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Cognitive Enhancement 452 Updated: 2016-11-27 Jean-PhilippeC
detailed stack for improving Mitochondria/BDNF/NGF!

290 Potential Effects from this Stack

Effect OnScaleContributors
Cognition8 Green Tea Catechins, Pycnogenol, Zinc, Noopept, Phosphatidylserine, AcetylCarnitine, Resveratrol, Tyrosine, Alpha GPC
Insulin Sensitivity8 Green Tea Catechins, Inositol, Vitamin E, Vitamin D, Zinc, Fish Oil, Magnesium, Creatine, AcetylCarnitine, Melatonin, Resveratrol
Free Testosterone4 Green Tea Catechins, Vitamin E, Vitamin D, Shilajit, Zinc, Phosphatidylserine, Fish Oil, Magnesium, Creatine, AcetylCarnitine
Memory4 Vitamin E, Noopept, Phosphatidylserine, Fish Oil, Creatine, Melatonin
Attention3 Pycnogenol, Phosphatidylserine, Fish Oil, Creatine, AcetylCarnitine, Melatonin
Lean Mass3 Vitamin D, Fish Oil, Creatine, AcetylCarnitine
Blood Flow3 Green Tea Catechins, Pycnogenol, Vitamin E, Fish Oil
Growth Hormone3 Creatine, Melatonin, Alpha GPC
Sleep Quality3 Valeriana officinalis, Pyrroloquinoline quinone, Magnesium, Melatonin, Lions Mane
Anaerobic Exercise2 Phosphatidylserine, Creatine, AcetylCarnitine, Resveratrol
Working Memory2 Phosphatidylserine, Tyrosine
Leptin2 Zinc, Fish Oil, Melatonin
Sperm Quality2 Shilajit, AcetylCarnitine
HDL-C2 Green Tea Catechins, Inositol, Vitamin E, Magnesium, AcetylCarnitine
Power Output1 Vitamin D, Creatine, AcetylCarnitine, Resveratrol, Alpha GPC
Euphoric1 Vitamin E, Creatine
Infant Birth Weight1 Fish Oil
Gastrin1 Melatonin
Muscular Endurance1 Creatine
Cell Adhesion Factors (aka sCAM-11 Vitamin E, Fish Oil
Immunity (aka Immune system)1 Vitamin E
Muscle Carnitine Content1 AcetylCarnitine
Treatment of Hepatic Encephalopathy1 AcetylCarnitine
Hydration1 Creatine
Serum Magnesium1 Magnesium
Treatment of Myotonic Dystrophy1 Creatine
Bone Mineral Density (aka BMD)1 Creatine
Interleukin 41 Vitamin E
Dysmenorrhea1 Vitamin E
VO2 Max1 Green Tea Catechins, Cordyceps, Fish Oil, Creatine, AcetylCarnitine, Resveratrol
Fatigue Resistance1 Creatine
Photoprotection1 Fish Oil
Interferon Gamma1 Vitamin E
Fertility1 Inositol
Plasma Melatonin1 Melatonin
Endothelial Function1 Fish Oil
AdrenalineNeutral Melatonin
Exercise Capacity (with Heart Conditions)Neutral Creatine
Bleeding TimeNeutral Vitamin E
Aerobic ExerciseNeutral Creatine, AcetylCarnitine
Sleep LatencyNeutral Valeriana officinalis
Natural Killer Cell Content (aka NK cellNeutral Fish Oil
Postpartum DepressionNeutral Fish Oil
Pre-Eclampsia RiskNeutral Fish Oil
T Cell CountNeutral Fish Oil
Muscle Soreness (aka Delayed onset muscle sorenessNeutral Fish Oil
Insulin SecretionNeutral Fish Oil
Risk of StrokeNeutral Vitamin E
B cell countNeutral Fish Oil
Apolipoprotein BNeutral Fish Oil
PneumoniaNeutral Zinc
Serum T4Neutral Vitamin E
Symptoms of SchizophreniaNeutral Inositol
Exercise Capacity in COPDNeutral Creatine
Cognition (Omnivores)Neutral Creatine
CortisolNeutral Vitamin E, Phosphatidylserine, Fish Oil, Magnesium, Creatine, Melatonin
Lung FunctionNeutral Creatine
Treatment of Amyotrophic lateral sclerosis (ALS)Neutral Creatine
Metabolic RateNeutral Green Tea Catechins
Fat OxidationNeutral AcetylCarnitine
Treatment of COPDNeutral Creatine
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  • 2016-11-27 14:01:58: Cerebrolysin was removed.
  • 2016-11-27 14:01:46: Phenibut was removed.
  • 2016-11-27 14:00:48: Vinpocetine was removed.
  • 2016-11-27 13:59:59: Iodine was removed.
  • 2016-11-27 13:58:56: CILTEP was removed.
  • 2016-11-27 13:57:49: Nardostachys Jatamansi was removed.
  • 2016-11-27 13:57:34: Ashitaba was removed.
  • 2016-11-27 13:57:26: Vitamin B12 was removed.
  • 2016-11-27 13:56:50: 5-HTP was removed.
  • 2016-11-27 13:56:38: Folic Acid was removed.
  • 2016-11-27 13:56:29: Lutein was removed.
  • 2016-11-27 13:55:18: Oxaloacetate was removed.
  • 2016-11-27 13:54:55: Exercise was removed.
  • 2016-11-27 13:53:46: Dihexa was removed.
  • 2016-11-27 13:53:43: Meditation was removed.
  • 2016-11-27 13:53:38: Pyrroloquinoline quinone was added.
  • 2016-11-27 13:53:38: Notes of Pyrroloquinoline quinone was set to A redox agent that influences mitochondrial activity to a great extent. It signals to mitochondria for the great increase in mitochondrial biogenesis. The increases in mitochondria could greatly increases ATP output. Along with the extra protection to mitochondria, it could find synergy in the improvement of mitochondrial function through the use of CoQ10 and shilajit. With further improvement to the electron transport chain, ATP production could be improved. It has the added bonus of also increasing NGF, giving it the ability to increase cognition in nearly all aspects with ATP production and increased neurite outgrowth with neuron protection..
  • 2016-11-27 13:53:38: Dose quantity of Pyrroloquinoline quinone was set to 10.00.
  • 2016-11-27 13:53:38: Dose unit of Pyrroloquinoline quinone was set to 1.
  • 2016-11-27 13:53:38: Start date of Pyrroloquinoline quinone was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Pyrroloquinoline quinone was set to Can't tell.
  • 2016-11-27 13:53:38: Valeriana officinalis was added.
  • 2016-11-27 13:53:38: Notes of Valeriana officinalis was set to A natural herb used as a sleep aid. It does this by enhancing GABA signaling..
  • 2016-11-27 13:53:38: Dose quantity of Valeriana officinalis was set to 400.00.
  • 2016-11-27 13:53:38: Dose unit of Valeriana officinalis was set to 1.
  • 2016-11-27 13:53:38: Start date of Valeriana officinalis was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Valeriana officinalis was set to Can't tell.
  • 2016-11-27 13:53:38: Dihexa was added.
  • 2016-11-27 13:53:38: Dose quantity of Dihexa was set to 10.00.
  • 2016-11-27 13:53:38: Dose unit of Dihexa was set to 1.
  • 2016-11-27 13:53:38: Start date of Dihexa was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Dihexa was set to Can't tell.
  • 2016-11-27 13:53:38: Meditation was added.
  • 2016-11-27 13:53:38: Dose quantity of Meditation was set to 1.00.
  • 2016-11-27 13:53:38: Dose unit of Meditation was set to 8.
  • 2016-11-27 13:53:38: Start date of Meditation was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Meditation was set to Can't tell.
  • 2016-11-27 13:53:38: Dose unit of Cordyceps was set to 2.
  • 2016-11-27 13:53:38: Start date of Cordyceps was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Cordyceps was set to Can't tell.
  • 2016-11-27 13:53:38: Gotu Kola was added.
  • 2016-11-27 13:53:38: Notes of Gotu Kola was set to An herb with various different bodily benefits. It first and foremost increases BDNF and enhances NGF effects such as neuron survival and growth. One of its main mechanisms is being a cholecystokinin receptor agonist, which is responsible for its anxiolitic effects. It helps increase blood circulation and reduce the hardening of arteries allowing more oxygen and nutrients to the brain. Plus it aids the liver, regulating the metabolic processes that could support brain health. It shows synergy with Vitamin E..
  • 2016-11-27 13:53:38: Dose quantity of Gotu Kola was set to 100.00.
  • 2016-11-27 13:53:38: Dose unit of Gotu Kola was set to 1.
  • 2016-11-27 13:53:38: Start date of Gotu Kola was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Gotu Kola was set to Can't tell.
  • 2016-11-27 13:53:38: Turmeric was added.
  • 2016-11-27 13:53:38: Notes of Turmeric was set to A natural compound and the active ingredient in curcumin. It can increase BDNF, enhancing neurogenesis and synaptogenesis. It decreases inflammation in the brain, and decreases beta-amyloid, the primary cause a plaques in brain that lead to alzheimer's. It also has immune system benefits, protecting the nervous system from infection. Finally, it shows synergy with fish oil..
  • 2016-11-27 13:53:38: Dose quantity of Turmeric was set to 200.00.
  • 2016-11-27 13:53:38: Dose unit of Turmeric was set to 1.
  • 2016-11-27 13:53:38: Start date of Turmeric was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Turmeric was set to Can't tell.
  • 2016-11-27 13:53:38: Vitamin E was added.
  • 2016-11-27 13:53:38: Dose quantity of Vitamin E was set to 500.00.
  • 2016-11-27 13:53:38: Dose unit of Vitamin E was set to 4.
  • 2016-11-27 13:53:38: Start date of Vitamin E was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Vitamin E was set to Can't tell.
  • 2016-11-27 13:53:38: 5-HTP was added.
  • 2016-11-27 13:53:38: Notes of 5-HTP was set to The precursor to serotonin, which in turn produces melatonin. The increase in serotonin signalling in general can regulate mood and appetite. Serotonin signalling in the 5-HT2A specifically can have an influence on neurogenesis in the hippocampus, which helps reduce anxiety, depression, and aids memory. The increased production in melatonin can act as a sleep aid and decrease brain cell death, further enhancing neurogenesis..
  • 2016-11-27 13:53:38: Dose quantity of 5-HTP was set to 50.00.
  • 2016-11-27 13:53:38: Dose unit of 5-HTP was set to 1.
  • 2016-11-27 13:53:38: Start date of 5-HTP was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of 5-HTP was set to Can't tell.
  • 2016-11-27 13:53:38: Folic Acid was added.
  • 2016-11-27 13:53:38: Dose quantity of Folic Acid was set to 300.00.
  • 2016-11-27 13:53:38: Dose unit of Folic Acid was set to 3.
  • 2016-11-27 13:53:38: Start date of Folic Acid was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Folic Acid was set to Can't tell.
  • 2016-11-27 13:53:38: Inositol was added.
  • 2016-11-27 13:53:38: Notes of Inositol was set to A nutrient and a carbohydrate similar to glucose. It is synergistic with melatonin and could be used to aid sleep and reduce anxiety. It also increases the sensitivity of serotonin receptors, such as the 5-HT2A receptor responsible for neurogenesis..
  • 2016-11-27 13:53:38: Dose quantity of Inositol was set to 1.00.
  • 2016-11-27 13:53:38: Dose unit of Inositol was set to 2.
  • 2016-11-27 13:53:38: Start date of Inositol was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Inositol was set to Can't tell.
  • 2016-11-27 13:53:38: Lutein was added.
  • 2016-11-27 13:53:38: Notes of Lutein was set to A carotenoid that has studies showing it increases voluntary energy output based on behavior..
  • 2016-11-27 13:53:38: Dose quantity of Lutein was set to 10.00.
  • 2016-11-27 13:53:38: Dose unit of Lutein was set to 1.
  • 2016-11-27 13:53:38: Start date of Lutein was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Lutein was set to Can't tell.
  • 2016-11-27 13:53:38: NADH was added.
  • 2016-11-27 13:53:38: Notes of NADH was set to A redox agent that is made from vitamin B3. It primarily works in mitochondria; it controls the redox reactions in the Krebs Cycle and the electron transport chain. For this reason it is used to treat conditions in which more metabolic energy in the form of ATP is needed. For healthy individuals it could help increase ATP output in most mitochondrial processes. It has the added bonus of increasing natural dopamine production, increases mood and motivation. Plus it is often used to treat jet lag..
  • 2016-11-27 13:53:38: Dose quantity of NADH was set to 5.00.
  • 2016-11-27 13:53:38: Dose unit of NADH was set to 1.
  • 2016-11-27 13:53:38: Start date of NADH was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of NADH was set to Can't tell.
  • 2016-11-27 13:53:38: Pregnenolone was added.
  • 2016-11-27 13:53:38: Notes of Pregnenolone was set to A neurosteroid hormone that is known to trigger neurogenesis and synaptogenesis through a couple of mechanisms. It acts as a NMDA receptor agonist that helps create and reinforce synapses in the brain through a process known as LTP. It is known as the "mother hormone" being the precursor to many hormones including androgens, estrogens, progesterones, glucocorticoids, mineralocorticoids, DHEA, cortisol, and other neuroactive steroids. The cascade of hormones it produces, along with itself, it can induce neurogenesis, increase myelination, speed up neuronal repair, enhance synaptogenesis, boost energy, and halt aging..
  • 2016-11-27 13:53:38: Dose quantity of Pregnenolone was set to 5.00.
  • 2016-11-27 13:53:38: Dose unit of Pregnenolone was set to 1.
  • 2016-11-27 13:53:38: Start date of Pregnenolone was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Pregnenolone was set to Can't tell.
  • 2016-11-27 13:53:38: Pycnogenol was added.
  • 2016-11-27 13:53:38: Notes of Pycnogenol was set to The extract of pine bark that shows neuroprotective benefits. It's main mechanism for increasing mental performance is by modulating mNOS..
  • 2016-11-27 13:53:38: Dose quantity of Pycnogenol was set to 40.00.
  • 2016-11-27 13:53:38: Dose unit of Pycnogenol was set to 1.
  • 2016-11-27 13:53:38: Start date of Pycnogenol was set to 2016-11-27.
  • 2016-11-27 13:53:38: Effectiveness of Pycnogenol was set to Can't tell.
  • 2016-11-27 13:53:38: Epitalon was added.
  • 2016-11-27 13:53:38: Notes of Epitalon was set to A peptide with powerful anti-aging properties. Its main mechanism of action is increasing telomerase; telomeres are like caps of genetic material on the ends of chromosomes. Each time a cell divides through mitosis it loses some telomere length. The result of missing telomeres is programmed cell death, telomerase is an enzyme that rebuilds those telomere caps, preventing cell death. Because of the decreased cell death, it could increase life span and healing speed. The increased healing speed not only applies to wounds, but can accelerate muscle healing and support skin health in the process. It even can reduce cancer risk by an increase in natural melatonin production, as a result it could also aid in deep sleep..

Dosage Compound Form Frequency Dates Notes
400 mg 1X1,1,1,1,1,1,12016-11-27
A natural herb used as a sleep aid. It does this by enhancing GABA signaling.
10 mg 1X1,1,1,1,1,1,12016-11-27
A redox agent that influences mitochondrial activity to a great extent. It signals to mitochondria for the great increase in mitochondrial biogenesis. The increases in mitochondria could greatly increases ATP output. Along with the extra protection to mitochondria, it could find synergy in the improvement of mitochondrial function through the use of CoQ10 and shilajit. With further improvement to the electron transport chain, ATP production could be improved. It has the added bonus of also increasing NGF, giving it the ability to increase cognition in nearly all aspects with ATP production and increased neurite outgrowth with neuron protection.
100 mg 1X1,1,1,1,1,1,12016-11-27
An antioxidant extract that has been shown to increase BDNF and NGF related neurite outgrowth. It has cardiovascular benefits to aid in nutrient and oxygen transport to the brain. It aids the immune system protecting the brain from pathogen attacks. It contains caffeine which is an adenosine antagonist promoting wakefulness, increases epinephrine and norepinephrine enhancing mental stamina and alertness, and it modulates dopamine improving mood and motivation. It also has l-theanine, which is synergistic with caffeine in regards to smoothing out the jitters by modulating GABA. It also further modulates dopamine and increases levels of BDNF slightly.
2 g 2X1,1,1,1,1,1,12016-11-27
A carbohydrate that acts as a building block to many important compounds in the body. Firstly, it acts as a sugar, supplying direct full to cells. It is also the backbone of both DNA and RNA, allowing its production and replication at a healthy rate. Lastly it is a major component in ATP, allowing more of it to be directly synthesized. This allows proper protein construction, cell division, and cellular energy output.
50 mg 2X1,1,1,1,1,1,12016-11-27
A chemical that is seen as a cholinergic. It keeps the brain healthy by helping remove lipofuscins, age spots that show up on the brain, and beta-amyloid, a protein that forms plaques in the brain that are one of the components in alzheimer's. It also increases oxygen consumption in the brain, giving it greater metabolic energy.
200 mcg 1X1,1,1,1,1,1,12016-11-27
A peptide like noopept with powerful nootropic effects. It rapidly elevates dopaminergic and serotoninergic systems and stimulates the cholinergic and glutamatergic systems, sharply increasing motivation and mood, and enhancing learning, cognition, and alertness through these systems. It has a profound impact on BDNF and NGF levels, even increasing the sensitivity of TrkB receptors, increasing neurogenesis and synaptogenesis especially in the hippocampus and basal forebrain, having a vast number of benefits including enhanced reasoning, verbal fluency, mental clarity, recall speed, antidepressive and anxiolitic effects.
200 mcg 1X1,1,1,1,1,1,12016-11-27
A peptide very similar to semax, but more known for its anxiolitic effects. It has similar mechanisms to semax in modulating BDNF expression in the hippocampus and modulating catecholamines increasing cognition and reducing anxiety. However, it also modulates the immune system regarding T helper cells, which can protect the brain from infection and seems to have an impact on its anxiolytic effects.
200 mg 2X1,1,1,1,1,1,12016-11-27
A peptide with powerful anti-aging properties. Its main mechanism of action is increasing telomerase; telomeres are like caps of genetic material on the ends of chromosomes. Each time a cell divides through mitosis it loses some telomere length. The result of missing telomeres is programmed cell death, telomerase is an enzyme that rebuilds those telomere caps, preventing cell death. Because of the decreased cell death, it could increase life span and healing speed. The increased healing speed not only applies to wounds, but can accelerate muscle healing and support skin health in the process. It even can reduce cancer risk by an increase in natural melatonin production, as a result it could also aid in deep sleep.
40 mg 1X1,1,1,1,1,1,12016-11-27
The extract of pine bark that shows neuroprotective benefits. It's main mechanism for increasing mental performance is by modulating mNOS.
5 mg 1X1,1,1,1,1,1,12016-11-27
A neurosteroid hormone that is known to trigger neurogenesis and synaptogenesis through a couple of mechanisms. It acts as a NMDA receptor agonist that helps create and reinforce synapses in the brain through a process known as LTP. It is known as the "mother hormone" being the precursor to many hormones including androgens, estrogens, progesterones, glucocorticoids, mineralocorticoids, DHEA, cortisol, and other neuroactive steroids. The cascade of hormones it produces, along with itself, it can induce neurogenesis, increase myelination, speed up neuronal repair, enhance synaptogenesis, boost energy, and halt aging.
5 mg 2X1,1,1,1,1,1,12016-11-27
A redox agent that is made from vitamin B3. It primarily works in mitochondria; it controls the redox reactions in the Krebs Cycle and the electron transport chain. For this reason it is used to treat conditions in which more metabolic energy in the form of ATP is needed. For healthy individuals it could help increase ATP output in most mitochondrial processes. It has the added bonus of increasing natural dopamine production, increases mood and motivation. Plus it is often used to treat jet lag.
1 g 3X1,1,1,1,1,1,12016-11-27
A nutrient and a carbohydrate similar to glucose. It is synergistic with melatonin and could be used to aid sleep and reduce anxiety. It also increases the sensitivity of serotonin receptors, such as the 5-HT2A receptor responsible for neurogenesis.
500 iu 1X1,1,1,1,1,1,12016-11-27
200 mg 1X1,1,1,1,1,1,12016-11-27
A natural compound and the active ingredient in curcumin. It can increase BDNF, enhancing neurogenesis and synaptogenesis. It decreases inflammation in the brain, and decreases beta-amyloid, the primary cause a plaques in brain that lead to alzheimer's. It also has immune system benefits, protecting the nervous system from infection. Finally, it shows synergy with fish oil.
100 mg 1X1,1,1,1,1,1,12016-11-27
An herb with various different bodily benefits. It first and foremost increases BDNF and enhances NGF effects such as neuron survival and growth. One of its main mechanisms is being a cholecystokinin receptor agonist, which is responsible for its anxiolitic effects. It helps increase blood circulation and reduce the hardening of arteries allowing more oxygen and nutrients to the brain. Plus it aids the liver, regulating the metabolic processes that could support brain health. It shows synergy with Vitamin E.
1 g 2X1,1,1,1,1,1,12016-11-27
An adaptogenic herb grown in high altitudes. It most importantly increases metabolic energy in a number of ways. It opens up airways in the lungs allowing more oxygen in. It increases oxygen absorption in the lungs. It increases oxygen diffusion into cells, and it increases overall ATP output by donating adenosine to mitochondria. Along with the cognitive benefits of increased oxygen consumption, it also aids the immune system protecting the brain from pathogens. Finally, it aids the adrenal glands regulating both epinephrine and norepinephrine, stabilizing mental stamina and alertness.
1000 iu 1X1,1,1,1,1,1,12016-11-27
200 mg 2X1,1,1,1,1,1,12016-11-27
An antioxidant that has the unique ability to be both water and fat soluble. In that regard it could easily cross the blood brain barrier and deliver its antioxidant benefits and more. It shows up in the Kreb and can induce mitochondrial biogenesis to an extent, increasing ATP output. For these reasons, it is great at synergising with ALCAR because of a the mitochondrial enhancements, plus its added ability of increasing insulin release and insulin sensitivity, allowing ALCAR to aid in metabolising fatty acids. With all of these mechanisms it is excellent at improving cognition and processing speed.
150 mg 1X1,1,1,1,1,1,12016-11-27
A natural herb that is shown to slightly increase BDNF. BDNF is known to greatly increase both synaptogenesis and neurogenesis. It works in a very similar way to NGF because they are both considered neurotrophins. They works by protecting brain cells and increases their survival rate. It also acts as an antioxidant, further protecting neurons. Plus it is great at protect the liver from harmful toxins, this allows the liver to process and metabolize many other substances with greater effectiveness. This has the potential to increases the effects of many other items listed.
100 mg 1X1,1,1,1,1,1,12016-11-27
An herb whose purpose is to potentiate certain ingredients in the stack. It is highly synergistic with CoQ10 and PQQ. It works in the further aid of the electron transport chain in mitochondria, increases cellular energy and ATP output.
2 pill(s)Multivitamin 1X1,1,1,1,1,1,12016-11-27
15 mg 1X1,1,1,1,1,1,12016-11-27
200 mcg 1X1,1,1,1,1,1,12016-11-27
Helps counter iodine toxicity and oxidative stress, especially in the eyes. Helps aid thyroid function.
10 mg 2X1,1,1,1,1,1,12016-11-27
A peptide that has many mechanisms of action. It enhances the activity of acetylcholine and stimulates glutamine receptors allowing the brain to work at a faster pace. It also increases the amount of oxygen present in the brain, further increasing energy output. Finally it increases the levels of both BDNF and NGF. This promotes neuron survival, neuron growth, neurogenesis and synaptogenesis, acting as a potent neuroprotectant agent. And finally it increases brain hemisphere communication, increasing creative thought and reasoning.
150 mg 2X1,1,1,1,1,1,12016-11-27
A nutrient that makes up a part of RNA. In turn, it increases RNA activity and repairs genetic material. That helps with overall brain function by allowing the brain to produce proteins and enzymes that it needs, helping with functions like LTP. It enhances the neurite outgrowth caused by NGF. It also increases phosphatidylcholine, supporting the cell membrane, synaptic plasticity, production of neurites, the myelin sheath, and the supply of neurotransmitters. Another positive effect being the upregulation of dopamine receptors.
50 mg 3X1,1,1,1,1,1,12016-11-27
A phospholipid that shows up on all cell membranes. It is one of the best phospholipids for cell to cell communication and neuron repair. It therefore enables sound synaptic transmission, this allows synergy with omega-3s. Omega-3s could fit into the fatty acid "slots" in it causing a further boost in regulating synaptic transmission. Plus enhances the cardiovascular benefits experienced by omega-3s. It also can increase the activity of acetylcholine and dopamine, causing increased learning, memory, and motivation.
2000 mg 1X1,1,1,1,1,1,12016-11-27
EPA and DHA are fatty acids known to increase BDNF levels in the hippocampus. Disregarding water weight, the average human brain is 60% fat. Omega-3s therefore work as a very high quality building block for the brain. It regulates synaptic plasticity allowing neuronal cell transmission and increasing neurotransmitter release. It helps with neurogenesis and neurite outgrowth, neurites being dendrites and axons. It acts as an anti-inflammatory agent and an antioxidant, further protecting neurons. Finally, it shows synergies with phosphatidylserine, uridine, curcumin, green tea, and vitamin E.
400 mg 1X1,1,1,1,1,1,12016-11-27
Magnesium Glycine is a compound that contains both the mineral magnesium and the amino acid glycine. Magnesium can modulate NMDA receptors and increases BDNF levels, in turn it is known to aid in memory, regulating synaptic plasticity, and enhancing sleep quality. Glycine is known to signal in glycine receptors and some adenosine receptors, acting mainly as an inhibitory neurotransmitter. Because of it being inhibitory, it could be used as sleep aid; because it can signal to some adenosine receptors, it can increase BDNF to some extent. It shows some synergy with Vitamin D.
100 mg 1X1,1,1,1,1,1,12016-11-27
A synthetic analogue of CoQ10 that also acts in the electron transport chains in mitochondria. Because of this function, it could increase the output of ATP in neurons, enhancing cognition. Not only that, but it also has an influence on NGF, promoting the creation, survival, and growth of neurons. This is very apparent in its influence on axon creation and growth, which allows electrical impulses along neurons to move much faster, potentially increasing thinking speed. It is also known for increasing acetylcholine and slightly increasing dopamine and serotonin, increasing mood, focus and cognition. Plus it increases communication between the hemispheres of the brain, increasing creative thinking and reasoning.
50 mg 1X1,1,1,1,1,1,12016-11-27
An antioxidant that acts as a neuroprotant agent. CoQ10 is used to treat many neurodegenerative diseases such as parkinsons and alzheimers. It works as an optional co-enzyme in the electron transport chain in mitochondria. It greatly increases the speed in which electrons are carried between the enzymes that process ATP. Because of the ATP production, it is shown to be very beneficial to cardiovascular health. This aids the brain in both a direct energy increase, and an increase in oxygen and nutrient transport from the cardiovascular system. Plus it shows synergies with PQQ, shilajit, creatine, ALCAR, and alpha-lipoic-acid. PQQ increasing the amount of mitochondria and shilajit further boosting the electron transport chain.
2 g 1X1,1,1,1,1,1,12016-11-27
Creatine is an amino acid that affects ATP production. It donates a phosphorus atom to ADP, supplying extra energy to cells. Because of increased metabolic energy, it show efficacy in improving cognition. It also show synergy with alpha-lipoic acid.
500 mg 2X1,1,1,1,1,1,12016-11-27
An amino acid that acts as an antioxidant and a neuroprotectant. It has the ability to clear neurotoxins and keeps brain cells from dying. Along with the increase in acetylcholine, which enhances learning and memories, the clearance of neurotoxins improves neuronal communication and processing speed. It influences dopamine increasing mood and motivation. It also supports myelin to a great extent, aiding in myelinogenesis and repairing the myelin sheath. This allows much faster transmission of electrical impulses along neurons. Plus it increases NGF, allowing the survival of neurons, neurite outgrowth, synaptogenesis and a slight amount of neurogenesis. Finally, with synergies with tyrosine and alpha lipoic acid, it increases metabolism of fatty acids, supports mitochondrial functions, and increased ATP output.
2 mg 1X1,1,1,1,1,1,12016-11-27
A natural hormone used in the body's circadian rhythm. It acts as a powerful antioxidant that easily crosses the blood brain barrier. It aids in sleep and reduces brain cell death, increasing the quality of neurogenesis. It shows synergies with resveratrol, for AMPK activation, alpha-lipoic acid, for antioxidation, and galantamine for neuroprotection.
50 mg 1X1,1,1,1,1,1,12016-11-27
An antioxidant known for its anti-aging properties. It can increase lifespan and improve cognition by increasing cellular energy and reducing inflammation. It increases cellular energy mainly by acting as a vasodilator by increasing nitric oxide; it also increases insulin sensitivity, further enhancing metabolism. On top of that, it could increase norepinephrine which aids in alertness and mental stamina. Plus it is a serotonin receptor agonist giving it mood elevating properties. Finally it shows synergies with melatonin, for neuroprotection, and curcumin.
5 mg 2X1,1,1,1,1,1,12016-11-27
Also known as black pepper, its purpose being the enhancement of absorption of many of the other nootropics in this stack.
1 g 1X1,1,1,1,1,1,12016-11-27
A mushroom that greatly increases NGF levels. The increase in NGF has a lot of benefits to go along with it. It increases neuron survival rates when faced with physical trauma, toxins, and programmed cell death. It helps repair neurons that have already been damaged. It increases the number of neurites, axons and dendrites, and grows them. All of these mechanisms increase cognition through the stimulation of synaptogenesis and the triggering of neurogenesis. It also has an influence on the myelin sheath, greatly increasing the speed of electrical impulses in neurons, further increasing cognition.
350 mg 1X1,1,1,1,1,1,12016-11-27
An amino acid that produces monoamine neurotransmitters. The main point of it in this stack is its synergy with ALCAR, further increasing energy output. But moreover, it has the ability to aid in mental stamina and motivation. This is due to the increase production in dopamine, norepinephrine, and epinephrine.
50 mg 2X1,1,1,1,1,1,12016-11-27
A potent choline source that increases the supply of acetylcholine in the brain. Choline also supports cell membranes, synaptic transmission, and functions within the myelin sheath. It also increases HGH, which has some cognitive benefits, and supports lipolysis, supplying more energy to the brain.
4 mg 1X1,1,1,1,1,1,12016-11-27
An alkaloid that improve the quality of sleep. It works as a cholinergic, it inhibits acetylcholinerase, the enzyme that breaks down acetylcholine. Normally acetylcholine isn't even reabsorbed into the axon terminal where it is released. Instead it is broken down in the synaptic cleft. If it isn't broken down then the acetylcholine can stay linked to receptors. This type of mechanism is used medically to treat alzheimer's, but recreationally as a sleep aid. Because acetylcholine has such an influence on REM sleep, galantamine is often used to induce lucid dreaming, being aware of a dream.

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Potential Interactions
Some evidence suggests that adding vitamin E to fish oil may prevent fish oil-induced increase in blood sugar levels.
Refrences
  • Luostarinen R, Wallin R, Wibell L, et al. Vitamin E supplementation counteracts the fish oil-induced increase of blood glucose in humans. Nutr Res 1995; 15:953-68.
In a study of healthy men, supplementation with a large amount of zinc (142 mg per day) decreased magnesium absorption. Magnesium supplementation should therefore be considered for people taking large amounts of zinc, and possibly for those taking lower amounts.
Refrences
  • Spencer H, Norris C, Williams D. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 1994;13:479-84.

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