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Phosphatidylcholine

Phosphatidylcholine Dosage & Review

Phosphatidylcholine Review This is a substance that can be found within Lecithin extracts and is classified as a cholinergic thus increasing Choline levels necessary for overall brain health. Phosphatidylcholines are found within every cell of the human body and are considered essential for proper functioning and are a major component for biological membranes, most specifically cell membranes. Although some scientists have thought that this supplement may slow aging and improve brain functioning among those with neurodegeneration, there remains insufficient evidence to make any significant claims. Further research must be conducted before we assume any benefit or non-benefit. Phosphatidylcholine is categorized under Cholinergics. It is also known as PC, Lipotherapy, Phosphatidyl Choline, Phospholipid, Phospholipide, Phospholipon, Polyenylphosphatidylcholine, Polyénylphosphatidylcholine.
Phosphatidylcholine
Also Known PC, Lipotherapy, Phosphatidyl Choline, Phospholipid, Phospholipide, Phospholipon, Polyenylphosphatidylcholine, Polyénylphosphatidylcholine
Description This is a substance that can be found within Lecithin extracts and is classified as a cholinergic thus increasing Choline levels necessary for overall brain health. Phosphatidylcholines are found within every cell of the human body and are considered essential for proper functioning and are a major component for biological membranes, most specifically cell membranes. Although some scientists have thought that this supplement may slow aging and improve brain functioning among those with neurodegeneration, there remains insufficient evidence to make any significant claims. Further research must be conducted before we assume any benefit or non-benefit.
Typical Dose 2.6g choline via 34g phosphatidylcholine
Stacks
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Benefits and Effectiveness

Phosphatidylcholine Dosage

2.6g choline via 34g phosphatidylcholine

Side Effects

It is generally considered safe but can cause irritation, swelling, redness, itching, burning

Phosphatidylcholine Review: What is Phosphatidylcholine?

Many choline sources are out at the market today and one of them is Phosphatidylcholine. But, how does this supplement differ from all the other sources? And what is its similarity to them? Phosphatidylcholine refers to a generic term for a class of phospholipids that incorporate choline as the head group. They are considered to be the major component of biological membranes and are the most abundant type of phospholipids in the body (1). They are found to have higher concentrations in the liver and brain as compared to other body organs. Natural sources of this supplement include eggs, soybeans, mustard, sunflower, and others.

What are the benefits and mechanism of action (MOA)?

Basically, Phosphatidylcholine can be broken down into choline and sphingomyelin. And as a choline source, this supplement is a direct precursor to the neurotransmitter Acetylcholine. As we all know, Acetylcholine is responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (2). Because Phosphatidylcholine increases the levels of Acetylcholine in the brain, it may result in an enhanced cognition. This includes improved attention span, and faster processing speed. In addition to that, it also improves long term memory storage, learning capacity, fluid intelligence, reasoning and focus. On the other hand, Sphingomyelin refers to a type of sphingolipid found in animal cells that serves to have several functions. This includes having a role in the insulation of nerve fibers as well as signal transduction. It also serves to play an important role for the development and protection of nerve cells (3). It works by building and repairing new cell membranes and maintains the integrity and stability of our neuron’s cell membranes. As a result, Phosphatidylcholine serves to enhance cognitive function and neuroplasticity as well as our brain health and neuronal communication.

Studies have also shown that the benefits of Phosphatidylcholine are not limited to just the Cholinergic system and the cell membranes. It also plays a role in fighting certain diseases particularly that of the liver. It works by avoiding the build-up of fatty acids in the liver, supporting liver repair, and protecting it from all three forms of hepatitis. Moreover, Phosphatidylcholine has been found to reduce inflammation, maintain healthy cholesterol levels, boost immune system and help protect against infections and diseases.

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On the other hand, Phosphatidylcholine also aids in the transportation of lipids throughout the body, helps in membrane mediated cell signalling and the activation of enzymes. Because of this, energy metabolism is enhanced.

What should I consider before taking it?

1. Proper Phosphatidylcholine dosage and frequency

As for any drug or supplement you are taking in, it very important to know the proper dosage, frequency and administration for you to attain the effects that you wanted. So as with Phosphatidylcholine, how much of it does our body really need? Generally, experts recommended a daily Phosphatidylcholine dose of 400 mg. This dose may then be divided and taken into multiple administrations within the day to achieve a more constant and sustained release of effects. A daily dose of up to 5 grams is considered safe to use although a high dosage such as this is not needed.

When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.

2. Can I take Phosphatidylcholine with other supplements and nootropics?

Yes, of course. Taking different nootropics to achieve a common goal or reduce potential side effects is called stacking. Stacking has been a very popular practice nowadays since it does not only potentiate the cognitive and health benefits that you wanted to achieve but also, stacking helps prevent or minimize the potential side effects of a certain supplement. Working alone, Phosphatidylcholine seems to have numerous cognitive and health benefits already. But when stacked with other supplements, the effects of which are synergistic with the other drugs. As a Choline source, it is common to stack Phosphatidylcholine with the Racetams such as Piracetam, Pramiracetam, Phenylpiracetam, and among many others. This is because Racetams stimulate the brain through the Cholinergic system. As a result, in order for it to act efficiently, it needs a steady supply of Acetylcholine. And this quality supply of Choline may be provided by Phosphatidylcholine. In this way, the Phosphatidylcholine-Pramiracetam stack works in both ways by enhancing cognitive function and by synergizing the effects of each other. Moreover when there is insufficient source of Choline, headaches may occur and is one of the most common side effects of the Racetams. With this choline source at hand, you can surely reach your peak cognitive performance while preventing and/or minimizing the occurrence of headaches.

Don’t limit yourself with the usual stacks available today instead you may want to try taking Phosphatidylcholine with other supplements to achieve your desired health benefits. If you wanted to have a more natural stack, you may consider taking Lion’s Mane Mushroom, Ginkgo Biloba and among many others. Now if you wanted to have a more significant boost in your cognitive performance, you may stack it with other potent nootropics such as Noopept. However, we should bear in mind that not all supplements may go well with the others. Because of this, you should have a thorough understanding of each of the supplements you wanted to take together. Or better yet, you may consult your doctor or healthcare provider first.

3. Phosphatidylcholine safety and side effects

The use of Phosphatidylcholine has been considered safe to use and is well-tolerated. However, some Phosphatidylcholine side effects have been reported due to intake of high dosages. When taken by mouth, it may result in diarrhea, excessive sweating, and stomach upset. When administered intravenously, it may cause irritation, swelling, redness, itching, bruising, burning and pain at the injection site. When this supplement has been injected into a fatty growth of lipoma, it may cause an inflammatory reaction that could make the tumor more fibrous. In addition to that, long term use of Phosphatidylcholine is still not known. (4)

It is important to note that Phosphatidylcholine should not be taken by a specific population due to possible drug interactions. It has been known to moderately act with anticholinergics, medications for Alzheimer’s disease or Acetylcholinesterase inhibitors, and other medications used for the treatment of glaucoma. (4)

4. Other Choline sources

It has been found that Phosphatidylcholine has low bioavailability as compared to other choline sources. This is because after ingestion, it is metabolized in the liver first. After which, 60% of the compound is broken down and digested by the bacteria in the gut. As a result, this supplement tends to have a higher dosage to achieve maximal results. Now if you are finding for a more potent choline source that has higher bioavailability, excellent choices, read Alpha GPC benefits and Citicoline benefits.

Where can I buy Phosphatidylcholine?

You can purchase Phosphatidylcholine online. It is available over the counter and does not require a prescription. Buy Phosphatidylcholine now and experience an enhanced mental performance while maintaining a healthier mind and body.

References:
  1. https://en.wikipedia.org/wiki/Phosphatidylcholine
  2. http://www.chemistryexplained.com/A-Ar/Acetylcholine.html
  3. https://en.wikipedia.org/wiki/Sphingomyelin#Function
  4. http://www.webmd.com/vitamins-supplements/ingredientmono-501-phosphatidylcholine.aspx?activeingredientid=501&activeingredientname=phosphatidylcholine
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Results & Experiences

Daily Dosage # Stacks
100.00 mg 1
200.00 mg 1
Commonly Paired With # Stacks
Phosphatidylserine 3
Fish Oil 2
Uridine 2
L-Theanine 1
Vinpocetine 1
Glycine 1

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Wiki Last Updated: 2016-02-15