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Conjugated Linoleic Acid

Conjugated Linoleic Acid Dosage & Review

Conjugated Linoleic Acid Review A slightly altered form of the essential fatty acid linoleic acid. Conjugated Linoleic Acid is categorized under Fatty Acids. It is also known as CLA, Acide Linoléique Conjugué, Acide Linoléique Conjugué Cis-9, trans-11, Acide Linoléique Conjugué trans-10, cis-12, Cis-9, trans-11 Conjugated Linoleic Acid, Cis-Linoleic Acid, CLA, CLA-Free Fatty Acid.
Conjugated Linoleic Acid
Also Known CLA, Acide Linoléique Conjugué, Acide Linoléique Conjugué Cis-9, trans-11, Acide Linoléique Conjugué trans-10, cis-12, Cis-9, trans-11 Conjugated Linoleic Acid, Cis-Linoleic Acid, CLA, CLA-Free Fatty Acid
Description A slightly altered form of the essential fatty acid linoleic acid.
Typical Dose 6,400mg
Stacks
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Benefits and Effectiveness

  • Adiponectin - Neutral [1]
  • Blood Glucose - Neutral [2]
  • Blood Pressure - Neutral [3]
  • C-Reactive Protein - Neutral [4]
  • Fat Mass - Neutral [5]
  • HbA1c - Neutral [6]
  • IGF-1 (aka Insulin-like growth factor-1) - Neutral [7]
  • Inflammation - Neutral [8]
  • Insulin Sensitivity - Neutral [9]
  • LDL-C - Neutral [10]
  • Lean Mass - Increased [11]
  • Leptin - Neutral [12]
  • Liver Enzymes - Neutral [13]
  • Metabolic Rate - Neutral [14]
  • TNF-Alpha (aka TNF-α - Neutral [15]
  • Triglycerides - Increased [16]

Conjugated Linoleic Acid Dosage

6,400mg

Side Effects

Large doses of CLA can cause side effects such as diarrhea, nausea, stomach pains and gas.

Conjugated Linoleic Acid Review: What is Conjugated Linoleic Acid?

CLA is derived from the Greek word “linon” or flax while oleic means “of, or relating to.” It is one of the main fatty acids essential in the diet alongside omega-3 or alpha-linoleic acid. Since it is categorized as an essential compound, it means that the human body cannot synthesize it from other food components. Also known as omega-6 fatty acid, Linoleic acid is a polyunsaturated fatty acid that plays a role in the biosynthesis of prostaglandins and cell membranes. It also functions to keep the skin permeable to water through specific metabolism. Moreover, Linoleic acid is found in large amounts in vegetable oils (1)(2)(3). If a person does not acquire the sufficient amounts of linoleic acid, he or she may suffer some symptoms such as dry hair, hair loss, and poor wound healing.

Now, what is Conjugated Linoleic Acid and how does it differ from Linoleic Acid? Basically, Conjugated Linoleic Acid’s name comes from the arrangement of the double bonds in the fatty acid molecule. These are conjugated and separated by a single bond between them. CLA, or Conjugated Linoleic Acid, is technically a natural type of trans-fat and can either be cis- or trans- double bonds. (6)

Since Conjugated Linoleic Acid is a natural compound, what are the foods that have the highest content with it? It has been found that Kangaroo meat has the highest concentration of CLA. Foods from grass-fed ruminants such as the cows, goats, and sheeps also have very high levels of Conjugated Linoleic Acid in them. In addition to that, it has been found that the CLA content is about 300-500% higher in beef and dairy products from grass-fed cows than the grain-fed cows. Other food sources rich in CLA include dairy products, beef, eggs, and mushrooms. (1)(5)(6)


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What are the benefits of taking Conjugated Linoleic Acid?

At the present time, CLA is widely known and marketed as a dietary supplement for its anti-cancer benefit and as a body building aid. But what can we get more from taking this supplement?

An important benefit in which CLA is known for is its effect on our body’s immune system. This enhancement is particularly effective in the prevention of different types of cancer. CLA has been used in the medical setting to reduce the risk of having cancer such as that of colon cancer, rectal cancer, and breast cancer. It is believed that its mechanism of action is through blocking the growth and spread of malignant tumors particularly those influencing cell replication and the mechanisms of carcinogenesis. Moreover, it has been used for atherosclerosis as well. CLA can also benefit those individuals suffering from Diabetes since the supplement can replace the effect of the artificial diabetic drugs. Also, several studies have shown that CLA serves to increase mineralized bone formation. (5) (6)

CLA is also one of the most studied supplements for its potential effect in weight loss. After its discovery in 1987 for its anti-cancer properties, it was later on discovered to reduce body fat levels as well. Researchers have shown that the supplement works through several anti-obesity mechanisms. This includes reducing the caloric intake from food, increase the fat burning process without destroying muscle mass, stimulating the breakdown of fats, and inhibiting the production of fats. In addition to that, the American Journal of Clinical Nutrition has shown that subjects who have taken 3.2 grams of CLA per day had dropped fat mass of about 0.2 lbs per week. The supplement has also shown to improve an individual’s body composition. (5)

Because of CLA’s action towards the body’s metabolism, its use has been popular to the athletic and fitness world. Among athletes, body builders, and other active individuals, they consider CLA to be

Buy Conjugated Linoleic Acid

An important benefit in which CLA is known for is its effect on our body’s immune system. This enhancement is particularly effective in the prevention of different types of cancer. CLA has been used in the medical setting to reduce the risk of having cancer such as that of colon cancer, rectal cancer, and breast cancer. It is believed that its mechanism of action is through blocking the growth and spread of malignant tumors particularly those influencing cell replication and the mechanisms of carcinogenesis. Moreover, it has been used for atherosclerosis as well. CLA can also benefit those individuals suffering from Diabetes since the supplement can replace the effect of the artificial diabetic drugs. Also, several studies have shown that CLA serves to increase mineralized bone formation. (5) (6)

CLA is also one of the most studied supplements for its potential effect in weight loss. After its discovery in 1987 for its anti-cancer properties, it was later on discovered to reduce body fat levels as well. Researchers have shown that the supplement works through several anti-obesity mechanisms. This includes reducing the caloric intake from food, increase the fat burning process without destroying muscle mass, stimulating the breakdown of fats, and inhibiting the production of fats. In addition to that, the American Journal of Clinical Nutrition has shown that subjects who have taken 3.2 grams of CLA per day had dropped fat mass of about 0.2 lbs per week. The supplement has also shown to improve an individual’s body composition. (5)

Because of CLA’s action towards the body’s metabolism, its use has been popular to the athletic and fitness world. Among athletes, body builders, and other active individuals, they consider CLA to be an important component in their workout stack. With this supplement, it promotes fat loss and helps them build lean body mass and can then result in an improved physical performance.

What should I consider before taking Conjugated Linoleic Acid?

It is very crucial for any drug or supplement to be taken at the right amount and frequency for it to produce the desired effects while possibly eliminating or minimizing the undesired ones. With the case of Conjugated Linoleic Acid, how much of it do we really need each day? Generally, the recommended dosage of CLA is between 1.8 grams to 7 grams. This daily dose may then be divided and taken into multiple administrations within the day if you wanted to have a more sustained release of benefits. This dose has also been used for reducing body fat among obese patients. (4)

When starting with any new drug or supplement, it would be best to start off with the lowest possible dose to see how you respond and then gradually increasing it over time. You might also want to consider consulting your doctor or healthcare provider first since a person’s condition and health status may play a role.

In 2008, Conjugated Linoleic Acid was classified as generally recognized as safe (GRAS) by the United States Food and Drug Administration. Although this supplement is well-tolerated, some people may respond differently to CLA and may cause some mild side effects. This includes stomach upset, diarrhea, nausea and fatigue. It can also cause an increased rate of oxidative stress due to an accelerated metabolism. When taken at doses beyond the recommended, CLA may cause an increased accumulation of fat in the liver which predisposes an individual of having metabolic syndrome and diabetes. It can drive the natural inflammation process, can cause insulin resistance, and can lower HDL levels or the good cholesterol. Possible health consequences are still yet to be discovered when it comes to prolonged treatment periods. (1) (6)

On the other hand, it is important to note that Conjugated Linoleic Acid may be contraindicated or used with caution among some individuals. This includes people suffering from bleeding disorders since it might slow down the blood clotting process even more. With this, there will be an increased risk of bruising and bleeding disorders. Also, people suffering from metabolic syndrome are contraindicated to use CLA since it may increase the risk of having diabetes. Conversely, people who already have diabetes may experience worsening of symptoms with the use of CLA. For individuals who will be having a surgery, CLA should be stopped at least 2 weeks before the operation day. This is because the supplement can cause extra bleeding during and after the operation. (4)

There has been no enough evidence that CLA is safe to use among children, pregnant and lactating mothers. So, it would be best to avoid its use in this specific population.

Where can I buy Conjugated Linoleic Acid?

You can purchase CLA online. Drug is available over the counter and thus, does not require prescription from a doctor. Buy Conjugated Linoleic Acid now and experience a significant boost in your immune system as well as its other health benefits.

References:
  1. http://www.news-medical.net/health/What-is-Linoleic-Acid.aspx
  2. https://en.wikipedia.org/wiki/Linoleic_acid#Uses
  3. http://pubchem.ncbi.nlm.nih.gov/compound/linoleic_acid#section=Top
  4. https://en.wikipedia.org/wiki/Conjugated_linoleic_acid
  5. http://www.webmd.com/vitamins-supplements/ingredientmono-826-conjugated%20linoleic%20acid.aspx?activeingredientid=826&activeingredientname=conjugated%20linoleic%20acid
  6. http://supplementpolice.com/conjugated-linoleic-acid-cla/
  7. http://authoritynutrition.com/conjugated-linoleic-acid/
Reviewer: Kathleen R. RN, PT
Wiki Last Updated: 2016-02-12
BUY CONJUGATED LINOLEIC ACID NOW
^1 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^1 http://www.ncbi.nlm.nih.gov/pubmed/18356842
^1 http://www.ncbi.nlm.nih.gov/pubmed/17031391
^2 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^2 http://www.ncbi.nlm.nih.gov/pubmed/20200257
^2 http://www.ncbi.nlm.nih.gov/pubmed/18287358
^2 http://www.ncbi.nlm.nih.gov/pubmed/17298695
^3 http://www.ncbi.nlm.nih.gov/pubmed/21697535
^3 http://www.ncbi.nlm.nih.gov/pubmed/21270839
^3 http://www.ncbi.nlm.nih.gov/pubmed/17531459
^3 http://www.ncbi.nlm.nih.gov/pubmed/16549463
^4 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^4 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^4 http://www.ncbi.nlm.nih.gov/pubmed/20679151
^4 http://www.ncbi.nlm.nih.gov/pubmed/19923377
^5 http://www.ncbi.nlm.nih.gov/pubmed/22261578
^5 http://www.ncbi.nlm.nih.gov/pubmed/11110851
^5 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^5 http://www.ncbi.nlm.nih.gov/pubmed/20679151
^6 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^6 http://www.ncbi.nlm.nih.gov/pubmed/17531459
^6 http://www.ncbi.nlm.nih.gov/pubmed/17031391
^7 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^7 http://www.ncbi.nlm.nih.gov/pubmed/20200257
^7 http://www.ncbi.nlm.nih.gov/pubmed/17510671
^7 http://www.ncbi.nlm.nih.gov/pubmed/17381964
^8 http://www.ncbi.nlm.nih.gov/pubmed/21753062
^8 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^8 http://www.ncbi.nlm.nih.gov/pubmed/16600923
^8 http://www.ncbi.nlm.nih.gov/pubmed/15447895
^9 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^9 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^9 http://www.ncbi.nlm.nih.gov/pubmed/18287358
^9 http://www.ncbi.nlm.nih.gov/pubmed/17623486
^10 http://www.ncbi.nlm.nih.gov/pubmed/22293214
^10 http://www.ncbi.nlm.nih.gov/pubmed/21295383
^10 http://www.ncbi.nlm.nih.gov/pubmed/20679151
^10 http://www.ncbi.nlm.nih.gov/pubmed/20200257
^11 http://www.ncbi.nlm.nih.gov/pubmed/22261578
^11 http://www.ncbi.nlm.nih.gov/pubmed/11110851
^11 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^11 http://www.ncbi.nlm.nih.gov/pubmed/19535429
^12 http://www.ncbi.nlm.nih.gov/pubmed/17298695
^12 http://www.ncbi.nlm.nih.gov/pubmed/17031391
^13 http://www.ncbi.nlm.nih.gov/pubmed/22293214
^13 http://www.ncbi.nlm.nih.gov/pubmed/20679151
^13 http://www.ncbi.nlm.nih.gov/pubmed/19932729
^13 http://www.ncbi.nlm.nih.gov/pubmed/17898458
^14 http://www.ncbi.nlm.nih.gov/pubmed/17823448
^14 http://www.ncbi.nlm.nih.gov/pubmed/17298695
^14 http://www.ncbi.nlm.nih.gov/pubmed/17381964
^14 http://www.ncbi.nlm.nih.gov/pubmed/16924272
^15 http://www.ncbi.nlm.nih.gov/pubmed/21593349
^15 http://www.ncbi.nlm.nih.gov/pubmed/20679151
^15 http://www.ncbi.nlm.nih.gov/pubmed/16277783
^15 http://www.ncbi.nlm.nih.gov/pubmed/22521469
^16 http://www.ncbi.nlm.nih.gov/pubmed/22293214
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^16 http://www.ncbi.nlm.nih.gov/pubmed/18641189
^16 http://www.ncbi.nlm.nih.gov/pubmed/18287358

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Comparisons [ top]


Results & Experiences

Daily Dosage # Stacks
1000.00 mg 4
2.00 pill(s) 3
4000.00 mg 2
500.00 mg 1
2000.00 mg 1
3000.00 mg 1
1.00 pill(s) 1
2400.00 mg 1
3.20 g 1
1.00 tbsp 1
Duration # Stacks
67 days 1
Purpose # Stacks Effectiveness
Fatigue 2
Unknown
Can't tell
None
Slight
Moderate
Major
Weight loss 1
Unknown
Can't tell
None
Slight
Moderate
Major
Lipodystrophy (lipoatrophy or loss of fatty tissue) 1
Unknown
Can't tell
None
Slight
Moderate
Major
Side Effects # Stacks
Fatigue 2
Commonly Paired With # Stacks
Magnesium 11
Vitamin D 11
Green Tea 11
Creatine 11
Fish Oil 9
Vitamin C 9

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