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Phosphatidylserine

Phosphatidylserine Dosage & Review

Phosphatidylserine Review Phosphatidylserine is considered a phospholipid membrane that is found in every cell of the body and it promotes healthy cellular signaling. This has been used in the treatment for ADD, ADHD and other bipolar disorers while there is some evidence suggesting that it may lower risk of developing dementia or cognitive impairment among the elderly. Also, some believe that it may contain neuroprotective properties, while others suggest better studies need to be conducted before any claims can be verified or disproven. It is thought that phosphatidylserine could raise levels of cognitive enhancing neurotransmitters like acetylcholine and dopamine thus, improving memory and attention. Phosphatidylserine is categorized under Nutrients. It is also known as PS, D-Serine.
Phosphatidylserine
Also Known PS, D-Serine
Description Phosphatidylserine is considered a phospholipid membrane that is found in every cell of the body and it promotes healthy cellular signaling. This has been used in the treatment for ADD, ADHD and other bipolar disorers while there is some evidence suggesting that it may lower risk of developing dementia or cognitive impairment among the elderly. Also, some believe that it may contain neuroprotective properties, while others suggest better studies need to be conducted before any claims can be verified or disproven. It is thought that phosphatidylserine could raise levels of cognitive enhancing neurotransmitters like acetylcholine and dopamine thus, improving memory and attention.
Typical Dose 300mg (For the treatment of Alzheimer's disease and other age-related memory impairment, a dose of 100mg of phosphatidlyserine taken 3 times daily is recommended.)
Stacks
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Benefits and Effectiveness

  • Anaerobic Exercise - Increased [1]
  • Attention - Increased [2]
  • Blood Pressure - Neutral [3]
  • Cognition - Increased [4]
  • Cognitive Decline - Decrease [5]
  • Cortisol - Neutral [6]
  • Fatigue - Decrease [7]
  • Free Testosterone - Neutral [8]
  • Heart Rate - Neutral [9]
  • Inflammation - Neutral [10]
  • Memory - Increased [11]
  • Muscle Damage - Neutral [12]
  • Stress - Decrease [13]
  • Working Memory - Increased [14]


Phosphatidylserine Dosage

300mg (For the treatment of Alzheimer's disease and other age-related memory impairment, a dose of 100mg of phosphatidlyserine taken 3 times daily is recommended.)

Side Effects

Phosphatidylserine is generally safe to use and well-tolerated however, potential side effects include insomnia and stomach upset.

Phosphatidylserine Review: What is Phosphatidylserine?

How Do We Benefit From Phosphatidylserine?

As a phospholipid compound, Phosphatidylserine contains a number of vital components that can benefit one’s overall health. This includes amino acids and both the omega-3 and omega-6 fatty acids. Amino acids are the building blocks of life and are combined to form proteins needed by our body (2). On the other hand, omega-3 and omega-6 fatty acids play a vital role in the integrity of our cell membranes as well as precursors to different bodily functions especially that of the cardiovascular system (1). Phosphatidylserine supplements were first derived from the brain cells of cows. However due to some issues associated with mad cow disease, some have resorted to soy and cabbage derivatives of Phosphatidylserine (3). At the present, the current production of Phosphatidylserine supplements use soy as their main source. Now, how does Phosphatidylserine really work inside our body? And what are the health benefits that we can obtain from this supplement? Let us now know what Phosphatidylserine has to offer and see for yourself why supplementing of which is a good decision.

What are the benefits of Phosphatidylserine and its mechanism of action?

One thing we should know about Phosphatidylserine is that it has the ability to easily cross the blood brain barrier thus, delivering its results faster and more efficiently. Once in the brain, it then serves to influence a series of processes. It influences a series of neurotransmitters as well as some of our body’s processes.

One of the key mechanisms through which Phosphatidylserine works is that it helps our brain metabolize glucose. Moreover, it helps release and bind with neurotransmitters such as Acetylcholine. This in turn, increases the activity of Acetylcholine and as we all know, Acetylcholine is the neurotransmitter responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (6). Because Phosphatidylserine increases the activity of Acetylcholine, it may result in an enhanced cognition. This includes improved attention span and focus, and faster processing speed.

Aside from Phosphatidylserine’s influence on the cholinergic system, it also positively influences the dopaminergic system. Dopamine levels in the brain are raised and as we all know, Dopamine is the neurotransmitter responsible for an individual’s memory and learning capabilities, attention, pleasurable reward, behavior and cognition, and most especially for mood and sleep (5). With an increased level of this neurotransmitter, there will be a significant improvement in one’s mood and cognitive abilities. It may also be of great help to deal efficiently with stress, anxiety, depression, and even signs of OCD or Obsessive Compulsive Disorder, ADHD and ADD.

Moreover, studies have shown that Phosphatidylserine increases the number of receptor sites located in the synapses. As a result, there would be an enhanced communication from one neuron to another. It can even increase cell membrane fluidity both in healthy neurons and in neurons previously damaged. Because of this, Phosphatidylserine may reduce age-related cognitive impairment and cognitive decline. It may also be used as a protection from factors associated with memory loss and senile dementia.

Phosphatidylserine also pose to have some key benefits to active individuals. This is especially true for athletes involved in weight training, cycling, golf, and endurance running. Since Phosphatidylserine contains amino acids needed for protein building, it may improve muscle recovery as well as in preventing muscle soreness. In this way, athletes can train harder and can significantly improve their physical performance. In a study conducted, athletes who took Phosphatidylserine over the given duration of the study have showed significant difference. They had lesser muscle soreness compared to the placebo group, had lower Cortisol levels, and had reduced Creatine Kinase levels which indicates reduced muscle damage (8). Because of this benefit that Phosphatidylserine has, active individuals have considered it to be a part of their pre workout or post workout diet.

How much Phosphatidylserine do I need to take daily?

It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Phosphatidylserine, how much of it do we really need each day? Generally, the recommended dosage for Phosphatidylserine is 100 mg administered three times a day. This dosage is also true for the treatment of Alzheimer’s disease and other cognitive impairments. However, some users take a dose between 100 mg to 1, 200 mg daily. This then may be divided and taken into multiple administrations within the day if you wanted to have a more constant and sustained release of benefits.

When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.

Can I stack Phosphatidylserine with other supplements?

Yes, stacking Phosphatidylserine with other nootropics and supplements would be a great idea. In this way, your daily needs and preferences would be achieved. For example if you wanted to have a great recovery stack after your intense physical activities, then you might want to stack Phosphatidylserine with Whey Protein, Creatine, or BCAAs. With this, you will have a strong back up to help sustain the recovery of your muscles as well as increase the progress of your physical performance.

On the other hand if you wanted to have a more significant boost in your cognitive performance, you might want to stack Phosphatidylserine with the potent nootropics today. You might want to consider Pramiracetam, Noopept, Phenylpiracetam, and among many others.

Having a thorough understanding of the drugs you wanted to have in a stack is important because some drugs might not go well with the others. Stacking supplements greatly depends on your needs and personal preferences however, it would be best to consult your doctor or healthcare provider first.

Phosphatidylserine Safety and Side Effects

The use of Phosphatidylserine is generally considered safe to use and is well tolerated. In fact, this supplement has been regarded to be on the list of FDA’s GRAS or generally regarded as safe. However, some users may experience some Phosphatidylserine side effects especially when taken at doses over 300 mg. This includes gastrointestinal problems, headaches, and insomnia. These adverse effects are typically mild but may require you to lower your daily dose in order to prevent these side effects.

Where can I buy Phosphatidylserine?

You can purchase Phosphatidylserine online. Drug is available over the counter and thus, does not require prescription from a doctor. Buy Phosphatidylserine now and experience a variety of its health benefits.

References:
  1. http://www.eufic.org/article/en/artid/The-importance-of-omega-3-and-omega-6-fatty-acids/
  2. https://www.nlm.nih.gov/medlineplus/ency/article/002222.htm
  3. http://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/phosphatidylserine/faq-20057764
  4. http://www.webmd.com/vitamins-supplements/ingredientmono-992-phosphatidylserine.aspx?activeingredientid=992&activeingredientname=phosphatidylserine
  5. http://www.news-medical.net/health/Dopamine-Functions.aspx
  6. http://www.chemistryexplained.com/A-Ar/Acetylcholine.html
  7. http://www.phosphatidylserine.net/blog/sports.html
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^1 http://www.ncbi.nlm.nih.gov/pubmed/16394955
^2 http://www.ncbi.nlm.nih.gov/pubmed/23495677
^3 http://www.ncbi.nlm.nih.gov/pubmed/21103034
^4 http://www.ncbi.nlm.nih.gov/pubmed/22017963
^4 http://www.ncbi.nlm.nih.gov/pubmed/21103034
^4 http://www.ncbi.nlm.nih.gov/pubmed/20523044
^5 http://www.ncbi.nlm.nih.gov/pubmed/21103034
^5 http://www.ncbi.nlm.nih.gov/pubmed/11842880
^5 http://www.karger.com/Article/Abstract/107142
^5 http://www.ncbi.nlm.nih.gov/pubmed/1633433
^6 http://www.ncbi.nlm.nih.gov/pubmed/22017963
^6 http://www.ncbi.nlm.nih.gov/pubmed/16394955
^6 http://www.ncbi.nlm.nih.gov/pubmed/16960523
^6 http://www.ncbi.nlm.nih.gov/pubmed/1325348
^7 http://www.ncbi.nlm.nih.gov/pubmed/22017963
^7 http://www.ncbi.nlm.nih.gov/pubmed/16394955
^8 http://www.ncbi.nlm.nih.gov/pubmed/22017963
^9 http://www.ncbi.nlm.nih.gov/pubmed/21103034
^9 http://www.ncbi.nlm.nih.gov/pubmed/18616866
^10 http://www.ncbi.nlm.nih.gov/pubmed/16960523
^11 http://www.ncbi.nlm.nih.gov/pubmed/11201936
^11 http://www.ncbi.nlm.nih.gov/pubmed/20523044
^11 http://www.ncbi.nlm.nih.gov/pubmed/11842880
^12 http://www.ncbi.nlm.nih.gov/pubmed/16960523
^13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217563/
^13 http://www.ncbi.nlm.nih.gov/pubmed/18616866
^14 http://www.ncbi.nlm.nih.gov/pubmed/23495677

No article available.

Comparisons [ top]

Versus ComparisonArmodafinil (Nuvigil) vs PhosphatidylserineRitalin (Methylphenidate) vs PhosphatidylserineModafinil (Provigil) vs Phosphatidylserine
Attention | | |
Cognition | | |
Fatigue | | |
Working Memory | | |
Memory | | |

Results & Experiences

Daily Dosage # Stacks
100.00 mg 10
50.00 mg 4
200.00 mg 3
300.00 mg 2
150.00 mg 2
250.00 mg 1
2.00 g 1
75.00 mg 1
1000.00 mg 1
500.00 mg 1
Duration # Stacks
5 days 1
Purpose # Stacks Effectiveness
Fatigue 1
Unknown
Can't tell
None
Slight
Moderate
Major
Inability to handle stress (bad stress reactions) 1
Unknown
Can't tell
None
Slight
Moderate
Major
Memory and cognition problems 1
Unknown
Can't tell
None
Slight
Moderate
Major
Inattention 1
Unknown
Can't tell
None
Slight
Moderate
Major
Commonly Paired With # Stacks
Fish Oil 19
Alpha GPC 18
Vitamin D 17
Vinpocetine 16
AcetyLcarnitine 16
Magnesium 15

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Wiki Last Updated: 2016-02-16