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Mental Growth Stack

Cognitive Enhancement 22,655 Updated: 2017-12-0156 following ninjaeon
GOALS: Increase nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF). Improve mitochondrial support, energy levels, memory, and overall mental health. Limit use of stimulants.
  • 2018-05-21 23:40:38: Archive was set to 1.
  • 2018-05-13 22:21:33: Archive was set to 1.
  • 2018-02-05 12:41:16: Archive was set to 1.
  • 2018-02-05 12:41:09: Archive was set to 1.
  • 2017-12-01 02:55:52: Notes of N-Acetyl Semax Amidate was changed from 800mcg x 1/day subcutaneous injection (Semax). Previously 500mcg x 1/day subcutaneous injection (N-Acetyl Semax Amidate - discontinued use on June 27, 2016). In animals, Semax rapidly elevates the levels and expression of NGF, BDNF, and its signaling receptor TrkB in the hippocampus. It rapidly activates serotonergic and dopaminergic brain systems. It has been found to produce antidepressant-like and anxiolytic-like effects, as well as attenuate the behavioral effects of exposure to chronic stress.* N-Acetyl Semax Amidate is an experimental version of Semax which is acetylated to increase permeability across the blood-brain barrier and amidated to protect the peptide from enzymatic degradation. to 1000mcg x 1/day subcutaneous injection (Semax). Previously 500mcg x 1/day subcutaneous injection (N-Acetyl Semax Amidate - discontinued use on June 27, 2016). In animals, Semax rapidly elevates the levels and expression of NGF, BDNF, and its signaling receptor TrkB in the hippocampus. It rapidly activates serotonergic and dopaminergic brain systems. It has been found to produce antidepressant-like and anxiolytic-like effects, as well as attenuate the behavioral effects of exposure to chronic stress.* N-Acetyl Semax Amidate is an experimental version of Semax which is acetylated to increase permeability across the blood-brain barrier and amidated to protect the peptide from enzymatic degradation..
  • 2017-12-01 02:55:52: Dose quantity of N-Acetyl Semax Amidate was changed from 800.00 to 1000.
  • 2017-12-01 02:55:52: Effectiveness of N-Acetyl Semax Amidate was changed from Slight to Major.
  • 2017-12-01 02:55:52: A Purpose of N-Acetyl Semax Amidate was added (Depressed mood).
  • 2017-12-01 02:46:34: CBD Oil was added.
  • 2017-12-01 02:46:34: Notes of CBD Oil was set to 30mg (5 drops) x 1/day sublingual (Carun 6%). Cannabinoids promote neurogenesis in adult hippocampus and produces anxiolytic- and antidepressant-like effects.*.
  • 2017-12-01 02:46:34: Dose quantity of CBD Oil was set to 30.
  • 2017-12-01 02:46:34: Dose unit of CBD Oil was set to 1.
  • 2017-12-01 02:46:34: Start date of CBD Oil was set to 2017-09-01.
  • 2017-12-01 02:46:34: Effectiveness of CBD Oil was set to Moderate.
  • 2017-12-01 02:40:46: Notes of Vitamin K was changed from Increased dietary vitamin K intake is associated with fewer and less severe subjective memory complaints in older adults. to 100mcg x 1/day. Increased dietary vitamin K intake is associated with fewer and less severe subjective memory complaints in older adults..
  • 2017-12-01 02:40:46: Dose quantity of Vitamin K was changed from 1000.00 to 100.
  • 2017-12-01 02:40:46: Dose status of Vitamin K was cleared. Previous value was Under
  • 2017-12-01 02:40:46: Start date of Vitamin K was changed from 2017-11-30 to 2017-02-01.
  • 2017-12-01 02:40:46: A Purpose of Vitamin K was added (Memory problems).
  • 2017-11-30 22:36:03: Vitamin K was added.
  • 2017-11-30 22:36:03: Notes of Vitamin K was set to Increased dietary vitamin K intake is associated with fewer and less severe subjective memory complaints in older adults..
  • 2017-11-30 22:36:03: Dose quantity of Vitamin K was set to 1000.
  • 2017-11-30 22:36:03: Dose unit of Vitamin K was set to 3.
  • 2017-11-30 22:36:03: Dose status of Vitamin K was set to Under.
  • 2017-11-30 22:36:03: Start date of Vitamin K was set to 2017-11-30.
  • 2017-11-30 22:36:03: Effectiveness of Vitamin K was set to Can't tell.
  • 2016-08-15 22:14:38: Dose quantity of N-Acetyl Semax Amidate was changed from 500.00 to 800.
  • 2016-08-13 04:23:00: Notes of N-Acetyl Semax Amidate was changed from 500mcg x 1/day subcutaneous injection (N-Acetyl Semax Amidate). In animals, Semax rapidly elevates the levels and expression of NGF, BDNF, and its signaling receptor TrkB in the hippocampus. It rapidly activates serotonergic and dopaminergic brain systems. It has been found to produce antidepressant-like and anxiolytic-like effects, as well as attenuate the behavioral effects of exposure to chronic stress.* N-Acetyl Semax Amidate is an experimental version of Semax which is acetylated to increase permeability across the blood-brain barrier and amidated to protect the peptide from enzymatic degradation. to 800mcg x 1/day subcutaneous injection (Semax). Previously 500mcg x 1/day subcutaneous injection (N-Acetyl Semax Amidate - discontinued use on June 27, 2016). In animals, Semax rapidly elevates the levels and expression of NGF, BDNF, and its signaling receptor TrkB in the hippocampus. It rapidly activates serotonergic and dopaminergic brain systems. It has been found to produce antidepressant-like and anxiolytic-like effects, as well as attenuate the behavioral effects of exposure to chronic stress.* N-Acetyl Semax Amidate is an experimental version of Semax which is acetylated to increase permeability across the blood-brain barrier and amidated to protect the peptide from enzymatic degradation..
  • 2016-08-13 04:20:48: End date of N-Acetyl Semax Amidate was cleared. Previous value was 2016-06-27
  • 2016-08-13 04:20:23: End date of N-Acetyl Semax Amidate was set to 2016-06-27.
  • 2016-08-13 04:20:23: Effectiveness of N-Acetyl Semax Amidate was set to Slight.

Dosage Compound Form Frequency Dates Notes
30mg 1X1,1,1,1,1,1,12017-09-01
30mg (5 drops) x 1/day sublingual (Carun 6%). Cannabinoids promote neurogenesis in adult hippocampus and produces anxiolytic- and antidepressant-like effects.*
100mcg 1X1,1,1,1,1,1,12017-02-01
100mcg x 1/day. Increased dietary vitamin K intake is associated with fewer and less severe subjective memory complaints in older adults.
Purpose: Memory problems
1000mcg 1X1,1,1,1,1,1,12015-12-02
1000mcg x 1/day subcutaneous injection (Semax). Previously 500mcg x 1/day subcutaneous injection (N-Acetyl Semax Amidate - discontinued use on June 27, 2016). In animals, Semax rapidly elevates the levels and expression of NGF, BDNF, and its signaling receptor TrkB in the hippocampus. It rapidly activates serotonergic and dopaminergic brain systems. It has been found to produce antidepressant-like and anxiolytic-like effects, as well as attenuate the behavioral effects of exposure to chronic stress.* N-Acetyl Semax Amidate is an experimental version of Semax which is acetylated to increase permeability across the blood-brain barrier and amidated to protect the peptide from enzymatic degradation.
Purpose: Depressed mood
300mg 1X1,1,1,1,1,1,12016-01-06
300mg x 1/day. Enhances NGF-mediated neurite outgrowth and synaptogenesis (formation of synapses between neurons).*
500mg 2X1,1,1,1,1,1,12015-11-22
500mg x 2/day (Centella Asiatica Extract 5% Saponin). Enhances the activities of NGF and increases BDNF. Increases connections between neurons (dendritic branching). Neuroprotective and regenerates damaged neurons. Improves memory, mood, and attention while lowering anxiety.*
500mgAshitaba 1X1,1,1,1,1,1,12015-12-02
500mg x 1/day (5:1 Extract). Shown to increase NGF.*
1ml ,,,,,,2015-08-01
1000mcg (1mL) x 1/month subcutaneous injection (Cyanocobalamin Vitamin B12). Increases BDNF when combined with Fish Oil for treating Vitamin B12 and Omega-3 deficiency. Vitamin B12 deficiency presents as nonspecific symptoms of fatigue, lassitude, malaise, vertigo, and cognitive impairment that could be attributed to aging.*
2cups 2X1,1,1,1,1,1,12015-10-01
2 cup x 2-4/day. I switch to decaf in the afternoons or when I want to minimize caffeine. Shown to potentiate NGF-induced neuritogenesis (formation of neurites).*
25mg 07:00 am(Daily) - 1X1,1,1,1,1,1,12015-09-24
25mg x 1/day in morning (or up to 100mg as needed for wakefulness). Wakefulness-promoting agent (or eugeroic) used off-label by those wishing to avoid fatigue. In healthy individuals, improves some aspects of working memory, such as digit span, digit manipulation and pattern recognition memory. Modafinil is a prescription drug indicated for narcolepsy and shift work sleep disorder. It was developed from Adrafinil which is available as a supplement with similar effects (I prefer Modafinil).* When taking in conjunction with N-Acetyl Semax Amidate, I will take no more than a 100mg dose due to possible increase of blood pressure.
1pill(s)Muti-Vitamin 2X1,1,1,1,1,1,12015-09-03
1 tablet x 2/day (The Vitamin Shoppe "Ultimate Man" Multi-Vitamin). I chose this formula due to its value and for containing adequate amounts of Zinc (25mg) and Vitamin A (5,000iu). Zinc has been shown to increase NGF while Vitamin A modulates the expression of NGF receptors and the sensitivity to NGF.* It also contains bioflavonoids 100mg ("fruit and veggie blend"), Green Tea Extract 50mg, Grape Seed Extract 50mg, Black Pepper Concentrate 5mg (aka Piperine), Vitamin D 1000iu, and more.
300mg 1X1,1,1,1,1,1,12015-08-27
300mg x 1/day (Uridine Monophosphate). Enhances the neurite outgrowth produced by NGF. Increases acetylcholine (ACh) level and release. Modulates stimulant-induced release of dopamine. Synergistic with choline to improve cognitive deficits.*
300mgPolygonatum 1X1,1,1,1,1,1,12015-08-27
300mg x 1/day. Root powder, also known as Solomon's Seal. Increases NGF & BDNF.* Used for thousands of years for its healing and restorative potential.
300mgCodonopsis 1X1,1,1,1,1,1,12015-08-25
300mg x 1/day. Root powder of the Bonnet Bellflower. Increases NGF & BDNF. Inhibits the acetylcholinesterase (AChE) enzyme from breaking down acetylcholine. Increases phosphorylated cAMP response element binding protein (p-CREB), resulting in improving long-term memory.*
300mg 1X1,1,1,1,1,1,12015-08-25
300mg x 1/day (Root 5:1 Extract Powder). Increases NGF & BDNF. Improves learning and memory by preventing reductions in brain neurotransmitter levels including noradrenaline. Increases choline acetyltransferase (ChAT), an enzyme involved in acetylcholine (ACh) synthesis. Has fast acting antidepressive effects by hindering NMDA receptor signalling.*
350mg 1X1,1,1,1,1,1,12015-08-24
350mg x 1/day (Dimethylaminoethanol Bitartrate providing approx. 37% DMAE). Antioxidant naturally found in fish. A precursor of choline, which in turn allows the brain to optimize the production of acetylcholine (ACh) that is a primary neurotransmitter involved in learning and memory. Was used to treat ADHD (improve focus) in the 60's and 70's, with positive results comparable to Ritalin.*
500mgCurcumin 1X1,1,1,1,1,1,12015-08-24
500mg x 1/day (Extract from Turmeric). Increases BDNF. Neuroprotective against certain types of induced neuronal cell death. Synergistic with Fish Oil's anti-inflammatory effects.*
10mg 1X1,1,1,1,1,1,12015-08-24
10mg x 1/day. Active component and extract of Black Pepper, inhibits glucuronidation in the liver which would prevent uptake of certain supplements. Piperine increases the bioavailability of Curcumin by 2000% and Coenzyme Q10 by 30%. It reverses corticosterone induced reduction in BDNF mRNA expression in cultured hippocampal neurons.*
100mg 1X1,1,1,1,1,1,12015-08-22
100mg x 1/day. Present primarily in the mitochondria, it is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). Protects from free radical damage.
100mg ,,,,,,
100mg x 1 in morning as needed (approx. 1-2/week). Structurally similar to Caffeine, preliminary evidence suggests that it activates similar signalling pathways. Evidence suggests less tolerance with theacrine than caffeine. May have stress reducing properties at low doses.
300mg 1X1,1,1,1,1,1,1
300mg x 1/day (Alpha-GPC 50% Powder). Increases the levels of the neurotransmitter acetylcholine (ACh) in the brain, improving memory and communication between neurons. Taking in conjunction with equal amount of Citicoline.
1Unit(s)Exercise ,,,,,,2015-07-29
Exercise appears to boost the size of the hippocampus (the brain area involved in verbal memory and learning), increase mitochondrial biogenesis, and increase BDNF.* If you're considering taking unproven supplements or research chemicals, then consider regular exercise as well (since it's likely safer, cheaper, synergetic, and effective).
400mg ,,,,,,
200mg x 2/day. Synergetic with Coenzyme Q10 to speed and augment electron transfer within mitochondria, increasing cellular energy.* (Temporarily discontinued as of 12/6 due to supplier out of stock)
2tbsp ,,,,,,
2-4 tbsp. per day, used as cooking oil and/or added to food. Ketone bodies, such as those found in the medium chain triglycerides (MCTs) in coconut fat, are an effective alternative energy substrate for the brain.*
2000mg ,,,,,,
667mg x 3/day. Increases BDNF. Bioavailable form of Magnesium (Mg) which crosses the blood-brain barrier (BBB), shown to improve memory in normal and aging animals. Also protects cognitive function and synaptic plasticity.*
15mg ,,,,,,
15mg x 1/day. Increases NGF and BDNF in the hippocampus.* Peptide that is regarded as one of the most effective and strongest of all the nootropic supplements, suggested to be up to 1000x more powerful than Piracetam.
200mg ,,,,,,
200mg x 1/day. Naturally found in fish, phosphatydilserine (PS) is one of the phospholipids which play an important functional role in membrane-related processes in the brain.*
1pill(s) ,,,,,,
1/day (30 billion live cultures per capsule). Poorer gut health is correlated with more severe neurological and cognitive deficits such as nervousness, memory loss, forgetfulness, and confusion.*
5000iu ,,,,,,
5000iu x 1/day. Increases NGF. Low Vitamin D concentrations may increase the risk of cognitive decline.* Recently reduced from a year of daily 10000iu supplementation due to finally increasing Vitamin D blood lab results well within "normal" range.
20mgPyrroloquinoline Quinone (Bio PQQ) ,,,,,,
20mg x 1/day (Pyrroloquinoline Quinone Disodium Salt, also known as "BioPQQ"). Stimulates NGF synthesis and secretion, as well as mitochondrial biogenesis.*
300mg ,,,,,,
300mg x 1/day. Increases the levels of the neurotransmitter acetylcholine (ACh) in the brain, improving memory and communication between neurons.
4g ,,,,,,
2g x 2/day (myo-inositol). Reported to reverse desensitization of serotonin receptors and significantly reduced scores of OCD symptoms compared with placebo.* Inositol is a carbohydrate that's half as sweet as sugar, so I use it in lieu of sugar in hot tea. Gradually increasing dosage reduces gastrointestinal side-effects.
1000mg ,,,,,,
1000mg x 1 capsule taken once per week. As recommended in "The Depression Cure" book by Stephen Ilardi Ph.D. as a Gamma-Linolenic Acid (GLA) source.*
2000mg ,,,,,,
1 x 1000 mg taken 2/day with meals (The Vitamin Shoppe "Omega 3 Fish Oil"). DHA such as found in Fish Oil increases BDNF. Each of this brand's capsules contain 840mg EPA/DHA for 1680mg total EPA/DHA per day. Necessary to optimizing balance of Omega-3/Omega-6 long-chain polyunsaturated fatty acid ratio for proper neurodevelopment and cognitive functions.*
400mg ,,,,,,
400mg x 1/day. Increases mitochondrial biogenesis.* Alpha Lipoic Acid (ALA) is an antioxidant made by the body found in every cell, where it helps turn glucose into energy. Commonly combined synergistically with Acetyl-L-Carnitine (ALCAR).
250mg ,,,,,,
250mg x 1/day. Acetyl-L-Carnitine (ALCAR) increases NGF in the hippocampus and energy production in the mitochondria. Increases choline acetyltransferase (ChAT) activity, an enzyme involved in acetylcholine synthesis.* ALCAR is a powerful antioxidant and neuro-protective agent.
2g ,,,,,,
1g x 2/day. Using Lion's Mane Mushroom (hericium erinaceus) 10x water/ethanol extract powder. Promotes NGF gene expression and synthesis in the brain.*
100mg ,,,,,,
100mg x 1/day. Stimulator of NGF synthesis.* Transporter in the electron transport chain of mitochondria and increases the production of adenosine triphosphate (ATP). Promoted commercially as a synthetic analog of Coenzyme Q10.

Potential Dosage Guidelines

Previously Taken

Dosage Compound Form Frequency Dates Notes
600mg 1X1,1,1,1,1,1,12015-08-22 to
2015-09-24
200mg 1X1,1,1,1,1,1,12015-07-29 to
2015-08-22
8mg 1X1,1,1,1,1,1,12015-08-24 to
2015-10-05
500mg 1X1,1,1,1,1,1,12015-10-02 to
2015-10-09
500mg x 1/day (Ginkgo Biloba 4:1 Extract). Improves expression of NGF, BDNF, and Neurotrophin-3 (NT-3). NT-3 stimulates nerve growth in neurons that are not affected by NGF. Increases uptake of serotonin into neurons. Shown to be capable of producing improvement in memory and attention in healthy individuals.* (Discontinued on 10/09/15 due to allergy)

Potential Dosage Guidelines

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Mental Growth Stack



Current Therapies Date Added Time From Time To Notes

 

Current Activities Date Added Time From Time To Notes

 

Acceptable/Suspect Foods Date Added Time From Time To Notes

 

203 Potential Effects from this Stack

Effect OnScaleContributors
Cognition8 L-Theanine, Ginkgo biloba, Modafinil (Provigil), Alpha GPC, Noopept, Phosphatidylserine, Citicoline (CDP-Choline), AcetylCarnitine
Memory6 Ginkgo biloba, Modafinil (Provigil), Polygala Tenuifolia, Noopept, Phosphatidylserine, Citicoline (CDP-Choline), Fish Oil
Insulin Sensitivity6 Vitamin K, Curcumin, Magnesium, Vitamin D, Inositol, Fish Oil, AcetylCarnitine
Attention4 Ginkgo biloba, Modafinil (Provigil), Phosphatidylserine, Citicoline (CDP-Choline), Fish Oil, AcetylCarnitine
Working Memory3 Ginkgo biloba, Modafinil (Provigil), Polygala Tenuifolia, Coconut Oil, Phosphatidylserine
Sleep Quality2 Ginkgo biloba, Magnesium, Lions Mane
Free Testosterone2 Shilajit, Magnesium, Phosphatidylserine, Vitamin D, Fish Oil, AcetylCarnitine
Lean Mass2 Vitamin D, Fish Oil, AcetylCarnitine
Anaerobic Exercise2 Phosphatidylserine, AcetylCarnitine
HDL-C2 Curcumin, Magnesium, Inositol, AcetylCarnitine
Sperm Quality2 Shilajit, AcetylCarnitine
Calmness2 L-Theanine, Ginkgo biloba, Modafinil (Provigil)
Power Output1 Alpha GPC, Vitamin D, AcetylCarnitine
Growth Hormone1 Alpha GPC
Anti-Oxidant Enzyme Profile1 Curcumin
Motivation1 Modafinil (Provigil)
Fertility1 Inositol
Cell Adhesion Factors (aka sCAM-11 Fish Oil
Treatment of Hepatic Encephalopathy1 AcetylCarnitine
Muscle Carnitine Content1 AcetylCarnitine
Infant Birth Weight1 Fish Oil
Photoprotection1 Fish Oil
Endothelial Function1 Fish Oil
Alertness1 Modafinil (Provigil)
Serum Magnesium1 Magnesium
Blood Flow1 Ginkgo biloba, Fish Oil
Ocular Blood Flow1 Ginkgo biloba
Euphoric1 Ginkgo biloba
Stroke Recovery RateNeutral Ginkgo biloba
Postpartum DepressionNeutral Fish Oil
T Cell CountNeutral Fish Oil
Apolipoprotein BNeutral Fish Oil
LibidoNeutral Ginkgo biloba
Pre-Eclampsia RiskNeutral Fish Oil
BruisingNeutral Vitamin K
Symptoms of SchizophreniaNeutral Inositol
Insulin SecretionNeutral Fish Oil
LeptinNeutral Fish Oil
Muscle Soreness (aka Delayed onset muscle sorenessNeutral Fish Oil
VO2 MaxNeutral Curcumin, Fish Oil, AcetylCarnitine
Verbal FluencyNeutral Ginkgo biloba, Polygala Tenuifolia
Natural Killer Cell Content (aka NK cellNeutral Fish Oil
Symptoms of TinnitusNeutral Ginkgo biloba
Intraocular Pressure (aka IOP)Neutral Ginkgo biloba
Aerobic ExerciseNeutral AcetylCarnitine
LDL-CNeutral Curcumin, AcetylCarnitine
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