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The Correct Modafinil Dose – 100mg, 200mg or 400mg Per Day?

modafinil dosageModafinil is a popular wakefulness promoting agent used by millions of patients everyday, though it started as a drug for narcolepsy, over time (reluctantly, see: Jet Lag syndrome) the FDA has allowed Cephalon to market it for other symptoms as well. It is a popular medication now used off-label to manage ADHD, aid in Weight loss and taken as  smart drug to boost mental capacity temporarily. The advantages of Modafinil are appealing and not easy to resist for those with the above aforementioned symptoms or goals.

When an individual decides to take Modafinil, they should first do their part and understand the procedure of how to carefully consume the drug. An important question one should ask before taking Modafinil for the first time is what’s the right dosage to avoid the side effects, 50mg, 100mg, 200mg, 400mg?

Modafinil’s Story

Modafinil was first developed at Lafon Laboratories in France in the late 1980’s. Modafinil was discovered after the invention of a chain of other chemicals categorized as Benzhydryl Sulfinyl. Most importantly, these included Modafinil’s precursor compound Adrafinil. Adrafinil was first found to improve wakefulness & alertness, later it was offered to treat people suffering from Narcolepsy in 1986 in France.

Modafinil was discovered as primary Metabolite and active component for Adrafinil. It was observed that Modafinil had lesser side effects & greater potency than its precursor. Although the use of Modafinil has grown exponentially in countries like UK and US, Adrafinil is used as a substitute to Modafinil as the drug is available without a prescription. Modafinil has been sold in United states from 1998, under the name Provigil, which is distributed by Cephalon Inc (The parent company of Lafon from 2001).

FDA, Modafinil & Dosage for ADHD

The FDA (Food and Drug Administration) has approved Provigil for treating shift work sleep disorder, narcolepsy and for hypopnea (Obstructive sleep apnea). Although some other medical conditions were found to benefit from Modafinil, FDA has failed to identify any additional benefits, even til this day.

Many studies were conducted and demonstrated how Modafinil can be used in treating ADHD in children and adults while carrying very few side effects, addiction, withdrawal or abuse when compared with similar drugs like Adderall or Ritalin. There were negative reactions in children aged 7 to 12 in about 20 of 100 patients, and for this reason the FDA Advisory committee in a vote of 12 to 1 decided that Cephalon would not be allowed to create the drug Sparlon (Modafinil in 345mg to 420mg doses) which was to be used for ADHD in children — which also happens to be the dose that Cephalon considered to be the “effective” dose in treating ADHD.

Off-Label and Recreational Modafinil Use

modafinil dose guideModafinil’s off-label use accounts for 90% of it’s sales (2004). Additional conditions that the drug Modafinil has been used include psychiatric and neurodegenerative disorders. This could also include treatment for Schizophrenia, Parkinson’s disease, bi-polar disorder, depression, medicine-influenced Fatigue or disease-related. ¹

Modafinil was discovered to produce a stabilized effect on mood, creating positive thoughts, well-being and elevated confidence. Modafinil can also help control the stress and can help reduce the symptoms of anxiety.

In the US, Provigil is also being used in treating atypical depression. This medical condition is noticeable in over-eating, hypersomnia, rejection sensitivity and low energy. Although as these are all off-label use cases, studies need to be performed so the FDA approve the use and dose required for treating such symptoms and conditions.

A good number of patients have found success taking Modafinil as a treatment for weight loss. Modafinil can result in advanced caloric expenditure and it can reduce the appetite by almost 38% less calories per day. Despite being used for many off-label purposes, it’s primary use continues to be that of a temporary cognitive enhancing agent.

A single dosage of Modafinil in the morning can give individuals a very sharp focus and eliminate urges for procrastination. To counter the effects of fatigue, the US Air Force has approved Modafinil to be used to increase alertness in personnel. Infact the late-founder of the company himself stated that Modafinil can be used as a alternative to coffee or amphetamine like substances when asked, “What else can this novel molecule be used for?” the CEO said.

Modafinil Dosage

provigil 50mg
Sample size of 31 patients consuming Provigil showed that 200mg followed by 50mg are the most common dose’s. Patients decided to go against mentioning if they had any condition, symptoms they were taking it for and it’s perceived effectiveness. We will be releasing a graph that will let us know the intent based on type of stack made, based on manually checking the stacks, most are for “Cognitive Enhancement”.

What dosage is right for you? Modafinil usually comes in two sizes, 100 mg and 200 mg. It’s the sales of 200mg out rank that of 100mg. For the most part your doctor will prescribe you the right dosage based on any medical conditions you may or may not have. Generally, if being taken for mental alertness, 25mg is a good starting point to determine if the desired effect is felt, if not you can increase your dose the day after. It should not matter if you are taking it on empty stomach or not. One easy way to tell if you have taken too much is a headache.

modafinil half life doseThe usual recommended dosage of Modafinil is 200mg, that is once in day often in the morning, some people claim it takes up to 3 hours to “kick in” (see graph below) and thus it may be advisable to take right upon waking as you will feel alert by the time you get to work.

The Best Modafinil Dose for You

First things first,  Modafinil is not for children, Children shouldn’t take it at all — especially given the disapproval by the FDA based on testing.

If you take Modafinil to counter shift work sleep disorder (Excessive drowsiness as a result of irregular work hours or schedule) then you should consider taking Modafinil just one to three hour right before the shift begins. Thus if you’re working for 8 hours, and even if the drug takes 2 hours to come into effect, based on the graph on the left you can see that the concentration in your blood remains high enough for you to get through your work effectively.

Some believe that Modafinil needs to be taken as per the body weight; however, only little evidence was there to prove that Modafinil is necessary only for an average user. Every supplement or drug has it’s pros and cons, a risk-reward ratio, and Modafinil is no different. Although Modafinil is considered to be a safe drug to take, few possible side effects may be associated when taken. Side effects such as nausea, nervousness, headaches, insomnia, dizziness, anxiety, back pain, rhinitis and diarrhea.

In placebo controlled studies, 8% of the individuals had to discontinue the drug due to adverse side effects. The most commonly noted side effect was headache. Patients on our site have noted that lowering the dosage and then taking it over 2 sessions reduced or removed headaches.  Please consult your doctor or a healthcare professional if any side effects do come up. When you have decided to take the drug start with small dose and observe for a week . If there are no negative effects you could increase the dosage. You can also learn more about Modafinils successor, Armodafinil, or Nuvigil here.


What Does Modafinil Cost? Non-Generic vs. Generic

modafinil costModafinil may be bought under the brand name Alertec in Canada, Provigil in the United Kingdom and United States, and Modvigil in Australia. It is one of the most well-known smart drugs used by individuals for its functions to not only improve cognitive function but also as a motivation enhancer and a “fatigue-buster”.

Many studies are available to prove Modafinil’s effectiveness. However, despite of its effectiveness and numerous benefits it provides for off-label use, Modafinil is not widely used. Each individual pill may cost as high as 50 dollars USD without insurance for 200mg pills.

What is the retail price of Modafinil?

Since the late 1990s, Modafinil has been patented by the French pharmaceutical giant named Cephalon, formerly known as Lafon. Because of the lack of generic alternatives, the cost of Modafinil has been kept high and is one of the most expensive drugs available in the market today. When the patent of Cephalon was about to expire, the court was used effectively by the company to stop the production of generic Modafinil for another 4 years. Nowadays many brands are available but generally the price remained high, although there are cheaper alternatives as the market continues to mature.

How much does Provigil Cost?

In the United States, Provigil is known as the non-generic form of Modafinil. Medical professionals themselves believe that the cost of Provigil may be too expensive for most people, regardless of if they are covered by insurance or not. Since the availability of generic brands of Modafinil, many health experts continue to provide the original branded version or the newer form of Modafinil known as Armodafinil, thus the cost for people with genuine conditions such as narcolepsy continue paying the high cost associated with their condition. If your healthcare provider prescribes you branded Modafinil, it is in your discretion to request the generic form of the medication.

The cost of Modafinil depends on the seller; prices vary greatly from one pharmacy to the other. For individuals who are on a tight budget, contacting different pharmacies for the best price will be very beneficial.

Listed below are the prices for Provigil at 5 national pharmacies of the United States as of October 2013:

  • Rite Aid: 100 mg: $826.19; 200 mg: $1,223.99
  • Costco: 100 mg: $879.00; 200 mg: $1,264.14
  • CVS: 100 mg: $867.99; 200 mg: $1,299.99
  • Walgreens: 100 mg: $971.99; 200 mg: $1,338.09
  • WalMart: 100 mg: $987.46; 200 mg: $1,490.84

Based on the above prices, the best way for you to save is to buy the 200mg tablets and then administer them in two equal halves to make 100 mg pills at a price that is 25 percent lower. In the United States, insurance companies will not pay the cost of a non-generic medication, and you may need to pay a high deductable from your own pocket until insurance coverage sets in.

How much does Generic Modafinil cost?

Even though the Provigil formula was not released, the primary ingredient is Modafinil and as long as you administer the same dosage, you would still achieve the same effects. The generic drug will always be called Modafinil and it should be available at drug stores that carry the brand name drug.

  • Rite Aid: 100 mg: $543.99; 200 mg: $850.84
  • Costco: 100 mg: $374.00; 200 mg: $469.23
  • CVS: 100 mg: $549.99; 200 mg: $829.99
  • Walgreens: 100 mg: $589.99; 200 mg: $880.09
  • WalMart: 100 mg: $553.32; 200 mg: $799.62

The Rite Aid costs that are written here incorporate their “membership” reserve funds and you need to present their membership card to get the rate. Costco offers a fair rate and by no means is it the best rate, you save approximately $150 to $200 for 30 pills per month, not a small amount but not less than the other stores. Of course this too takes into account that you have a Costco membership.

Another alternative is to buy Modafinil from online drug stores based outside the US. A starting point for Modafinil online is Indian pharmacies, where you can purchase 200mg Modafinil pills for as low as $2 each. Notwithstanding, this is an unsafe recommendation as there are less quality controls set up and you are taking a chance when ordering from fly-by-night operations.

Another thing to worry about is that the US Customs will defer or grab your shipment if they realize your package has controlled substances, especially if it is coming from a foreign country. Additionally, if you are located in certain Nordic countries or Canada, you can be sure you will not get your shipment because of customs being much more strict. Sometimes you may just need to prove that you were prescribed the drug you are ordering and in that case you may request the online pharmacy to provide it, but this too is harder than it sounds as most won’t provide any documentation. This is why we point people to alternatives, see Modafinil vs Adrafinil.

Is it possible to get Modafinil without a prescription?

generic modafinil costModafinil is a prescription medication and is not accessible, lawfully, without a prescription especially if you reside in a Western country. There is a non-prescription precursor as mentioned above called Adrafinil which may be your best bet. Adrafinil is sold online in both pill form and powder form which is much cheaper. As a precursor, Adrafinil is metabolized in the liver before turning into Modafinil.

Adrafinil cost comes to under fifty-cents per dosage. This makes it a great deal less costly than Modafinil, however a higher dose is needed to get the same results.  Adrafinil is a feasible non-prescription alternative to Modafinil and since it must be converted by the liver, persistent use can harm or irritate the liver. This danger is like if you somehow managed to utilize an excess of Ibuprofen or Tylenol. Adrafinil thus should not be used for long stretches but “cycled” and used when really needed, additionally you may add milk thistle to your stack to try to keep your liver enzymes at healthy levels.

In Summary…

Modafinil can be costly if buying in branded forms, unless one has insurance that will cover it. Generic Modafinil too can be pretty expensive, based on the prices listed above. It is wise to get in touch with your insurance provider to figure out if they offer some sort of pricing plan for the brand name Provigil or for generic Modafinil. The two other alternatives that really exist for someone that can’t afford either is buying it online and taking a risk with the quality, not having it shipped at all, or it being seized at customs.

In which case ordering the alternative Adrafinil from within the United States would be your best bet. Please keep in mind, we are not endorsing circumventing any law that is put in place to keep you safe, we are merely pointing out the obvious, that alternatives exist, and if you do need it and have been diagnosed with a condition that requires it, there may be a way! Stay safe and always consult with a professional.

Guide to Provigil Abuse, Addiction and Withdrawal

Modafinil Provigil

Disclaimer: The below article is a guestpost by Ash Sharman (A nootropic enthusiast, who has submitted a few more articles to be posted on the topics of nootropics to us) and thus are not the views of Track My Stack.

Provigil, popularly known by its generic name Modafinil, is a smart drug used for enhancing mental performance, reasoning and learning. It is used for improving wakefulness in adults. Many adults experience excessive sleepiness because of sleep apnea, shift work sleep disorder or narcolepsy.

Researchers are not sure how Modafinil promotes wakefulness. One hypothesis is that it may increase dopamine levels in the brain by obstructing the reuptake of dopamine, a neurotransmitter that regulates the chemical signals from one nerve cell to another. The Food and Drug Administration (FDA) approved this drug for the cure of narcolepsy in 1998. It also approved its use for shift work sleep disorder and obstructive sleep apnea in 2003.

Top Reasons for taking Provigil/Modafinil as a smart drug:

Provigil has been portrayed as a magic pill. When consumed, it makes a person feel more eloquent and better equipped to perform complex and demanding mental tasks. It is popularly used in college campuses and high-stress profession that requires focus and attention to details. This is why it is common to find it on Wallstreet (in Finance) or in a developer’s (Programmers) medicine cabinet. You will enjoy hours of unshakable concentration for up to 15 hours after taking a single dose of up to 200mg. However, it is no adderall, it will keep you from feeling tired/sleepy/groggy which will allow you to keep focused. As the “fame and excitement” of this smart wonder drug is on the rise, fears about its abuse, addiction and withdraw dangers also takes the central stage.

Some call Provigil a “Super Drug” as sometimes it is used for performance enhancement by military fighter pilots and soldiers during combat situations. It also enhances short-term memory allowing the users to remain awake for longer periods.

What are the key things you need to know about Provigil?

Provigil is a federally controlled drug and should be used as per the direction of a GP. You should store it in a safe place to prevent abuse or misuse. It is against the law to sell this drug to another person. The drug is not approved for use in children for any medical condition. And, it is still unknown whether it’s safe or works for children under the age of 17 or not. Individuals that show signs of sleep apnea use this drug in combination with other medical treatments.

Provigil can lead to grave side effects including a serious rash or an allergic reaction affecting your liver and blood cells. The side effects are life-threatening and require medical treatment. You must stop taking the drug immediately and seek medical help if you develop a skin rash, blisters, rashes, yellowing of the skin, dark urine or have trouble swallowing or breathing.

Basic dosages for Provigil

Provigil comes in two strengths, 100 mg and 200mg. It is generally taken during morning hours to prevent daytime sleepiness or one hour before the start of a work shift. If you consume too much Provigil, you will experience nausea, diarrhea, confusion and (obviously) have trouble sleeping.

Consequences of Provigil withdrawal

People who have used Provigil for the long term and stopped did not show any physical withdrawal issues.  It is assumed Provigil gets its effect by releasing CNS histamines in the brain. These agents create targeted stimulation of neurotransmitters which causes Provigil’s effects of wakefulness and alertness. You may experience a headache with Provigil/Modafinil use which may require you to consume a lot more fluid/or food as your appetite may get suppressed without you noticing it. It could also be because your dose may be too high to start and other users have said choline/uridine MAY help. Everyone’s biology is different, stop use if the headaches don’t subside.

Ways to avoid Provigil abuse, addiction and withdrawal dangers

If you fear of any Provigil abuse, or have any history of substance abuse, it is good to take some other natural nootropics that present less issues. Keep in mind, Modafinil isn’t necessarily addictive per say. If you do start taking Modafinil consider using our platform as a medication tracker tool to make sure you have no negative interactions, your dosing correctly and to get general feedback from our users.

It is important to be little careful while using Provigil as some of its side effects can be very serious (even though they affect a very very small percentage of the population). It should not be used without prior consultation of doctor in any case if possible. Feel free to also browse around our site and explore stacks for nootropics to see what others are taking.