Agmatine Sulfate or Abmatine is a compound that is naturally produced by our body through a process called decarboxylation in which the chemical called L-Arginine is transformed into Agmatine Sulfate. Agmatine Sulfate is then stored within the neurons inside the brain and is release once these neurons were activated. In the year 1994, Agmatine Sulfate first garnered attention because of studies that were performed to figure out the pharmacological and physiological effects of Agmatine Sulfate. It was discovered that Agmatine Sulfate provides numerous therapeutic benefits which includes blood pressure control, gut health, and pain relief.
Albrecht Kossel was the first one to discover Agmatine in the year 1910. Agmatine is also known as (4-aminobutyl)guanidine. Agmatine was found to have the ability to exert modulatory action at different molecular targets, such as nitric oxide (NO) synthesis, neurotransmitter systems, ion channels, and polyamine metabolism. This serves as bases for future researches about its potential applications.
Because of its storage mechanism and interesting process, Agmatine Sulfate has activities and actions that are quite different as compared to its predecessor. Studies show that Agmatine Sulfate also provides promising effects in terms of stroke protection, neuropathic pain, drug addiction, as well as general cognitive function. Additionally, this compound was considered to be a neuromodulator or a novel neurotransmitter.
The primary mechanism of action of Agmatine Sulfate is to enter the central nervous system by crossing the blood-brain barrier. Once it gets inside the brain, it binds to NMDA Glutamate receptors. Because it was known to be the primary neurotransmitter involved in memory function and synaptic plasticity, it is also responsible for the numerous cognitive effects that this supplement provide.