Hydrafinil, also known as 9-Fluorenol, is under the eugeroic class of drugs or the wakefulness promoting drugs. It is a metabolite of Modafinil but is believed to be 39% more effective although their mechanism of actions are not the same. However in contrast with Modafiinil, Hydrafinil has a shorter half life having only 6 to 8 hours. According to studies, Hydrafinil has also been shown to enhance short-term visual memory, as well as improving attention and information processing. Also, it may decrease impulsitivity and increase your logical thinking.1
Hydrafinil is categorized under Eugeroics.
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DescriptionHydrafinil, also known as 9-Fluorenol, is under the eugeroic class of drugs or the wakefulness promoting drugs. It is a metabolite of Modafinil but is believed to be 39% more effective although their mechanism of actions are not the same. However in contrast with Modafiinil, Hydrafinil has a shorter half life having only 6 to 8 hours. According to studies, Hydrafinil has also been shown to enhance short-term visual memory, as well as improving attention and information processing. Also, it may decrease impulsitivity and increase your logical thinking.1
Reports have shown that Hydrafinil have fewer and milder side effects compared to Modafinil. However, it may still include headache, nausea, nervousness, dizziness, anxiety, and difficulty sleeping.
Hydrafinil Review: What is Hydrafinil?
Hydrafinil, also known as Fluorenol, is an unregulated examination synthetic initially synthesized by Cephalon Pharmaceuticals as an eugeroic (attentiveness advancing agent). After its synthesis, fluorenol was one of the few agents to be considered as a theoretical successor to the advanced and FDA-approved drug, Provigil (Modafinil). Studies on animals demonstrated that fluorenol displayed approximately 39% more noteworthy eugeroic viability than modafinil over a short-term span.
Be that as it may, for undisclosed reasons, Cephalon scrapped advancement of fluorenol as a possibly novel eugeroic. Rather, they guided endeavors and assets to examine, create, and showcase the medication armodafinil. Armodafinil, which is sold under the brand name "Nuvigil" would get to be known as the official pharmaceutical successor to Provigil, leaving numerous to ponder whether fluorenol may have been a predominant advancement.
Some hypothesize fluorenol's previous utilization as a bug spray in the late 1930s, demonstrated lethality to aquatic life, and a lapsing Cephalon patent may have been the cause to suspend its development. Starting 2015, fluorenol has recaptured prevalence among nootropic fans and is presently being sold as an unregulated substance online under the brand name "Hydrafinil."
Numerous self-experimenters are vouching for its viability, however, others are suspicious of these cases and are careful about its undocumented, conceivably dangerous symptom profile.
Mechanism of Action
Experts claim that Hydrafinil functions as a negligible dopamine reuptake inhibitor (DRI) and a 5-HT6 receptor antagonist. However, the true mechanism of action of Hydrafinil is not clear. Whether these speculations are true or not, it has not been experimented in humans. In relation to that, hydrafinil enhances cognitive performance via upregulation of noradrenergic and dopaminergic transmission.
Dopamine reuptake inhibitor: Increase in dopamine production is known to improve cognition. Hydrafinil plays a role as a dopamine reuptake inhibitor, thus, increasing dopamine concentrations.
5-HT6 antagonist: Antagonism of 5-HT6 receptor can result to increase in norepinephrine and dopamine concentrations in the prefrontal cortex, as well as increasing the production choline and glutamate in different parts of the brain. Makers of Hydrafinil theorize that it functions as a 5-HT6 receptor antagonist.
Increase Glutamate levels: As mentioned earlier, antagonism of 5-HT6 receptors increases the production of glutamate in the brain. This could lead to enhanced memory and learning process. There is a great possibility that Hydrafinil’s function as a 5-HT6 receptor antagonist could result to improvement in cognitive performance.
Increase Norepinephrine levels: Manufacturers of Hydrafinil claim that it increases norepinephrine levels specifically in the prefrontal cortex by antagonizing 5-HT6 receptor. Increase in concentrations of norepinephrine could result to improvement of cognition. However, there’s no enough evidence to prove this theory.
Increase Histamine levels: Hydrafinil is known to enhance histamine levels in the hypothalamus. Histamine plays an important role in normalizing our circadian rhythm and regulating sleep-wake cycles.
What advantages does it have?
At the point when contrasted with different eugeroics, hydrafinil may have some advantages. Since it hasn't been all around examined in people, whether the speculative points of interest are precise stays obscure. Some of the potential favorable advantages include: inexpensive, lessened incitement, predominant eugeroic viability, and its unregulated status.
Inexpensive: Hydrafinil is sold at around $25 for two grams by some vendors, some sell it at a much lower price. It would only cost you around $1.25 per dose if you will buy it at this price, and administered 100 mg. This cost much lesser than purchasing modafinil from online drug markets.
Mood booster: Numerous individuals believe that hydrafinil may enhance their state of mind to a more prominent degree than modafinil. Numerous people have had achieve utilizing modafinil for depression and/or as an anti-depressant. Since hydrafinil might be more serotonergic than different eugeroics, its ability to enhance state of mind might be much better than related substances.
Less stimulating: Not everybody needs the same level of stimulation that can be achieved from use of armodafinil or modafinil. Recounted reports and producers theorize that hydrafinil is likely less empowering than different eugeroics. This implies it might be more less likely to cause tension, jitters, and/or an accident. Furthermore, despite the fact that modafinil isn't viewed as addictive, hydrafinil might be less addictive as a result of decreased psycho-stimulation.
Subtler impact: The general impact of hydrafinil is thought to be subtler and "cleaner" than different eugeroics. Whether it is less subtle is easily proven wrong, yet numerous recounted reports make this declaration. Some may not need as noticeable of an impact as gotten from modafinil, and may wish to take something less strong.
Unregulated: The way that hydrafinil is unregulated might be seen as an advantage in that it is accessible to anybody that needs it. As such, those individuals who wish to explore different avenues regarding it aren't kept down by the government. Subsequently, hydrafinil can be bought by anybody and can be utilized under their own discretion.
Increase attentiveness: Hydrafinil's capacity to increase attentiveness might be predominant than different eugeroics like modafinil. In spite of the fact that it might be less stimulating, it might really maintain alertness for a more extended time and/or in a larger number of clients than modafinil.
In any case, it is always good to start at the smallest dose then gradually increase it once you have become familiar with its effects. The usual dose of Hydrafinil is 50 mg, taken 1 to 3 times a day as needed.
What disadvantages does Hydrafinil have?
Contrasted with different eugeroics, there are some undeniable potential disadvantages connected with hydrafinil. Maybe the greatest disadvantage is that we don't really know whether it is safe, connected with unfavorable impacts, and/or harmful long term impacts. Anybody planning to use hydrafinil ought to be aware of all its possible disadvantages.
Ineffective: It may be the case that hydrafinil is totally useless in people as an eugeroic as well as for different purposes. There is no clinical information to propose its viability in people and restricted information to recommend its adequacy in animal models. At first glance, one may conclude that since it is like modafinil, that it is naturally "effective" for a particular reason. It might wind up being entirely ineffective.
Less stimulating: A few clients may dislike the way that hydrafinil is less stimulating than other substances like armodafinil and modafinil. In case you are searching for higher-octane eugeroics stimulation, hydrafinil might not be good choice. Numerous people are looking for something that increases excitement to a huge degree as alertness.
Unregulated: In spite of the fact that numerous see "unregulated" substances as positive in that there's no compelling reason to consult a physician and/or pay high expenses for a medicine, this unregulated status is likewise dangerous. It's risky in that anybody can purchase hydrafinil on the web, utilize it (at whatever dose they please), and they don't generally have an idea about the contraindications and/or what actions it does to their brain and body.