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Depression Stack

General Health Stack 1,289  
Almost everyone have been through the stage of depression once in their lives already. As we all know, it may interfere with one's daily activities, the way we think, talk, and act are also affected. Depression does not only define being in a state of sadness but is much more than that. Some people define depression as "living in a black hole" or having a feeling of impending doom. Signs of symptoms of which include feelings of helplessness and hopelessness, loss of interest in daily activities, appetite or weight changes, sleep changes, anger or irritability, loss of energy, self-loathing, reckless behavior, concentration problems, and unexplained aches and pains. According to research or other evidence, the following self-care steps may be helpful.

Health Notes & References

This stack has no notes or references yet.
  • 2018-05-13 22:21:32: Archive was set to 1.
  • 2018-02-05 12:41:16: Archive was set to 1.
  • 2018-02-05 12:41:08: Archive was set to 1.
Supplements 26 Supplements
Dosage Compound Class Frequency Dates Notes
Studies show, the addition of a zinc supplement enhanced the beneficial effects of antidepressants.
Yohimbine (the active component of yohimbe) inhibits monoamine oxidase and therefore may be beneficial in treating depression.
Vervain is a traditional herb used for depression.
Pumpkin seeds contain L-tryptophan, and for this reason have been suggested to help remedy depression.
Phosphatidylserine affects the levels of neurotransmitters in the brain related to mood and has been shown in research to reduce the severity of depression.
One study suggested that supplementing with NADH may help people with depression.
See a doctor for evaluation. Taking folic acid can help correct deficiencies associated with depression.
Damiana has traditionally been used to treat people with depression.
In a few case reports, chromium has improved mood in people with a type of depression called dysthymic disorder.
Taken with vitamin D, calcium significantly improved mood in people without depression in one study.
500 mg twice a day. In a double-blind study, the combination of vitamin C and an antidepressant drug (fluoxetine) was significantly more effective than the antidepressant alone.
Studies show of patients with depression, supplementation with curcumin significantly improved depression, compared with a placebo.
100 mcg per day. Selenium deficiency may contribute to depression. Taking selenium can counteract this deficiency and improve depression symptoms.
1,600 mg daily. SAMe appears to raise levels of dopamine, an important neurotransmitter in mood regulation.
3 to 4 grams L-phenylalanine or 150 to 200 mg of DL-phenylalanine daily. Studies show, depressed people given L-phenylalanine experienced results comparable to those produced by an antidepressant.
.25 to 10 mg daily under medical supervision. Melatonin might help relieve depression. However, there is a possibility that it could exacerbate depression, so it should only be used for this purpose under a doctor's supervision.

Consult your doctor

. Some people with depression have been found to improve with tyrosine.
3 to 6 grams per day. Several controlled trials have found L-tryptophan as effective as antidepressant medications. Depressed people should consult a doctor before use.
12 grams of inositol daily. People with depression may have lower levels of inositol. Supplementing with this nutrient may correct a deficiency and improve depression symptoms.
240 mg daily. Ginkgo may alleviate depression in elderly people not responding to antidepressant drugs.
9.6 grams omega-3 fatty acids per day. Depressed people have been reported to have low amounts of omega-3 fatty acids. Taking fish oil can replenish stores and stave off depression.
Some studies have reported lower DHEA levels in depressed people. However, DHEA appears to be effective for only a minority of depressed people.
Acetyl-L-carnitine has been shown in several studies to significantly reduce depression symptoms in seniors.
Depression has been linked to serotonin imbalances in the brain. Supplementing with 5-HTP may increase serotonin synthesis and reduce symptoms.
20 mg twice daily. Oral contraceptives can deplete the body of vitamin B6, a nutrient needed for normal mental functioning. In such cases, vitamin B6 supplementation may improve mood.
1 to 2 grams daily EPA or 9.6 grams daily of total omega-3 fatty acids. Found in fish oil, EPA has been shown to relieve depression symptoms in some studies.

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Depression Stack

Potential Interactions

Long-term supplementation with vitamin B6 alone might reduce blood folic acid levels. Therefore, people with elevated blood homocysteine levels should supplement with both folic acid and vitamin B6.
  • Mansoor MA, Kristensen O, Hervig T, et al. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate. Scand J Clin Lab Invest 1999;59:139-46.
Vitamin D’s most important role is maintaining blood levels of calcium. Therefore, many doctors recommend that those supplementing with calcium also supplement with 400–1,200 IU of vitamin D per day.
  • Norman AW. Intestinal calcium absorption: a vitamin D-hormone-mediated adaptive response. Am J Clin Nutr 1990;51:290-300.
Zinc competes for absorption with calcium. A multimineral supplement will help prevent mineral imbalances.
  • Argiratos V, Samman S. The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects. Eur J Clin Nutr 1994;48:198-204.
Vitamin C appears to convert sodium selenite (a form of selenium used for supplementation) to elemental selenium, making it unavailable for absorption. This interaction occurred when 1 g of vitamin C was taken with sodium selenite on an empty stomach, but not when these nutrients were taken together with a meal. Vitamin C does not appear to interact with selenomethionine, another commonly used form of supplemental selenium.
  • Robinson MF,Thomson CD,Huemmer PK. Effect of a megadose of ascorbic acid, a meal and orange juice on the absorption of selenium as sodium selenite. The New Zealand medical journal. 1985 Aug;98(784):627-9
  • Ip C. Interaction of vitamin C and selenium supplementation in the modification of mammary carcinogenesis in rats. Journal of the National Cancer Institute. 1986 Jul;77(1):299-303

Check-In Posts

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Potential Effects from Stack

Cognition5 Zinc, Phosphatidylserine, Tyrosine, Ginkgo biloba, AcetylCarnitine
Memory4 Phosphatidylserine, Chromium, Melatonin, Ginkgo biloba, Fish Oil
Insulin Sensitivity4 Zinc, Chromium, Vitamin C, Melatonin, Inositol, Fish Oil, AcetylCarnitine
Leptin2 Zinc, Melatonin, Fish Oil
Working Memory2 Phosphatidylserine, Tyrosine, Ginkgo biloba
Cortisol2 Yohimbine, Phosphatidylserine, Vitamin C, Melatonin, Ginkgo biloba, Fish Oil, 5-HTP
Sleep Quality2 Melatonin, Ginkgo biloba
Sperm Quality2 Vitamin C, AcetylCarnitine
Attention2 Phosphatidylserine, Melatonin, Ginkgo biloba, Fish Oil, AcetylCarnitine
Blood Flow2 Vitamin C, Ginkgo biloba, Fish Oil
Anaerobic Exercise2 Phosphatidylserine, Chromium, AcetylCarnitine
Plasma Melatonin1 Melatonin
Gastrin1 Melatonin
Plasma Vitamin C1 Vitamin C
Libido1 Chromium, Ginkgo biloba
Calmness1 Ginkgo biloba
Photoprotection1 Fish Oil
Infant Birth Weight1 Fish Oil
Treatment of Hepatic Encephalopathy1 AcetylCarnitine
Muscle Carnitine Content1 AcetylCarnitine
Endothelial Function1 Fish Oil
Cell Adhesion Factors (aka sCAM-11 Fish Oil
HDL-C1 Inositol, AcetylCarnitine
Euphoric1 Ginkgo biloba
Ocular Blood Flow1 Ginkgo biloba
Fertility1 Inositol
Growth Hormone1 Melatonin
Erections1 Yohimbine
Free Testosterone1 Zinc, Phosphatidylserine, Chromium, Fish Oil, AcetylCarnitine
Lean Mass1 Yohimbine, Chromium, Fish Oil, AcetylCarnitine
Natural Killer Cell Content (aka NK cellNeutral Fish Oil
Neutral Zinc, Yohimbine, Vervain, Pumpkin, Phosphatidylserine, NADH, Folic Acid, Damiana, Chromium, Calcium, Vitamin C, Turmeric, Selenium, SAMe, Phenylalanine, Melatonin, Tyrosine, Tryptophan, Inositol, Ginkgo biloba, Fish Oil, DHEA, AcetylCarnitine, 5-HTP, Vitamin B6
Pre-Eclampsia RiskNeutral Fish Oil
T Cell CountNeutral Fish Oil
PneumoniaNeutral Zinc
Postpartum DepressionNeutral Fish Oil
Symptoms of SchizophreniaNeutral Inositol
Stroke Recovery RateNeutral Ginkgo biloba
Apolipoprotein BNeutral Fish Oil
Verbal FluencyNeutral Ginkgo biloba
Intraocular Pressure (aka IOP)Neutral Ginkgo biloba
IGF-1 (aka Insulin-like growth factor-1)Neutral Zinc, Inositol, Fish Oil
Muscle Soreness (aka Delayed onset muscle sorenessNeutral Fish Oil
Insulin SecretionNeutral Fish Oil
AdrenalineNeutral Melatonin
B cell countNeutral Fish Oil
Total CholesterolNeutral AcetylCarnitine
Power OutputNeutral Yohimbine, Chromium, AcetylCarnitine
Exercise-Induced Immune SuppressionNeutral Vitamin C
Aerobic ExerciseNeutral Vitamin C, AcetylCarnitine
CreatinineNeutral Chromium
Liver EnzymesNeutral Chromium
Muscular EnduranceNeutral Chromium
Food IntakeNeutral Chromium
Fat OxidationNeutral AcetylCarnitine
VO2 MaxNeutral Vitamin C, Fish Oil, AcetylCarnitine
Anti-Oxidant Enzyme ProfileNeutral Chromium
Protection from SmokingNeutral Vitamin C
Serum Albumin-1 AcetylCarnitine
Hematocrit-1 AcetylCarnitine
LDL-C-1 Zinc, AcetylCarnitine
Hemoglobin-1 AcetylCarnitine
Homocysteine-1 Fish Oil
Lactate Production-1 AcetylCarnitine
TNF-Alpha (aka TNF-α-1 Fish Oil
Numerical Memory-1 Ginkgo biloba
Ammonia-1 AcetylCarnitine
Symptoms of Systemic Lupus Erythematosus-1 Fish Oil
Symptoms of Bipolar Disorder (aka Manic-depressive disorder)-1 Fish Oil
Natural Killer Cell Activity-1 Fish Oil
Exercise-Induced Oxidation-1 AcetylCarnitine
Platelet Aggregation-1 Fish Oil
Symptoms of Intermittent Claudication-1 AcetylCarnitine
Symptoms of Alzheimers-1 Inositol, Ginkgo biloba, Fish Oil
Symptoms of Acute Mountain Sickness-1 Ginkgo biloba
Noradrenaline (aka norepinephrine)-1 Melatonin
Stomach Ulcers-1 Melatonin
Alertness-1 Melatonin
Prostate Cancer Risk-1 Selenium
vLDL-C-1 Chromium, Fish Oil
General Oxidation-1 Vitamin C
Heart Rate-1 Yohimbine, Phosphatidylserine, Chromium, Vitamin C, Melatonin, Tyrosine, Ginkgo biloba, Fish Oil, AcetylCarnitine
Symptoms of Tinnitus-1 Melatonin, Ginkgo biloba
Insomnia-1 Melatonin
Mucositis-1 Zinc
Acne-1 Zinc
Lipid Peroxidation-1 Zinc, Chromium, Vitamin C, Fish Oil, AcetylCarnitine
Cancer Mortality-1 Melatonin
Panic Attacks-1 Inositol
Triglycerides-1 Inositol, AcetylCarnitine
Symptoms of Jet Lag-1 Melatonin
Appetite-2 Chromium, 5-HTP
C-Reactive Protein-2 Zinc, AcetylCarnitine
Anxiety-2 Yohimbine, Melatonin, Inositol, Ginkgo biloba, Fish Oil
Cognitive Decline-2 Phosphatidylserine, Ginkgo biloba
Fecal Weight-2 Inositol, 5-HTP
Fat Mass-2 Yohimbine, Chromium, Vitamin C, Fish Oil, AcetylCarnitine
Muscle Damage-3 Phosphatidylserine, Vitamin C, Melatonin, Fish Oil, AcetylCarnitine
Blood Pressure-3 Zinc, Yohimbine, Phosphatidylserine, Chromium, Melatonin, Tyrosine, Inositol, Ginkgo biloba, Fish Oil, AcetylCarnitine
Fatigue-3 Phosphatidylserine, Vitamin C, Tyrosine, Fish Oil, AcetylCarnitine
Depression-3 Zinc, Chromium, Vitamin C, Tyrosine, Inositol, Ginkgo biloba, Fish Oil
Blood Glucose-3 Zinc, Inositol, AcetylCarnitine
Inflammation-3 Phosphatidylserine, Vitamin C, Melatonin, Fish Oil, AcetylCarnitine
Stress-4 Phosphatidylserine, Tyrosine, Ginkgo biloba, Fish Oil



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