Vitamin B1 (thiamine) and magnesium work together in several different biochemical processes in the body. In patients who are deficient in both thiamine and magnesium, symptoms of thiamine deficiency may not respond to thiamine supplementation unless magnesium deficiency is also corrected. In addition, administration of large doses of thiamine can worsen magnesium deficiency. Magnesium supplementation should therefore be considered by people who are supplementing with thiamine.
- Gaby AR. Magnesium. In Gaby AR, Nutritional Medicine. Concord, NH, www.doctorgaby.com, 2011; chapter 27