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Alzheimer’s Disease Stack

General Health 4,516 SupplementDoctor
Alzheimer disease is a progressive disease of the brain that causes impairment of memory and dementia manifested b confusion, visual- spatial disorientation, impairment of language function progressing from anomia to fluent aphasia, inability to calculate and detorioration of judgement. There are six pillars of brain healthy lifestyle and that includes regular exercise, healthy diet, mental stimulation, quality sleep, mental stimulation and active social life. According to research or other evidence, the following self-care steps may be helpful.

179 Potential Effects from this Stack

Effect OnScaleContributors
Memory5 Phosphatidylserine, Fish Oil, Bacopa monnieri, Vitamin E, Melatonin, Ginkgo biloba
Cognition3 Phosphatidylserine, Bacopa monnieri, Ginkgo biloba, AcetylCarnitine
Blood Flow2 Fish Oil, Vitamin E, Ginkgo biloba
Attention2 Phosphatidylserine, Fish Oil, Bacopa monnieri, Melatonin, Ginkgo biloba, AcetylCarnitine
Sleep Quality2 Melatonin, Ginkgo biloba
Insulin Sensitivity2 Fish Oil, Vitamin E, Melatonin, AcetylCarnitine
Anaerobic Exercise2 Phosphatidylserine, AcetylCarnitine
Interferon Gamma1 Vitamin E
Prostate Cancer Risk1 Vitamin E
Euphoric1 Vitamin E, Ginkgo biloba
Photoprotection1 Fish Oil
Leptin1 Fish Oil, Melatonin
Lipid Peroxidation1 Fish Oil, Vitamin E, AcetylCarnitine
Dysmenorrhea1 Vitamin E
Infant Birth Weight1 Fish Oil
Growth Hormone1 Melatonin
Sperm Quality1 AcetylCarnitine
Treatment of Hepatic Encephalopathy1 AcetylCarnitine
Muscle Carnitine Content1 AcetylCarnitine
Ocular Blood Flow1 Ginkgo biloba
Calmness1 Ginkgo biloba
Gastrin1 Melatonin
Lean Mass1 Fish Oil, AcetylCarnitine
Plasma Melatonin1 Melatonin
Interleukin 41 Vitamin E
Immunity (aka Immune system)1 Vitamin E
Working Memory1 Phosphatidylserine, Ginkgo biloba
Endothelial Function1 Fish Oil
Cell Adhesion Factors (aka sCAM-11 Fish Oil, Vitamin E
Serum T4Neutral Vitamin E
Apolipoprotein BNeutral Fish Oil
Verbal FluencyNeutral Vitamin E, Ginkgo biloba
White Blood Cell CountNeutral Vitamin E
Red Blood Cell CountNeutral Vitamin E
Total CholesterolNeutral Vitamin E, AcetylCarnitine
TriglyceridesNeutral Vitamin E, AcetylCarnitine
Insulin SecretionNeutral Fish Oil
Serum T3Neutral Vitamin E
Risk of StrokeNeutral Vitamin E
Stroke Recovery RateNeutral Ginkgo biloba
Aerobic ExerciseNeutral AcetylCarnitine
Fat OxidationNeutral AcetylCarnitine
Power OutputNeutral AcetylCarnitine
LibidoNeutral Ginkgo biloba
Intraocular Pressure (aka IOP)Neutral Ginkgo biloba
LDL-CNeutral Vitamin E, AcetylCarnitine
Bleeding TimeNeutral Vitamin E
AdrenalineNeutral Melatonin
Free TestosteroneNeutral Phosphatidylserine, Fish Oil, Vitamin E, AcetylCarnitine
Breast Cancer RiskNeutral Vitamin E
Colon cancer riskNeutral Vitamin E
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Dosage Compound Form Frequency Dates Notes
0.00 ,,,,,,
Some researchers feel Alzheimer's disease may be related to vitamin B12 deficiency.
0.00 ,,,,,,
In case reports, three patients with Alzheimer's disease showed improvements in symptoms such as irritability, agitation, anxiety, and apathy after supplementing with turmeric.
0.00 ,,,,,,
There is some evidence that cow-derived PS (phosphatidylserine) has been shown to improve mental function and feelings of well-being in people with Alzheimer's disease, though most research has not found benefit.
10 mg ,,,,,,
10 mg per day. A small, preliminary trial showed that oral NADH improved mental function in people with Alzheimer's disease.
0.00 ,,,,,,
Some researchers feel Alzheimer's disease may be related to folic acid deficiency.
0.00 ,,,,,,
Fish oil may help slow the rate of cognitive decline in people with very mild impairment.
0.00 ,,,,,,
DMAE (2-dimethylaminoethanol) may increase levels of a brain neurotransmitter, which may foster positive behavior changes in people with dementia.
0.00 ,,,,,,
People with Alzheimer's disease may have low DHEA (dehydroepiandrosterone) levels, and supplementation may improve mental performance.
0.00 ,,,,,,
Animal studies have found the Ayurvedic herb bacopa has constituents that enhance several aspects of mental function and learning ability.
4.5 g ,,,,,,
4.5 grams per day for 12 weeks. A preliminary trial suggests that taking Panax ginseng may significantly improve a measure of cognitive function in the short term, though long-term use has not been established.
2000 iu ,,,,,,
2,000 IU daily. Antioxidant supplements such as vitamin E have been associated with lower risk of Alzheimer's disease and improved brain function in middle-aged and older adults.
3 g ,,,,,,
3 grams daily. Supplementing with vitamin B1 might slow Alzheimer's disease progression in people whose vitamin B1 dependent enzymes have low activity.
60 ,,,,,,
60 drops daily of a 1:1 tincture. Sage appears to have an effect on acetylcholine, one of the chemical messengers (neurotransmitters) in the brain and supplementing with sage has resulted in a significant improvement in cognitive function.
0.00 ,,,,,,
Lesser periwinkle contains the alkaloid vincamine, which has shown some benefit to people with Alzheimer's disease.
0.00 ,,,,,,
In a double-blind trial, supplementation with melatonin significantly improved cognitive function and sleep quality, compared with a placebo, in patients with Alzheimer's disease.
60 mcg ,,,,,,
60 drops per day of a 1:1 herbal tincture, standardized to contain at least 500 mcg per ml of citral. Supplementing with an herbal extract of lemon balm (Melissa officinalis) has been shown to improve cognitive function and reduce agitation in people with Alzheimers disease.
200 mcg ,,,,,,
200 mcg of huperzine A twice per day. Huperzine A, a substance found in the Chinese medicinal herb huperzia (Huperzia serrata), has been shown to improve memory and mental and behavioral function in people with dementia, including Alzheimer's disease.
120 mg ,,,,,,
120 to 240 mg of a standardized herbal extract daily. Ginkgo biloba extract is an approved treatment for early-stage Alzheimer's disease in Europe. It is thought to improve memory and quality of life and slow early disease progression.
1 g ,,,,,,
1 gram taken three times per day. Short-term studies have found that people with Alzheimer's disease who supplement with acetyl-L-carnitine experience improved memory, enhanced overall performance, and delayed disease progression.

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Alzheimer’s Disease Stack

Potential Interactions
Some evidence suggests that adding vitamin E to fish oil may prevent fish oil-induced increase in blood sugar levels.
  • Luostarinen R, Wallin R, Wibell L, et al. Vitamin E supplementation counteracts the fish oil-induced increase of blood glucose in humans. Nutr Res 1995; 15:953-68.

Supplementing with folic acid in amounts as little as 300 to 800 mcg per day may increase vitamin B12 requirements. Therefore, it would be prudent for people taking folic acid to supplement with vitamin B12.

Supplementation with vitamin B12, even in relatively small amounts, can increase folic acid requirements, For that reason, people taking vitamin B12 supplements should also consider taking folic acid.

In addition, supplementing with folic acid can mask the laboratory diagnosis of vitamin B12 deficiency. Failure to identify and treat vitamin B12 deficiency in a timely manner can lead to permanent neurological damage. The relatively small amount of vitamin B12 present in most supplements is not sufficient to prevent or correct vitamin B12 deficiency in people who have pernicious anemia (a condition caused by vitamin B12 malabsorption). For that reason, people should tell their doctor if they are taking folic acid supplements, so that the doctor will order alternative laboratory tests if vitamin B12 deficiency is suspected.

  • Smith AD. Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12. Am J Clin Nutr 2007;85:3-5.
  • Steiner I,Melamed E. Folic acid and the nervous system. Neurology. 1983 Dec;33(12):1634

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