PRL-8-53 was patented by the late Dr. Nikolaus Hansl, a neuropharmacologist of Creighton University in Nebraska in the year 1975. PRL-8-53 is significantly nootropic and does not cause harm. Animal test studies show that PRL-8-53 has the ability to enhance learning in mice without any negative effects. In a human study conducted last 1978, a single dose of PRL-8-53 was found to improve word retention by greater than 200 percent.
Right after Dr. Nikolaus Hansl patented PRL-8-53, he funded a human study that greatly supports the drug’s benefits as a nootropic. The study has 30 physically fit individuals between the ages 24 and 86 years. The retention capacity of each individual in the study was measured. The results show that those individuals having initially low scores or who were over 30 years of age showed significant improvement after taking a 5 mg dose of PRL-8-53. However, those participants that had high baseline retention scores demonstrated little improvement after taking PRL-8-53. No adverse effects reported in the study.
Durk Pearson furtherly increases the people’s interest in PRL-8-53 by saying that PRL-8-53 functions well in enhancing a person’s memory. Normally, a person can recall at least 7 to 8 digits by looking at them for one second. However, PRL-8-53 amazingly provides an average individual a memory span of 21 to 22 digits.
Despite of all the positive effects that PRL-8-53 bring, and all the evidences that support the nootropic capability and safety of this drug, the testing is limited and this drug is still considered experimental.
The exact mechanism of action of PRL-8-53 is not fully understood, however, it was believed that it could regulate the brain’s response and production of numerous neurotransmitters. Dr. Hansl’s reports on both animal and human studies indicated that PRL-8-53 has the ability to potentiate dopamine, improves the brain’s response to acetylcholine, and partially inhibits the secretion of serotonin. Despite that Dr. Hansl reported those actions in his human study in 1978, it does not precisely describe the mechanism of action.