Skip to main content

Top 10 Most Effective Nootropic Supplements

nootropic supplementsWhat are the most effective nootropics that you can try? Nootropic supplements are also known as brain boosters and cognitive enhancers because of their ability to enhance mental performance and produce various positive effects to the brain. This includes improved speed of recall, heightened mental energy, improved short-term and long-term memory, enhanced mental clarity, and improved concentration.

These supplements may also improve the communication between neurons, thus enhancing their overall effectiveness and could promote a much healthier brain. This leads to better executive function, enhanced fluid intelligence, even more creative thought, and improved problem-solving. This means not all nootropics are taken “when you need a boost” but can be taken as a “vitamin” for neuroprotective reasons as well, think about it, if you can take a supplement for your body, why not to a larger extent for your brain as well.

There are a lot of clinical cases where some of these nootropics have helped and they include: attention deficit hyperactivity disorder (or ADHD), Parkinson’s disease, dementia, Alzheimer’s disease, as well as age specific cognitive decline. These benefits are the reason nootropics are being widely used by many people, for some, many times throughout the day. Below we list our top 10 supplements (& drugs) that may be of use to you. CONSULT YOUR HEALTH CARE PROVIDER BEFORE STARTING A REGIMEN WITH THESE. Consider this article a guide for beginners to get know about what’s out there and what their functions are.

There are many types of supplements available and this may be overwhelming for those looking to start. We wanted to make it easier by listing the top nootropic supplements in order of  most potent and most effective nootropics to “least” in our top 10. Least is in quotes because different supplements provide different benefits and have different side effects. By no means is this list comprehensive.

Modafinil

What is it? Modafinil is a smart drug that enhances energy levels and alertness – particularly in individuals who do not usually get enough sleep. User reports suggest that it gives them the desired mental energy boost that they need better than caffeine and other stimulants do. Hence, it has gotten to be well known for off-label use as a focus enhancer. Modafinil is clinically prescribed for individuals who suffer from sleep disorders such as obstructive sleep apnea, narcolepsy, among other sleep related conditions.

What are the benefits of Modafinil?

Modafinil has appeared to help individuals stay alert and focused, and additionally clear their mind, if they lack sleep or are sleepy. Researchers have effectively demonstrated a relationship between the utilization of this medication and retaining intellectual capacity in a sound state against variables such as absence of sleep. Be that as it may, not every one of them could associate Modafinil to a change in psychomotor capacity in human test subjects.

Regardless of its beneficial outcomes on concentration enhancement, focus and short-term memory, it hasn’t demonstrated huge enhancements in cases that concerned healthy adults with attention deficit hyperactivity disorder (or ADHD). Then again, the same condition found in kids appeared to benefit from the utilization of Modafinil to the same or more prominent degree as methylphenidate, the prescribed medication of choice for that purpose.

Noopept

What is it?

Noopept is primarily used to enhance learning capacity, memory, and concentration. It is known to be one of the more potent cognitive enhancers and considered to be much more effective than most other synthetic nootropics especially when compared to other racetams.

What are the benefits of Noopept?

This supplement provides numerous benefits related to the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. It is thought that these combined actions are the reason for the wide range of cognitive benefits.

The most well-known benefit of this drug is it’s ability to significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, better mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and logic processing.

Adrafinil

What is it?

Adrafinil is a drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. While as Modafinil is a controlled substance, Adrafinil is not, it metabolizes in the liver to form Modafinil. It can be a bit harsh on the liver for this very reason, so it is not advised to supplement this drug frequently and if done so, your liver enzyme levels should be monitored closely.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.

Pramiracetam

What is it?

Pramiracetam is an “advanced version” of Piracetam, it’s mechanisms of action too is very similar, it includes binding to Acetylcholine receptor sites in the brain and inhibiting their desensitization in order to increase the action potential of the neurons. Pramiracetam is one of the most powerful Nootropic supplements available. It has a very high bioavailability and is a fat soluble racetam and is noted to have long half-life.

What are the benefits of Pramiracetam?

Pramiracetam is known to be one of the “purer” Nootropics. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

Phenylpiracetam

What is it?

Like pramiracetam, phenylpiracetam is also an “advanced and stronger” version of Piracetam. It contains a Phenyl molecule group attached to the original Piracetam and is known to be 60x more concentrated. This is why Phenylpiracetam provides better benefits may be a considered a step up from Piracetam.

What are the benefits of Phenylpiracetam?

Phenylpiracetam is known by its ability to help improve general tolerance to stress and cold. According to its user reviews, Phenylpiracetam could increase a person’s memory, focus, learning capacity, concentration, attention span, as well as mental energy. Additionally, it helps enhance physical performance, promotes intense focus, and improve workout recovery times.

Sulbutiamine

effective nootropic supplementsWhat is it?

Sulbutiamine was originally synthesized in Japan, it is a synthetic version of Thiamine (or Vitamin B1) and is primarily used to enhance the overall energy levels of the brain. Sulbutiamine is not really considered a “true” Nootropic; however, it seems to go very well with other supplements that is why it is commonly stacked as part of a larger nootropic regimen.

What are the benefits of Sulbutiamine?

Sulbutiamine helps a person relax and promotes a feeling of general well-being. It improves the ability to concentrate and focus as well as enhancing attention span.

Aniracetam

What is it?

Aniracetam belongs to the Ampakine family and is considered as a Racetam. It has the ability to provide mood boosting effects and reduces the levels of anxiety and stress and thus it is known as a potent anxiolytic. Aniracetam could greatly benefit those who suffer from depression, social anxiety, and other mood disorders.

What are the benefits of Aniracetam?

Some of the benefits of Aniracetam include improving focus, memory, and attention span. Aniracetam is not considered a CNS stimulant. However as a user it’s common to experience a initial boost of energy followed by feelings of relaxation. It is said this nootropic also increases memory Input and Output (I/O reference: Dave Asprey), meaning it helps with recall and speech fluency, however consider this anecdotal.

Huperzine A

What is it and what are its benefits?

Huperzine A is a herbal nootropic that is widely used by people for it’s ability to help inhibit an enzyme that degrades the learning neurotransmitter, acetylcholine. It is derived from a plant called Huperzia Serrata, which is abundant in China. Acetylcholine is one of the most important neurotransmitters in our body as it helps improve numerous cognitive functions and processes and enhances memory.

5-HTP

What is it and how does it work?

5-HTP is a chemical that is synthesized in the human body via L-Tryptophan and is converted into Serotonin inside the brain. Like acetylcholine, serotonin is also among the most important neurotransmitters since it is also responsible in promoting normal sleep patterns and regulates mood. It could also prevent over excitation of the brain and helps with better focus.

Choline

What is it?

Choline is a substance that can be found in small amounts in various types of food products that we consume every day. It is one of the basic components for any nootropic/cognitive enhancement supplement stack. Choline sources such as Choline Bitartrate, or CDP Choline function as a direct precursor for the production of Acetylcholine, thus it is important to supplement or consume it via food to make sure you have adequate levels.

What are the benefits of Choline?

Some studies show that choline could better potentiate the effectiveness of various nootropic drugs. Headache are considered to be a common side effect following the intake of racetams, a depletion of choline could be the culprit. Although it really does depends on your own biology, as it could be many other factors. Many will have you believe that you must supplement choline with any racetam and that is simply not the case. It should be consumed “as needed”, a little trial and error will you determine the right dose, but stay within the suggested dose on the label.

Based on TrackMyStack Users

Our users are taking the following nootropic supplements for cognitive enhancement, this report is updated live and can be accessed here to view the live version.
nootropic supplement report

Gender breakdown of the above report:

nootropic report by gender

 

References:

  1. http://www.drugs.com/cdi/modafinil.html
  2. https://en.wikipedia.org/wiki/Adrafinil
  3. https://en.wikipedia.org/wiki/Phenylpiracetam
  4. https://examine.com/supplements/sulbutiamine/
  5. https://www.smartdrugsforthought.com/what-is-aniracetam/
  6. http://www.webmd.com/vitamins-supplements/ingredientmono-764-huperzine%20a.aspx?activeingredientid=764&activeingredientname=huperzine%20a
  7. http://www.everydayhealth.com/drugs/5-htp-5-hydroxytryptophan
  8. http://www.webmd.com/vitamins-supplements/ingredientmono-436-choline.aspx?activeingredientid=436&

Natural Cognitive Enhancers

Top Natural Cognitive Enhancers You Need To Try

There are many cognitive enhancers in the market, however it is understandable that for many new people it may not make immediate sense to start off with synthetic chemicals as the effects may be too strong and just not needed, below we will discuss 5 nootropics or 5 natural cognitive enhancers for memory, energy and alertness with the least amount of side effects and maximum benefits.

All the cognitive enhancers below can be referred to as nootropics, cognitive enhancers supply the brain with a high level of neurotransmitters support or cause neurogenesis. It is advisable to know that these cognitive enhancers, as they are natural, take time to come into effect, they are not isolated chemicals that you would get from a lab based supplement. Some of these supplements have been used for literally thousands of years for cognitive enhancement purposes, as is the case of Bacopa in Ayurvedic Medicine.

We are going to skip some of the “mainstream” cognitive enhancement products that you may have already heard about such as: Caffeine, and Ginkgo Biloba. Without further ado, our list of top natural cognitive enhancer reviews below, in descending order of importance to us:

5. Pycnogenol ™ or Pine Bark Extract for Cognition

pycnogenol
Read Full Review

It does many things aside from being a natural brain enhancing supplement, such as: helping manage blood sugar levels, helps with skin tone, supports blood vessel health and even boosts heart health. The supplement is derived from the French maritime pine bark, if taken for cognition, look for an improvement in focus, memory and executive function capabilities. A study done in Italy showed that it provided significant improvement in mood, memory, attention span, decision making, which makes it great for those that have ADHD or those looking to improve their attention span. Information referenced from:
“Pycnogenol improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55.” From: The Journal of Neurosurgical Sciences 2014, 58 (4): 239 – 248

4. Lion’s Mane Mushroom or Hericium Erinaceus

It is a edible medicinal mushroom found in Asia. The compounds C-H and lions-mane-mushroom-for-bnfA-I isolated promote NGF (nerve growth factor). People say it is a good treatment for and prevention of dementia. Results suggest the possibility that H. erinaceus is absorbed into the blood and delivered directly to your CNS. Other potential benefits: immune-enhancing properties, hypoglycemic effects and antioxidant activity.

Read Review
Buy Here

3. Nicotine

nicotine cognitive enhancement choline
Read More

Grab a pack of cigarettes, just joking. Although this goes against most people’s immediate sense, hear us out. There are nicotine receptors in your brain, and when entertained, you get more focused and alert. Ever see anyone taking “smoke breaks” to clear their mind so they can come back and focus again…? There is some science to this, however, many people also sip on a coffee when doing this, nicotine negates the effects of coffee, so you should do one or the other. If you have an addictive personality or are an ex-smoker, this is a obvious no-no, but many professors and scientists (not your MD) systematically recommend nicotine (gum, vaporizer or patch) over sipping on coffee for say staying up at night when you need to drive, or need mental clarity and energy.

Don’t believe us? Here is the science! Take a look at any of the following references:
www.scientificamerican.com/article/will-a-nicotine-patch-make-you-smarter-excerpt/
www.ncbi.nlm.nih.gov/pubmed/1579636

2. MCT Oil

brain octane
Buy This

More specifically Brain Octane Oil, which we have written about many times. The brand we use is BulletProof, you are more than welcome to try any brand you like. Brain Octane just happens to be refined 18X, providing more direct ketone based energy for your brain than MCT Oil, which too is more refined than regular Coconut oil. Your brain loves to use “Fat” or “ketones” for energy rather than carbohydrates. It takes more energy to convert carbs to energy than fat. This should be supplemented 15 minutes before studying, put it in your coffee or just have a teaspoon of it, and your brain will have premium fuel to keep going for up to 2 hours. Have we mentioned Butter coffee? This is natural, healthy, and something you will enjoy, a real tri-fecta win. These guys have come out with brain octane tablet’s which are perfect to travel with as well if you want to check that out. They also have a new product called “Instamix” which has grass-fed butter + brain octane premixed, it act’s as a ‘creamer’ but is healthy. Read More about Brain Octane here.

Bacopa Monnieri (Waterhyssop)

bacopa for brain
Read Full Review

Well known as a cognitive enhancing plant — Bhrami in Ayurvedic medicine, it is to be taken at 750mg every night (could possibly need to take up to 3 pills) with a fat source. It is very important that this is a quality product, look for 50% bacognize, which contains a standardized amount of bacosides A and B). The obvious benefits include enhancing the brain with it’s own antioxidant enzymes. It may help with memory, anxiety, mental fatigue and visual processing. Make sure you supplement this for 4 weeks before deciding that it doesn’t work, and even when it does, it is not like caffeine whereas you “just feel it” it will come in the form of being able to remember things that you would not have been able to otherwise.

 

Lumonol Review

Bonus: Lumonol

Although this supplement isn’t a 100% natural, we feel like aside from Noopept it does encompass many natural cognitive enhancing ingredients that work exceptionally well together. Instead of taking one supplement at a time, you could yield the power of all of them in 1 go. It is highly rated by users of TrackMyStack.

 

 

 

Hopefully our reviews of natural cognitive enhancers is a good starting point for you to delve into optimizing your memory. You may learn more about each supplement in detail by clicking on the image to it’s left, and may additionally buy it as well if you feel like it is right for you. These are not as ‘mainstream’ but still very well researched plants, as you will come to see for a good reason as well. This is just our list of what we consider the best, your results may vary, and what better place to track it’s efficacy than TrackMyStack.com.

Final note …
“Natural brain enhancement” is possible it just may take more time to “build up” in your system and may provide additional benefits than just cognitive benefits as noted above. Share your results via a health journal on our site or write your comments below. Good Luck.

Limitless Drug NZT-48

The Real Limitless Drugreal limitless pill

The film Limitless, which stars Bradley Cooper, Arbie Cornish, and Robert Deniro, has made a huge impact on society. This is mainly because it revolves around mental capabilities and how we could unlock our full potential just by taking a single pill- the NZT 48 drug.

What is NZT?

In the film, NZT-48 is such a powerful drug that it makes Bradley Cooper, known as Eddie Mora in the movie, unlock his full potential. He is superhuman when he takes the pill; not only is he able to use 20% of his brain’s capacity, but he is able to go much beyond that.

In  reality, we use 100% of our brain, not all the time, but we use different parts of our brain for different things, the 20% of our brain usage is a urban myth. Anyways Bradley becomes the smartest living creature, doesn’t run out of energy, is able to learn languages and make a lot of money in the stock market. Would this be something you would take?

Does NZT48 really exist? The truth is, NZT-48 is just a creation of fiction and it was created to sell the movie. So the question is, why do we have the need to talk about this topic? Does it only give us a dream, or a false hope of using our brain’s potential 100% of the time? Even though NZT-48 is not real, there’s supplements and drugs referred to as Nootropics and they are starting to appear promising.

What are Nootropics and are they close to NZT?

By definition, nootropics are drugs that can protect your brain, enhance memory and/or other cognitive functions. They serve to promote enhancement in memory and facilitation of learning (1). Among the most famous nootropics today is the Racetam family and the first nootropic drug to be used widely was Piracetam, a synthetic derivative of GABA, also known as aminobutyric acid. You don’t need to remember this, although if you were on it, it wouldn’t be hard..would it?

Although its mechanism of action is still not fully understood, studies show that Piracetam positively affects the release of neurotransmitters in our brain and their receptor-binding capabilities. This improves cell functioning and leads to cognitive enhancements such as more efficient and easier memory formation, and memory recall. Also, Piracetam is involved in the activation of Acetylcholine, an important neurotransmitter in the brain related to memory processes and development (2). It is fairly easy to buy online as well and is considered safer than table salt (when you look at the LD50).

At present, various nootropics have already been discovered; these are much more potent than the parent compound Pireacetam. These smart drugs have a wider array of cognitive benefits and improve other areas like mood, behaviour, energy, and others. One such smart drug is Noopept — it is believed to be 1000x more potent than its derivative Piracetam. Other familiar nootropics also include Phenylpiracetam– also a derivative of Piracetam and is believed to be 30-60x more potent than its parent compound Piracetam.

One notable feature is that it has a phenyl ring added to the original structure, giving it a higher affinity for Norepinephrine and Dopamine, and making it easier to cross the Blood-Brain Barrier or BBB. Moreover, it enhances physical performance and gives stimulating and energizing effects through an increase in Noradrenaline levels.

Although athletes find this very useful, it is banned in the Olympics due to its psychostimulatory and cold resistance properties. Phenylpiracetam also has the ability to motivate and reduce the effects of anxiety and stress. Finally, other various smart drugs known in the market today include Pramiracetam, Aniracetam, Alpha GPC, Citicoline, Phenibut, and many more.

Through gradual research and experiment, a lot of smart drugs today show a large resemblance to NZT-48. The above are marketed as supplements but the FDA would not classify them as supplements. There are some drugs that are approved by the FDA (in America, it is the regulatory agency, and we will talk about that below).

Is Modafinil the original limitless pill?

modafinil limitless review

Is modafinil really the original nzt48 pill? Consider Adrafinil, as the legal limitless pill and is available for sale online. Is it also a fictional drug like the NZT-48? Well here is the good news, Modafinil in contrast with NZT48, is a real-life drug. Yes you heard it right, Modafinil is not just available on our television screens, but we can actually buy it. But how is Modafinil related to the limitless pill NZT-48? Modafinil was actually the inspiration for NZT-48. It is used as a wakefulness-promoting agent primarily used to treat Narcolepsy (a condition causing excessive daytime sleepiness), shift work sleep disorder, and other sleep disorders.

Its wakefulness-promoting properties and increase in energy levels may be attributed its role as an adrenergic receptor agonist. It activates orexins/hypocretins (these are brain peptides) thus, increasing dopamine, norepinephrine and histamine levels. Moreover, Modafinil serves to improve memory and brain function through enhanced neuronal stimulation; more specifically, positive stimulation of Glutamate receptors and inhibition of Glutamate breakdown.

Because of Modafinil’s mechanism of action, it is the drug that is the closest thing to limitless pill NZT 48. Soon we will also review Donepezil which many now consider a limitless like pill as well. Modafinil is obviously a prescription drug and there can be many side effects, however with a good diet and proper nootropic supplementation you can ‘generally’ always feel noticeably smarter than your baseline, it is like body building, you can take supplements to go from your baseline to your absolute genetic potential but then as bodybuilders take steroids, drugs like modafinil can be used to push the brain to it’s capacity and thus we don’t recommend anyone try it right off the bat, especially not without consulting a physician.

Conclusion

Although NZT-48 may just be a fictional drug–the idea is real, there are a lot of promising smart drugs in the market that offer similar benefits. One supplement may provide benefits in one facet, but when stacked with others may be the complete regimen you need to feel more intelligent. We urge you to browse different stacks and see the results people are getting. A popular example of stacking is the combination of Racetams with Cholinergics.

For instance, the actions of racetams are attenuated due to an increased level of neurotransmitters that are essential for brain functioning. Be sure to track your results over time to see how the changes are affecting you. If you would like to skip nootropics and go straight to a nzt like smart drug consider buying adrafinil (modafinil precursor) here.

 

References:

  • http://www.merriam-webster.com/medical/nootropic
  • https://smartdrugsforthought.com/what-is-piracetam/

 

Alpha GPC Effects & Dosage

alpha gpc effects

Alpha GPC Review: Effects and Dosage

Alpha GPC or Alpha Glycerylphosphorylcholine which is also sometimes referred to as Choline Alfoscerate, is one of the many variations of choline supplements available today. In the last post we discussed the best sources of choline. AlphaGPC is a popular and effective source of choline and has a unique property of crossing the blood brain barrier easily, thus delivering superior results faster. It is purified from soy lecithin and is considered to be one of the best choline sources available today, read additional benefits of alpha gpc here. Additionally you can check our past write up on all the benefits of choline as well.

How does Alpha GPC work and what are its benefits?

Since Alpha GPC is water soluble and can easily cross the blood brain barrier, its results are experienced at a faster rate. But how does Alpha GPC really work inside our brain and body? Let’s get to knowhow Alpha GPC acts and what it’s benefits are to the human health.

Alpha GPC for enhanced cognition

One of the commonly sought benefit of Alpha GPC is its influence on an individual’s cognition. This may be attributed to its action on the cholinergic system. It increases the amount of available Choline, which then converts into an increased production of Acetylcholine. Acetylcholine is the neurotransmitter responsible for an individual’s memory, learning and mood. Moreover, it also has a vital role on one’s contraction of muscles, the regulation of the endocrine system, and REM or Rapid Eye Movement sleep cycles (1). Because Alpha GPC increases the levels of Acetylcholine, it may result in an enhanced cognition. This includes increased learning ability, enhanced memory formation, storage and recall, improved attention span and focus, and faster processing speed. Although Alpha GPC is a choline source, it is also considered to be a nootropic because of its cognitive-enhancing properties.

Improved Mood

Researchers have also found that aside from the Cholinergic system, Alpha GPC acts on the Dopaminergic system as well. It serves to increase Dopamine levels in the cerebellum and prefrontal cortex of the brain. Dopamine is the neurotransmitter responsible for an individual’s memory and learning capabilities, attention, pleasurable reward, behaviour and cognition, and most especially for mood and sleep (5). With an increased level of this neurotransmitter, there will be a significant improvement in one’s mood and cognitive abilities. It may also be of great help to deal efficiently with stress, anxiety, depression, and even signs of OCD or Obsessive Compulsive Disorder.

Neuroprotective property

Alpha GPC also appears to have neuroprotective properties. It serves to protect our neurons from damage and helps maintain their health. In this way, there would be an improvement in the signal transmission or communication between the neurons and in the synapses.

The neuroprotective mechanism that Alpha GPC possesses may be attributed to its role in the integrity and structure of our cell membranes. This is because the other half of the Alpha GPC molecule, the glycerophosphate, is a precursor to membrane phospholipids and also plays a role on the repair and maintenance of the brain cell’s membranes. (2)

Alpha GPC increases Growth Hormone

Individuals who wanted to have a significant step up in their cognitive functions are not the only ones inclined to the use of Alpha GPC. Athletes, weight lifters, and other active professionals, are also looking to Alpha GPC as one of their important workout components. This is because studies have shown that Alpha GPC works with our pituitary glands by stimulating the production of Human Growth Hormone or Somatropin. Human Growth Hormone is a small protein that acts on many tissues throughout our body. In children and adolescents specifically, Human Growth Hormone stimulates the growth of bone and cartilage. While in people of all ages, it plays a role in the production of protein and in the utilization of fat. It also interferes with the action of insulin, raises blood sugar levels, and raises the levels of insulin-like growth factor-1 or IGF-1. (3)

Studies have shown that supplementing with Alpha GPC can increase muscle mass while reducing the amount of body fat in healthy adults. It also increases exercise capacity and bone density as well. There would also be an improvement in our cell’s growth, reproduction and repair. (4)

Is Alpha GPC safe to use?

Alpha GPC is known to be a safe supplement and is generally well-tolerated. However, if the choline source is impure or when used beyond the recommended dosages, it may produce some Alpha GPC side effects. These are generally mild and may include headaches, nervousness, dizziness, nausea, fatigue, gastrointestinal problems, decreased appetite, and increased sweating and salivation.

If these reactions are experienced, you might want to lower your daily dosage or cycle its use. For example, you may avoid taking Alpha GPC for a few days and return back to using it.

Alpha GPC Dosage

Generally the recommended dosage of Alpha GPC falls between 300 mg to 1200 mg. The most commonly used dose however, ranges from 300 mg to 600 mg. This daily dose may be divided and taken into multiple administrations if you wanted to have a more constant and sustained release of benefits. You may also take it once a day, normally in the morning since it acts as a stimulant. When taking it into multiple administrations, it would be best not to take Alpha GPC later than midday since it can interfere with your ability to sleep at night.

Knowing the right amount of Alpha GPC you need and when to take it would greatly be a factor in achieving the results you desire. When starting any new supplement such as Alpha GPC, it would be best to start first with the lowest possible effective dose and increase it gradually over time. Moreover, you might also want to consider consulting your doctor or healthcare provider first before starting with any new medication since a person’s condition and health status may play a role.

Stacking Alpha GPC

Working alone, Alpha GPC is already known to be very potent and has its own nootropic benefits. However Choline sources, in general, are a vital component to any nootropic stacks especially when it is paired with the family of Racetams. Click to read the benefits of Piracetam, Pramiracetam benefits, Phenylpiracetam benefits, Aniracetam, and Oxiracetam benefits.

Alpha GPC paired with a Racetam in a stack is one of the best deals today for your nootropic needs. But, how does Alpha GPC contribute to a synergistic effect to the Racetams? Piracetam, for example, works in our system mainly by influencing the cholinergic system. As a result, in order for it to act efficiently, it needs a steady supply of Acetylcholine. And this quality supply of Choline may be provided by Alpha GPC. In this way, the Alpha GPC-Piracetam stack works in both ways by enhancing cognitive function and by synergizing the effects of each other. Moreover when there is insufficient source of Choline, headaches may occur and is one of the most common side effects of the Racetams. With Alpha GPC at hand, you can surely reach your peak cognitive performance while preventing and/or minimizing the occurrence of headaches.

Since Alpha GPC is water soluble, it is fast acting and does not require a meal for a faster absorption. Although the powder form is the most popular one, Alpha GPC may also be administered intravenously.

Aside from the Racetams, Alpha GPC may also be stacked with other potent nootropics such as Noopept. Your personal stack would greatly depend on your own preference and your needs. However, we should take note that combining supplements needs a thorough understanding of each of the drugs you wanted to use. If you are not sure of your stack, you might want to consult your healthcare provider or do your researches first.

If you are looking to buy Alpha GPC click here.

Review Video:

 

References:

  1. http://www.chemistryexplained.com/A-Ar/Acetylcholine.html
  2. http://examine.com/supplements/alpha-gpc/#summary3-1
  3. http://www.health.harvard.edu/diseases-and-conditions/growth-hormone-athletic-performance-and-aging
  4. http://www.mayoclinic.org/healthy-lifestyle/healthy-aging/in-depth/growth-hormone/art-20045735
  5. http://www.news-medical.net/health/Dopamine-Functions.aspx

Is Alpha GPC the best Choline source?

AlphaGpc Supplement
Many choline supplements are readily available today to choose from, how do you determine which one to take or whether you should naturally get your daily choline intake? In the nootropic world, various kinds of choline supplements can be chosen from. But the question is, how do they differ from one another? And which is the best choline source among them all?

Before naming the different types of choline sources, let’s discuss what choline really is. Choline is a water-soluble nutrient that was first discovered by Adolph Strecker in 1864. By the year 1998, choline was classified as an essential nutrient by the Food and Nutrition Board of the US Institute of Medicine. Our bodies are capable of producing choline however, this is not sufficient for our body’s daily needs. Because of this, choline may be obtained from supplements and a variety of food sources.

Choline is closely related to the Vitamin B-complex family. It plays a role in the structure and integrity of our cell membranes as well as in the process of methylation. Moreover, choline is considered to be the backbone of acetylcholine, an important neurotransmitter in the brain. Acetylcholine or Ach, is vital for the proper functioning of our neurons and is closely associated to one’s memory and cognitive functions (1). Because of this reason, Choline has been one of the essential supplements in the nootropic world and is even used with other supplements for a more potent cognitive benefit. Aside from that, Choline can also prevent and lessen some negative side effects associated with Racetam use.

What are the natural sources of choline?

Before the arrival of choline supplements, how did people get their daily dose? various food sources contain a significant amount of choline in them. It can be found in many plants and animal foods as well as in some processed foods. And, it has discovered that the food with the highest levels of choline is egg. Yes, those eggs that you ate for your daily breakfast is not just your ordinary breakfast meal. Below are the top 10 food sources that have the highest levels in choline with their corresponding specified portion.

Top 10 Choline Sources

1. Eggs
1 whole egg= 146.90 mg 35% DRI/DV

Eggs are considered one of the healthiest foods on earth and have numerous essential compounds in it. Aside from its high levels of choline content, eggs have been recognized as a source of high quality protein. It also contains high amounts of Vitamin B3, Vitamin B2, Manganese, Selenium, Omega-3 fatty acids, amino acids, and so much more. These nutrients each play a vital role in our body’s proper functioning and promotion of a healthy body.


2. Shrimps
4 oz= 153.54 mg 36% DRI/DV

Aside from being an excellent source of choline, Shrimps contain significantly high levels of various important nutrients needed for the body’s proper functioning. To name a few, they are Selenium, Vitamin B12, Protein, Phosphorus, and Copper. Shrimps also play a role as an anti-inflammatory and antioxidant agent as well as having omega-3 fatty acids.


3. Scallops
4 oz= 125.53 mg 30% DRI/DV

Scallops are known for having high levels of choline, Vitamin B12, Iodine, Phosphorus, Protein, and other essential compounds. It serves to promote a healthier cardiovascular system as well as in cancer prevention and age-related cognitive decline.


4. Cod
4 oz= 90.38 mg 21% DRI/DV

Aside from its choline content, Cod provides high levels of other essential compounds such as Vitamin B12, Iodine, Selenium, Phosphorus, Protein, and among many others. It serves to promote a healthier cardiovascular function as well as in cancer prevention.


5. Collard Greens
1 cup= 72.96 mg 17% DRI/DV

Aside from being an excellent source of choline, Collard greens contain significantly high levels of Vitamin K, Vitamin A, manganese, Vitamin C, and other essential compounds. Like Mustard greens, Collard greens also play in cancer prevention by acting to the body’s detox, antioxidant, and anti-inflammatory systems.


6. Brussel Sprouts
1 cup= 63.34 mg 15% DRI/DV

Brussels Sprouts are known for its high levels of choline, Vitamin K content, Vitamin C, and folate levels. It has also been shown to play a role in cancer prevention by acting on the body’s detox, antioxidant, and anti-inflammatory systems.


7. Broccoli
1 cup= 62.56 mg 15% DRI/DV

Broccoli is known to be an excellent source of choline, Vitamin K, Vitamin C, Chromium, and many other essential compounds. Its health benefits include addressing the development of cancer and its relationship to the three metabolic problems: chronic inflammation, oxidative stress, and inadequate detoxification.


8. Swiss Chard
1 cup= 50.23 mg 12% DRI/DV

Swiss Chard is not only one of the most famous vegetables in the Mediterranean but also is one of the most nutritious vegetables. It belongs to the chenopod family along with Spinach, beets, and quinoa. It is an excellent source of choline, Vitamin K, Vitamin A, Vitamin C, and many other essential compounds.


9. Cauliflower
1 cup= 48.48 mg 11% DRI/DV

Cauliflowers contain significantly high amounts of choline, Vitamin C, Vitamin K, Folate, and among many other essential nutrients. It poses its benefits to the human body as an anti-oxidant, anti-inflammatory agent and supports a healthier cardiovascular system.


10. Asparagus
1 cup= 46.98 mg 11% DRI/DV

Asparagus contains a variety of essential nutrients such as choline, Vitamin K, Folate, Copper, and among many others. It has anti-inflammatory and anti-oxidant properties and also supports cardiovascular health. (1)

And, So, What is Alpha GPC?

Alpha GPC or Alpha Glycerylphosphorylcholine which is also sometimes called Choline Alfoscerate, is one of the many variations of choline supplements available today. Many people regard Alpha GPC as the best available choline supplement since it has a slightly different pathway for increasing the levels of Acetylcholine in the brain. One of its unique characteristics is that it is able to pass the blood brain barrier easily thus, delivering its results faster. Aside from the enhanced cognitive function it provides through the influence on the cholinergic system, Alpha GPC also enhances mood through the dopaminergic system and increases strength and lean muscle mass through its influence on the pituitary glands. Alpha GPC also has neuroprotective properties. It serves to maintain the health of our neurons and neuronal communication within the brain. Also, it helps form new brain cells while preventing damage. With this mechanism of action that Alpha GPC possesses, it keeps our brain young, healthy, and functioning at its peak performance.

Buy alphaGPC

Alpha GPC is more concentrated and more effective (alpha gpc’s benefits here) than the other choline supplements on a per weight basis. Although Alpha GPC tends to be more expensive, it is almost twice as strong and potent from Citicoline, another good source of choline. Meaning, Alpha GPC requires a much lower dosage to produce the same effects as the other choline supplements. Let’s say for example, Alpha GPC’s recommended daily dosage is from 250 mg to 500 mg. This dosage is already sufficient to provide you with cognitive and health benefits. Meanwhile, the other choline sources might require you to double that dose in order to see results. In this way, you would be paying less from your money but at a higher quality of choline.

What are the other Choline Sources?

Aside from Alpha GPC, some other good choline sources available today are Centrophenoxine (Lucidril), Choline Bitartrate, and Citicoline. Centrophenoxine is a synthetic version that is derived from DMAE. Due to phospholipid transformation, it may cause a significant increase in Acetylcholine levels in the brain. It has anti-aging and detox properties and provides a boost in the brain’s energy levels.

Choline Bitartrate on the other hand, is another choline source that is fairly cheap to buy and use. Although it has a high concentration of choline, it cannot efficiently pass the blood brain barrier. In this way, a lot of potential effect is put to waste.

Another choline source is Citicoline, also referred to as CDP Choline. One unique characteristic of which is that it undergoes a double conversion – it splits into choline and cytidine, both of which produce cognitive benefits. Citicoline improves mood and energy as well as it promotes a healthier brain.

Choosing a supplement such as that of a choline source, greatly depends upon your choice and preferences. It would be best to try different choline sources and see for yourself which one is most effective for you. You can visit our shop to see which nootropic vendors we recommend and trust.

Video Review of this supplement:

 

References:

  1. http://www.whfoods.com/genpage.php?tname=nutrient&dbid=50

Primer on Choline Sources

choline supplements

Chances are if you are taking piracetam or other racetams and don’t have a proper diet, you may need to supplement on choline to avoid headaches. I will talk about what choline is, the different sources of choline and why you need it in your diet. There are many sources of choline, we will discuss the right one for you.

Choline is a simple water soluble nutrient, and is usually organized in the same group as B vitamins. Recently in 1998 it was classified as an essential nutrient by the American Food and Nutrition of Board, which is part of the Institute of Medicine.

Choline generally helps with the development of the brain and the retention of memory (as tested in baby rats). When pregnant women are given choline, their offspring having a fully developed hippocampus (which helps with long term memory consolidation).

Choline helps your brain with muscle control via acetylcholine — acetylcholine activates muscles, and is a major neurotransmitter in the autonomic nervous system. Research has shown that memory, intelligence, and mood are mediated in part by the metabolism of acetylcholine.

Sources of Choline in Foods: Beef Liver, Cauliflower, Eggs (yolks), Broccoli, Cod Fish, Spinach, Chicken, Kidney Beans among others. The list is in Descending order, meaning the highest choline amount per mg is from Beef Liver in our list.

So, how much choline should be had daily by an adult male? The right Intake amount per day for an adult male is 550 mg/day. Additionally if you are not interested in eating real food (which is the best way to get choline) you can try supplementing. You can see if you can buy beef liver capsules, which are not too expensive.

The second way is directly buying choline supplements, such as Phosphatidylcholine, which has 13% choline based on weight. Choline Salts such as Choline Bitartrate is also a good options as it’s effective and very cheap, and for this reason it is most commonly stacked with Racetams. What we recommend is you take Alpha GPC (benefits of AlphaGPC here) and CDP Choline (also known as Citicoline) as a choline source, as it is much stronger and can be considered nootropic by themselves. The reason Alpha GPC and Citicoline seem “stronger” is because they convert to Acetylcholine more efficiently then say salts. Lastly, there is some anecdotal evidence suggesting that salts causes headaches for those stacking it with racetams.

AlphaGPC is 40% choline by weight as opposed to Phosphatidylcholine which is 13% and is able to cross the blood brain barrier intact. CDP Choline and Alpha GPC both contribute to acetylcholine and PC synthesis, they both raise brain levels of choline effectively, both are naturally occurring, both have helped patients with dementia, both increase AhCE. Now the differences?  AlphaGPC is capable of increasing Growth Hormone (may be good if you are going to be bench pressing. Additionally it has been banned by some athletic organizations). CDP Choline is about half or 18% choline by weight, CDP restores dopamine receptor densities in rodents. CDP raises uridine + choline levels which are thought to work synergistically to create phosphatidylcholine.

In terms of safety and side effects, citicoline has a good safety record (reference provided below). The most common side effects that affected 3% of the patients out of over 2800+ was digestive disturbances and appetite suppressing effects when over 200mg/day was consumed.

Adderall Crash

Adderall Crash

Adderall Crash

Why do some people who consume Adderall also consume L-Tyrosine as an added supplement? Do they really synergize the effects of one another? Let’s take a closer look at these two supplements and find out why they are a great combination indeed.

What is Adderall?

Adderall is a single-entity amphetamine product that combines the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextroisomer of amphetamine saccharate and d, l-amphetamine aspartate monohydrate. Since it is an amphetamine, Adderall acts as a Central Nervous System stimulant and is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and therefore, increase the release of these monoamines into the extraneuronal space. 1

Moreover, Adderall is a prescription drug and is regarded as a controlled substance in the US. In other words, those interested in using the substance cannot just purchase it over the counter. Instead, they must obtain a legitimate prescription from their doctor and then proceed to purchasing it. Since Adderall use can lead to dependence and can potentially be abused, a prescription is absolutely necessary.

 

Adderall and ADHD

Adderall has been regarded as the mainstay medication for the treatment of ADHD. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic neurodevelopmental and behavioral disorder, considered to have neurobiologic origins. It is diagnosed on the basis of the number, severity, and duration of three clusters of behavioral problems: inattention, hyperactivity, and impulsivity. It is the most commonly diagnosed behavior disorder in children. ADHD was originally called minimal brain damage, then minimal brain dysfunction, and in the mid-1900s the term hyperkinetic reaction of childhood was given to the symptoms. It most commonly affects men and has a high rate of heritability.

Although the exact etiology of ADHD is unknown, a combination of organic, genetic and environmental factors is thought to be involved. A variety of factors put a child at risk for symptoms of ADHD:

  • ADHD is seen more often in children who have family members with ADHD, especially the father, the brother or an uncle.
  • There is also an increased incidence of substance abuse, conduct disorders, learning disabilities, depression, and antisocial personality disorder in families of children with ADHD.
  • Chromosomal or genetic abnormalities such as fragile X syndrome have been implicated with ADHD. A sex-linked factor may be operating because the disorder is much more common in boys than girls.
  • Other risk factors include exposure to toxins or medications, perinatal complications, chronic otitis media, head trauma, meningitis, neurologic infections, and mental disorders such as the affective disorders.

 

Pathophysiology of ADHD

The neurotransmitters dopamine and norepinephrine are implicated in the pathophysiology of ADHD. In some children, there may be an absence or insufficiency of these neurotransmitters.

The preceding neurotransmitters normally occur in high concentrations in the brain. Dopamine is a neurotransmitter involved in reward, risk taking, impulsivity, and mood. Norepinephrine modulates attention, arousal and mood.

Impulsiveness

  • It is hypothesized that children who lack these neurotransmitters experience learning difficulties in reading, math, and language, and are prone to impulsivity.
  • The fact that some children with ADHD display decreased symptoms in stressful situations (such as in the doctor’s or principal’s office) provides additional support for this theory, because stress increases the level of norepinephrine.

Hyperactivity

Another neurochemical theory suggests that:

  • The symptoms result from an excess of norepinephrine and/or alteration in the reticular activating system of the midbrain, an area that controls consciousness and attention.
  • This excess abnormality interferes with the function of filtering extraneous stimuli. Consequently, children are unable to focus on one stimulus and are compelled to respond to every stimulus in the environment.

Other theories suggest that symptoms of ADHD result from:

  • Dysfunction in the brain circuits of the behavioral inhibition system
  • Structural abnormalities in the prefrontal cortex, caudate, and thalamus
  • A gene variant known to code for a receptor for dopamine. 2

Adderall may help a person with ADHD pay more attention, concentrate, and stop fidgeting.

What is L-Tyrosine?

Tyrosine is one of the nonessential amino acids in the body and is made from phenylalanine, another amino acid. It is regarded as the building block of protein and can be found in our diet, especially in dairy products, meats, eggs, fishes, and beans. Tyrosine is crucial for the brain’s neurotransmitters dopamine, epinephrine, and norepinephrine (for proper neuronal communication and regulation of mood). Tyrosine also aids in the production of melanin and in the proper functioning of organs responsible for making and regulating hormones. 3

 

Adderall and L-Tyrosine

At present, it is a common practice to take L-Tyrosine when using Adderall. This is mainly because Adderall may cause withdrawal reactions that L-Tyrosine may address. When taken in high doses or in a long duration of time, Adderall may cause severe tiredness, sleep problems, changes in mood and depression. Despite the benefits that Adderall provides, this medication may cause one to become dependent and addicted to it. 4

Adderall can intensify the release of neurotransmitters in the brain and can address problems such as ADHD however, when the storage of these neurotransmitters are used up, low feelings, exhaustion, and a reduced amount of energy the following day may result; this is referred to as Adderall Comedown. With this scenario, users may notice problems with focus and attentiveness, even more than people who have ADHD. L-Tyrosine on the other hand, can counteract this Adderall Crash. Since it acts as a pre-cursor to the preceding neurotransmitters, it can help replenish the levels of those chemicals. It is recommended that L-Tyrosine is taken the day after consuming Adderall, as it can prevent you from experiencing the after effects of Adderall or having the Adderall crash.

If you are supplementing you should definitely consider using Trackmystack as a “nootropic tracker” to manage the effectiveness of your medical stack. To see what others nootropics others are taking you can see the nootropic stack list here.

References:
1 http://www.rxlist.com/adderall-drug.htm

Silliman University Institute of Rehabilitative Sciences Book Compilation Batch 2014.

3 http://umm.edu/health/medical/altmed/supplement/tyrosine

4 http://www.webmd.com/drugs/2/drug-63163/adderall-oral/details#uses

4 Ways To Increase Brain Power Instantly

Simple Ways To Increase Brain Power

President Obama Brain
President Obama is known to have taken modafinil.

Does your brain feel like giving up when you’re studying or participating in mentally challenging activities? Your body wants to push even harder just so your mind can concentrate and focus however, your brain isn’t cooperating. Let’s say you have a great physique and good health, but your brain just isn’t doing its part- you feel mentally drained, exhausted, and lack drive and motivation. You feel numb and can’t recall a single piece of information from your memory nor can you learn new ideas that are presented to you.

Caring for your brain is one of the most important things you could do for your overall health. It can help you think better and faster. Various researchers have now come up with ways to boost your mental intelligence and help you meet your demands at work or school. Here are some of the ways you can increase your brain power.

 

  1. Pills & Supplementation

Presently, there are numerous pills, supplements, and smart drugs that are manufactured synthetically for the sole purpose of enhancing mental intelligence as well as influencing mood and behaviour. Among the most popular smart drugs today are the Racetam family. They are considered nootropics, and they improve one or more aspects of mental function including, but not limited to, memory, motivation and/or attention.

Phenylpiracetam is a synthetic derivative of its parent compound Piracetam and is thought to be 30 to 60 times more potent; it belongs to the Racetam family. The addition of a Phenyl ring to the original structure of Piracetam makes this nootropic very potent, as it can easily pass the blood-brain barrier. The added structure increases the affinity in Norepinephrine and Dopamine, thus promoting vigilant concentration, cognitive alertness, and motor control. Moreover, it resembles the organic compound Phenethylamine, giving it a stimulating and energizing effect. Phenypiracetam has been used by athletes due to its ability to motivate, reduce effects of anxiety and stress, and provides energy like amphetamines. This enhancement in physical performance may be attributed to the increase in Noradrenaline levels. However, the use of this drug has been banned in the Olympics due to its psychostimulatory and cold resistance properties.

Other than the Racetam drugs, there are various supplements also known to increase brain power such as Noopept, Choline sources, Adrafinil, and many others.

 

  1. Play Brain Games

Games, like pills, are just as important in promoting brain power. They have been used to stimulate the brain in specific cognitive functions. It is believed that when you exercise your brain more, your mental intelligence improves.

One game that is gaining popularity is Dual N-Back. It was published under PNAS (Proceedings of the National Academy of Science of the United States of America). Their findings show that the game improves working memory and fluid intelligence- the capacity to think logically and solve problems in novel situations, independent of acquired knowledge. Dual N-Back involves remembering a series of spoken letters and a series of positions of a square at the same time, and then identifying when a letter or position matches the one that appeared earlier. Moreover, this game claims that it also enhances focus and attention, and can improve the symptoms related to ADHD/ ADD. Presently, Dual N-Back is available online.

 

  1. Eat The Right Foods

Supplementing with pills or smart drugs, as well as food intake, can help you improve mental intelligence. There are a lot of nutritious foods in the market, such as green leafy vegetables, that provide us with numerous vitamins and nutrients needed for proper body functioning. However, there are certain kinds of foods that may have a huge impact on our brain’s health and serve to improve cognitive function.

One of the well-known brain power increasing foods includes berries and dark chocolate. Yes you heard it right, your favourite berry jams or chocolates may be very helpful for you. This is because these foods contain high amounts of Flavonoids- these are natural plant pigment compounds found in the food sources mentioned, especially in blueberries. Flavonoids have antioxidant properties and have several health benefits. They also play an important role in the formation of long term memory, also known as long term potentiation, which is brought about by the activation of neurotrophic factor, an important growth hormone in humans. Also, berries contain high amounts of Pterostilbene, a memory-enhancing nutrient. Aside from dark chocolates and berries, other foods that contain high amounts of Flavonoids include wine, green tea, and grape seed extracts.

 

  1. Have The Right Diet Plan

Another interesting way to boost your intelligence is through your diet. The Paleo diet, also referred to as the Caveman Diet or Stone Age Diet, is a diet plan based on the foods that our ancestors may have eaten. It is basically a high-protein and high fiber eating plan that aids in the prevention of diabetes, heart disease, cancer, and numerous other conditions. The diet promotes the consumption of lean meats and fish, fruits and vegetables, and healthier fats while avoiding processed foods, wheat, dairy, grains, and legumes.

With regards to our mental health, there have been multiple studies verifying that the Paleo diet maintains and promotes brain health and cognitive function. A healthy stomach as well as essential nutrients and right nutrition yields to a healthy brain. Cranial nerve 10 or Vagus nerve is responsible for the communication between the stomach and the brain, and anything that upsets the digestive system has negative consequences to our mental health. The Paleo diet keeps our gut healthy and therefore, supports our mental health. It protects our brain from tissue damage and provides all the micronutrients and helpful bacteria that our brains need to thrive.

Closing Thoughts…

As numerous research studies are being conducted nowadays, a lot of foods, supplements, and diets, with the aim of improving mental intelligence, have already been discovered. A combination of these methods may be very powerful and effective in boosting your brain power and fuelling you in your daily activities. As a result, you should be resourceful and motivated to reach your goal in improving mental performance.

Click here to visit our shop to get started right away.

 

Sources/References:

http://brainworkshop.sourceforge.net/

http://www.news-medical.net/health/What-are-Flavonoids.aspx

http://www.webmd.com/diet/paleo-diet

http://paleoleap.com/brain-on-paleo/