some negative effects in your body, therefore, dosages can be important. There are several factors to consider about the dosage of Polygala tenuifolia, such as the person’s age, health, and several other conditions. At this point, there is no available guideline of the proper dosage of this herb. It is vital that you should consult your physician or pharmacist and follow relevant directions of the product labels in order to be safe.

References:

  1. https://en.wikipedia.org/wiki/Polygala_tenuifolia
  2. http://www.webmd.com/vitamins-supplements/ingredientmono-679- senega.aspx?activeingredientid=679&activeingredientname=senega
  3. https://trackmystack.com/supplements-Polygala-Tenuifolia#side_effects
  4. http://www.mdidea.com/products/new/new09802.html
  5. http://traditionalherb.org/chinese-herbs/polygala-root-yuan-zhi/
Reviewer: Kathleen R. RN, PT
Wiki Last Updated: 2016-02-12
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^1 http://www.ncbi.nlm.nih.gov/pubmed/19429065
^1 http://www.ncbi.nlm.nih.gov/pubmed/19699261
^2 http://www.ncbi.nlm.nih.gov/pubmed/19429065
^3 http://www.ncbi.nlm.nih.gov/pubmed/19699261

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Daily Dosage # Stacks
300.00 mg 2
100.00 mg 1
150.00 mg 1
Commonly Paired With # Stacks
Alpha GPC 5
L-Theanine 4
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Vitamin D 4

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