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Agmatine

Agmatine Dosage & Review

Agmatine Review This is a natural compound that was discovered in the early 1900s when scientists decarboxylated the amino acid arginine meaning to say, the carboxylic acid group was removed from Arginine. From a nootropic perspective, agmatine is known to aid in neurotransmission within the brain. It accomplishes this by influencing ion channels, membrane transportation, modulation of nitric oxide, and metabolic processing of polyamine. It is able to cross the blood-brain barrier and functions to improve mood and reduce anxiety. It is also known to influence the Alpha-2 receptor in the adrenergic system and can inhibit some NMDA receptors. Agmatine is categorized under Nutrients. It is also known as Agmatine sulfate, Clonidine-displacing substance, 4-aminobutylguanidine, Decarboxylated arginine.
Agmatine
Also Known Agmatine sulfate, Clonidine-displacing substance, 4-aminobutylguanidine, Decarboxylated arginine
Description This is a natural compound that was discovered in the early 1900s when scientists decarboxylated the amino acid arginine meaning to say, the carboxylic acid group was removed from Arginine. From a nootropic perspective, agmatine is known to aid in neurotransmission within the brain. It accomplishes this by influencing ion channels, membrane transportation, modulation of nitric oxide, and metabolic processing of polyamine. It is able to cross the blood-brain barrier and functions to improve mood and reduce anxiety. It is also known to influence the Alpha-2 receptor in the adrenergic system and can inhibit some NMDA receptors.
Typical Dose 1300-2670mg
Stacks
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Benefits and Effectiveness

  • Pain - Decrease [1]

Agmatine Dosage

1300-2670mg

Side Effects



Agmatine Review: What is Agmatine?

What is Agmatine Sulfate and what is it for?

Agmatine Sulfate or Abmatine is a compound that is naturally produced by our body through a process called decarboxylation in which the chemical called L-Arginine is transformed into Agmatine Sulfate. Agmatine Sulfate is then stored within the neurons inside the brain and is release once these neurons were activated. In the year 1994, Agmatine Sulfate first garnered attention because of studies that were performed to figure out the pharmacological and physiological effects of Agmatine Sulfate. It was discovered that Agmatine Sulfate provides numerous therapeutic benefits which includes blood pressure control, gut health, and pain relief.

Albrecht Kossel was the first one to discover Agmatine in the year 1910. Agmatine is also known as (4-aminobutyl)guanidine. Agmatine was found to have the ability to exert modulatory action at different molecular targets, such as nitric oxide (NO) synthesis, neurotransmitter systems, ion channels, and polyamine metabolism. This serves as bases for future researches about its potential applications.

Because of its storage mechanism and interesting process, Agmatine Sulfate has activities and actions that are quite different as compared to its predecessor. Studies show that Agmatine Sulfate also provides promising effects in terms of stroke protection, neuropathic pain, drug addiction, as well as general cognitive function. Additionally, this compound was considered to be a neuromodulator or a novel neurotransmitter.

What are the effects of Agmatine Sulfate?

The primary mechanism of action of Agmatine Sulfate is to enter the central nervous system by crossing the blood-brain barrier. Once it gets inside the brain, it binds to NMDA Glutamate receptors. Because it was known to be the primary neurotransmitter involved in memory function and synaptic plasticity, it is also responsible for the numerous cognitive effects that this supplement provide.

Research studies claim that Agmatine Sulfate also contains some analgesic effects. It was found to have the ability to improve the effects of both fentanyl and morphine, thus decreasing the intensity of pain, lowering addiction, and increasing tolerance. Some studies show that Agmatine Sulfate works in synergy with marijuana. By releasing numerous amounts of endorphin and opioid chemicals, this compound seems to have synergistic effects on some of these chemicals. Agmatine Sulfate likewise blocks or inhibits the calcium channels and appears to help in regulating Nitric Oxide levels. This is especially true in situations where there is an abnormal high amount of nitric oxide.

What are the benefits of this supplement?

Agmatine Sulfate was known to have numerous benefits. As a matter of fact, it has similar actions with Arginine; however, Agmatine Sulfate appears to have a higher level of potency. It was considered to have a Nootropic effect and could benefit people by improving their mental capacity, and enhancing their athletic performance both in and out of the gym. It may also stack very well with other Nootropic drugs such as Ampakines and Aniracetam. Additionally, Agmatine supplements are known to have anti-anxiety properties, and promote a healthy state of mind.

Numerous individuals use high amounts of Unifram, Sunifram, Modafinil, or other similar nootropic supplements in order to promote excitation of the brain. Agmatine Sulfate also functions as an anti-oxidant since it helps to decrease the activity of Glutamate and inhibits the over excitation of the brain. Some people take Agmatine Sulfate to prevent excitotoxicity caused by some nootropic drugs. Removal of toxins, free radiclas, and other poisonous substances can help promote healthy functions not only to the brain itself but also to the entire human body.

Agmatine Sulfate also provides a number of athletic benefits. This includes improving and enhancing the body’s response to insulin. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. Because of its ability to regulate the levels of nitric oxide in the body, Agmatine Sulfate could also lead to better muscle “pumps” in weight lifters and weight training athletes. In addition, this supplement is thought to stimulate the release of both Leutenizing hormones (LH) and Growth hormones (GH) which are hormones that play a role in enhancing overall body built.

One of the most astounding things about Agmatine Sulfate is it seems to function as an analgesic. This can be beneficial for pain relief. Research studies show that Agmatine Sulfate can be used in combination with cannabis sativa (marijuana) and morphine. It was also found to release numerous types of natural opioid substances and endorphins in the brain. Some experts claim that Agmatine Sulfate could also be beneficial in treating addictions.

What is the recommended dosage for Agmatine Sulfate?

In general, the accepted daily dose for Agmatine Sulfate is somewhere between 250 mg and 2.5 grams. On the other hand, it is recommended that you should take this supplement with caution and avoid taking very high doses. In order to achieve the most fulfilling effects, take this supplement at least 30 to 45 minutes before you start working out. On the off chance that you would want to use this supplement to enhance your brain function, or as an analgesic, it is recommended that you divide it into smaller doses and take it throughout the day.

Is it safe? What are the side effects of this supplement?

According to some research studies, Agmatine Sulfate does not appear to cause any side effects to the user even if taken at very high doses. There are only few studies that were conducted so far, and all of them did not report any side effects associated with the use of Agmatine Sulfate. However, it is not wise to jump into conclusions and decide to take too much of it. As a matter of fact, the amount of dosage that you take will highly depend on your purpose of taking it.

Individuals who are experiencing some pain issues are advised to take higher doses of this supplement. Those individuals who are athletes and decide to use this supplement to enhance their body built are also advised to take high doses. However, for the sole purpose of using it because of its nootropic effects, the recommended dose should be in the middle, around 500 mg to 750 mg per day.

References:
  1. http://www.mrsupplement.com.au/agmatine
  2. https://en.wikipedia.org/wiki/Agmatine
  3. https://examine.com/supplements/agmatine/
  4. https://content.tigerfitness.com/guide-agmatine-sulfate-supplements/
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^1 http://www.ncbi.nlm.nih.gov/pubmed/20447305

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Comparisons [ top]


Results & Experiences

Daily Dosage # Stacks
250.00 mg 2
1300.00 mg 1
1400.00 mg 1
2000.00 mg 1
1500.00 mg 1
1000.00 mg 1
500.00 mg 1
Purpose # Stacks Effectiveness
Depressed mood 1
Unknown
Can't tell
None
Slight
Moderate
Major
Commonly Paired With # Stacks
AcetyLcarnitine 5
Fish Oil 5
Alpha GPC 4
Creatine 4
Magnesium 4
Ashwagandha 4

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Wiki Last Updated: 2016-02-14