Methylhexanamine or methylhexamine, commonly known as dimethylamylamine (DMAA) or 1,3-dimethylamylamine (1,3-DMAA) was invented by Eli Lilly and Company in the year 1944. It was a nasal decongestant administered through inhalation having the trade names are Geramine and Forthane. On the year 1983, Methylhexanamine was voluntarily withdrawn from the market.
There are at least five deaths that has been associated with the use of methylhexanamine-containing medications. Methylhexanamine was known to have similar compounds with geraniums, however, further studies are needed in order to prove the safety of Methylhexanamine. Since the year 2006, Methylhexanamine has been exclusively sold as a stimulant or energy-enhancing dietary supplement. Many government agencies and sports authorities banned the use of Methylhexanamine.
Methylhexanamine was introduced and was sold as a nasal decongestant by Eli Lilly and Company under the brand name Forthane on the month of April in the year 1944. On the year 1983, Eli Lilly voluntarily withdrew Methylhexanamine from the market. Pharmaceutical Industries in the 20th century has become interested in compounds in this class as nasal decongestants. This led to Methylhexanamine and 4 other compounds, namely octin, propylhexedrine, tuaminoheptane, and oenethyl to be brought in the market for that use. These compounds were later on approved for its purpose on keeping a sufficiently high blood pressure for patients under anesthesia.
After ephedrine was finally banned in the United States last 2005, Methylhexanamine was once again introduced in the year 2006 by Patrick Arnold as a dietary supplement. Similar to the combination of ephedrine and caffeine, numerous supplements that focused on fat reduction and boosting energy used Methylhexanamine in combination with other substances like caffeine. Proviant Technologies, a name held by Patrick Arnold’s company, introduced Methylhexanamine under the trademarked name Geranamine.
Studies show that Methylhexanamine is found is some types of Geraniums. Some methylhexanamine-containing supplements list “geranium extract” or “geranium oil” as sources of Methylhexanamine. However, Methylhexanamine in these supplements are just added in a form of synthetic material, thus, geranium oils do not truly contain Methylhexanamine.
Supplements containing Methylhexanamine have emerged as pre-workout products. They are known to have thermogenic effects that helps reduce body fat. The stimulation effect of Methylhexanamine can be compared to drinking two to three cups of coffee. Similar to caffeine, Methylhexanamine can also increase norepinephrine levels because of its fat-mobilizing action. Eli Lilly and Company failed to perform experiments of Methylhexanamine on human subjects, however, recent studies tested its effects on humans. Studies that have been conducted nowadays to prove Methylhexanamine’s effectiveness were mostly placebo-controlled, double-blind studies. Though they have used a small number of test subjects, the results of these studies are scientifically acceptable. On the off chance that you would like to explore more about Methylhexanamine, most of these studies are avaiable online.
The Food and Drug Administration (FDA) stated that Methylhexanamine can cause symptoms such as tightening of the chest, shortness of breath, and heart attack because of its ability to narrow the blood vessels. As mentioned earlier, there have been five reported deaths associated with the use of Methylhexanamine-containing dietary supplements.
Studies about Methylhexanamine reported that it could cause a slight increase in systolic blood pressure if it was used for the first time. However, after a few weeks of using it, the effects would wear off. Some users reported that they have experienced a boost of energy after taking Methylhexanamine supplement but their workout performance was unchanged.
One study shows that within two hours of taking Methylhexanamine supplement, the subjects experienced rise in free fatty acids in the blood stream by 68 percent in women, and 92 percent in men, a rise of glycerol by 65 percent in women, and 29 percent in men, and an increase in energy expenditure by 24 percent in women, and 9 percent in men. The subjects also reported to have a drop in appetite by 24% after using this supplement. Women in the study showed reduction in waistline of 2 cm (0.78 in), while men showed a 3.15 cm (1.24 in) loss.
Another study tested the safety of Methylhexanamine supplement found an average increase in heart rate by six beats per minute after taking it. However, there were no effects found on kidney or liver function, as well as changes in blood pressure after eight weeks of administering Methylhexanamine supplement.
Methylhexanamine is likely not safe when taken orally. Since Methylhexanamine has the ability narrow your blood vessels, this can cause increased blood pressure, heart rate, and the chance of having stroke or heart attack. Some clinical studies show that taking Methylhexanamine-containing products in combination with any other ingredients could increase blood pressure and heart rate. Several reports stated that Methylhexanamine could cause dangerous adverse effects such as lactic acidosis, heart attack, or worse, death.
It is important to keep in mind that supplements and natural products are not always safe and could cause some negative effects in your body when used improperly, therefore, dosages can be important. There are several factors to consider about the dosage of Methylhexanamine, such as the person’s age, health, and several other conditions. At this point, there is no available guideline for its appropriate dosage. It is vital that you should consult your physician or pharmacist and follow relevant directions of the product labels in order to be safe.References:
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