Health Notes & References
The base of this stack is "Lexapro" (Escitalopram). There are many things you can do to make sure you're getting the full potential from SSRI antidepressants. Research shows that if you have a low amount of serotonin in your reserves than SSRIs have a lower chance of success. So what you want to do is make sure your body is optimally synthesizing and producing serotonin. I'll list all the supplements and reasoning below:
Fish Oil: EPA potentially increases serotonin release from presynaptic neurons by reducing E2 series prostaglandins. DHA also influences serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons
Vitamin D: A very common deficiency. Vitamin D activates tryptophan hydroxylase 2 which synthesizes serotonin in the brain.
Semax: This peptide has been shown to increase serotonin turnover.
Selank: Enhances the 5-HT metabolism in the brain stem.
The next step is to make sure your dopamine system will be less affected by your SSRI. SSRIs have been shown to reduce the firing rate of dopamine and this is most likely the cause of SSRI fatigue, apathy, and possibly sexual anhedonia:
Emoxypine: This is a Russian drug and strong antioxidant. It increases the binding capabilities of benzodiazepine and GABA neurons which will potentiate any drugs that act on these neurons (xanax, valium, alcohol, phenibut, etc). It also increases the overall dopamine content of the brain.
Semax: This peptide has been found to potentiate the release of dopamine from stimulatory drugs. It is a good addition especially in combination with amphetamine, caffeine, methylphenidate, etc...
Kudzu Root: You specifically want the "puerarin" from this extract. What this does is antagonize (deactivate in a sense) the 5-HT2C receptor which SSRIs activate initially. 5-HT2C activation of this receptor by serotonin inhibits dopamine and norepinephrine release in certain areas of the brain (again, one of the reasons why SSRIs cause apathy, fatigue, sexual side effects). Antagonizing this specific receptor actually increases the release of dopamine and norepinephrine, allowing you to maintain energy levels while still getting the anxiolytic benefits of SSRIs.
The rest of the supplements in this stack provide great general health and address common deficiencies:
Magnesium: Another very common deficiency that is just as bad as vitamin D. Magnesium prevents bruxism which can be caused by SSRIs. It also is a NMDA antagonist and can help prevent tolerance and excitotoxicity in the brain.
EGCg: A very good supplement that combats free radicals and has also been shown to repair the "reward system/pathways" in the brain.
Aged Garlic Extract: A very good supplement to maintain heart health in combination with fish oil. This is a must for anyone taking drugs and especially stimulants.