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Idebenone

Idebenone Dosage & Review

Idebenone Review Idebenone is a shorter chained quinone compound (compared to that of the longer chained CoQ10) that offers high levels of bioavailabilty and functions to provide anti-aging effects and provide overall brain health. This is a drug that was created by Takeda Pharmaceutical Company as a treatment option for neurodegenerative disorders and cognitive deficits. In rodent studies, administration of Idebenone leads to improved ability to learn and memorize and some have suggested that this substance may offer similar nootropic benefits among humans. Additionally some believe that it may actually provide neuroprotective benefit as well. Idebenone is categorized under Neuroprotective Agents.
Idebenone
Also Known
Description Idebenone is a shorter chained quinone compound (compared to that of the longer chained CoQ10) that offers high levels of bioavailabilty and functions to provide anti-aging effects and provide overall brain health. This is a drug that was created by Takeda Pharmaceutical Company as a treatment option for neurodegenerative disorders and cognitive deficits. In rodent studies, administration of Idebenone leads to improved ability to learn and memorize and some have suggested that this substance may offer similar nootropic benefits among humans. Additionally some believe that it may actually provide neuroprotective benefit as well.
Typical Dose 90-120mg
Stacks
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Benefits and Effectiveness

Idebenone Dosage

90-120mg

Side Effects

Reported side effects related to Idebenone usage include gastrointestinal problems, nausea, anxiety, ansomnia, headaches, loss of appetite, allergic reactions, and possible flu-like symptoms.

Idebenone Review: What is Idebenone?

Idebenone

Idebenone is slowly making its noise today as a powerful anti-aging supplement and longevity booster. Being a synthetic version of coenzyme Q10 or CoQ10, Idebenone has a higher bioavailability thus delivering its results faster and longer lasting. This characteristic may be attributed to its structure being a shorter chained compound. But, how does Idebenone work in our body? And what are its benefits to an individual’s cognition and overall health? Let us now take a closer look at Idebenone and how it acts.


What are the benefits of Idebenone and its mechanism of action?


1. Idebenone for a healthy brain Idebenone has been known to be a powerful supplement that promotes a healthier brain. These may be attributed to a couple of factors. First is due to Idebenone’s antioxidant properties. It actually protects the brain and scavenges toxins and free radicals. Free radicals refer to molecules that are unstable and highly reactive causing damage to cells. Because of this damage, it may lead to a number of diseases such as cancer, cardiovascular diseases, and age-related diseases (1). Antioxidants, like Idebenone, work by neutralizing these free radicals and oxidative stress thus, preventing the destructive processes that the latter may bring. (4)

Another mechanism through which Idebenone promotes a healthy brain is its influence on the hormone NGF or Nerve Growth Factor. NGF works both as a promoter of a healthy brain as well as a cognitive enhancer. Basically, Nerve Growth Factor is responsible for the growth, maintenance, proliferation, and survival of certain neurons. Moreover, it serves to have influence also on the survival of the pancreatic beta cells and the regulation of the body’s immune system (2). With Idebenone having a positive influence on NGF, there would be an enhanced cognition. This may be attributed to the growth and maintenance of the health of our neurons. If our neurons are functioning efficiently, then the relay of the impulses from one neuron to another would be excellent. Moreover, Idebenone encourages growth and branching of axons. These axons, which are also called nerve fibers, are responsible for the conduction of electrical impulses away from our body. An example of which are the impulses directed for the proper functioning of our organs and muscles. With the abundance of axons, better transmission of impulses is achieved and there will be an overall enhanced cognition.

Because of these mechanisms that Idebenone possesses, it will promote a healthier body and brain, protecting and preventing us from accumulating diseases in the future. As a result, our cognitive and physical performance will be enhanced and be more efficient.

2. Idebenone for cognition

Idebenone also serves to improve a person’s cognition through 2 ways. First is its influence on the Cholinergic system. Idebenone actually increases the levels of Acetylcholine in the brain and as we all know, Acetylcholine is the neurotransmitter responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (3). Because Idebenone increases the levels of Acetylcholine the result will be an enhanced cognition. This includes increased learning ability, enhanced memory formation, storage and recall, improved attention span and focus, and faster processing speed.

On the other hand, researches have claimed that Idebenone acts to improve the communication between the two hemispheres of the brain and can improve one’s problem solving skills and creative thinking. This type of communication is then referred to as transcallosal communication.

In the medical field, a study that was published by the National Institutes of Health shows that Idebenone helps slow the progression of Alzheimer’s disease.

3. Idebenone for mood and sleep

Aside from the cognitive and neuroprotective properties of Idebenone, it also serves to have benefits with one’s mood and sleep. This may be attributed to an increase in Dopamine levels thus, improving one’s mood, attention and focus. Also, there would be an increase in Serotonin levels which in turn, enhances a person’s quality of sleep as well as the restoration of proper sleeping patters.


How do I maximize the effects of Idebenone?


1. Proper Idebenone dosage and frequency

It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Idebenone, how much of it do we really need each day? There has been a wide range of suggested doses ranging from 75 mg to 1000 mg daily. However, some Idebenone reviews suggest that a dose of 500 mg daily is proven to be effective in producing its benefits. The daily dose may be divided and taken into multiple administrations if you wanted a more constant and sustained release of effects. On the other hand, higher dosages of Idebenone may cause difficulty falling asleep especially when taken later during the day. So, it would be best to take Idebenone in the morning and not later than midday.

When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. Just like Idebenone, you might want to start with a daily dose of 100 mg to 200 mg and increase it gradually over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.

2. Stacking Idebenone

Stacking has been a popular practice nowadays. This is done for the purpose of maximizing a drug’s potential and also, in order to yield more positive effects, to synergize each other, or to eliminate or minimize the side effects that the drugs may provide. With the case of Idebenone, what drugs and supplements are best to use in conjunction to it? It is common that Idebenone be stacked with a good quality source of choline such as Alpha GPC, Citicoline, and among many others. Idebenone and Centrophenoxine (no link available at the site) stack is one of the most common combination to promote longevity and for advanced anti-aging protection..

Having a thorough understanding of the drugs you wanted to have in a stack is important because some drugs might not go well with the others. Stacking supplements greatly depends on your needs and personal preferences however, it would be best to consult your doctor or healthcare provider first.


Idebenone Safety and Side Effects


Idebenone is generally considered safe to use and is well-tolerated. At the present time, there has been no other side effects reported yet except for difficulty falling asleep when Idebenone is taken at higher dosages or later during the day.


Where can I buy Idebenone?


You can purchase Idebenone online. Drug is available over the counter and thus, does not require prescription from a doctor. It is readily available in Idebenone capsule, tablet or powder form. If you wanted an easier administration, you may opt to take the capsule and tablet form. However if you wanted to save more from your money, you may Idebenone powder in bulk. Either way, all three forms still deliver the same benefits. Buy Idebenone now and experience a variety of its health benefits.


References:
  1. http://www.thefreedictionary.com/free+radical
  2. https://en.wikipedia.org/wiki/Nerve_growth_factor#Neuronal_proliferation
  3. http://www.chemistryexplained.com/A-Ar/Acetylcholine.html
  4. Mordente A, Martorana GE, Minotti G, Giardina B. Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone). Chem Res Toxicol. 1998
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Results & Experiences

Daily Dosage # Stacks
100.00 mg 5
150.00 mg 1
Commonly Paired With # Stacks
Fish Oil 5
Inositol 5
Galantamine 4
Alpha GPC 4
Lions Mane 4
Piperine 4

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Wiki Last Updated: 2016-02-15