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SAMe vs Agmatine

SAMe vs Agmatine Comparison, Similarities & Differences


Read full SAMe Review


Read our SAMe Review

SAMe, also known as S-Adenosyl Methionine, is a supplement made from Adenosine Triphosphate and Methionine and is used as a treatment for mild depression, boosting mood and nergy levels. Nootropic benefit is thought to be derived from the fact that SAMe may reduce brain inflammation, which preserves optimal brain functioning. This substance is believed to help the brain to produce and break down Serotonin, Melatonin, and Dopamine. Moreover, some studies show that it has the ability to inhibit the growth and development of cancer tumor cells and may be helpful in improving mood for patients with Parkinson's disease.

This is a natural compound that was discovered in the early 1900s when scientists decarboxylated the amino acid arginine meaning to say, the carboxylic acid group was removed from Arginine. From a nootropic perspective, agmatine is known to aid in neurotransmission within the brain. It accomplishes this by influencing ion channels, membrane transportation, modulation of nitric oxide, and metabolic processing of polyamine. It is able to cross the blood-brain barrier and functions to improve mood and reduce anxiety. It is also known to influence the Alpha-2 receptor in the adrenergic system and can inhibit some NMDA receptors.



Agmatine sulfate, Clonidine-displacing substance, 4-aminobutylguanidine, Decarboxylated arginine


No dosage data available


No dosage data available

Side Effects

Some side effects associated with SAMe usage include headaches, nausea, diarrhea, anxiety, restlessness, insomnia, and heart palpitations.


Total Users

There are no users taking this supplement.

There are no users taking this supplement.




Evidence-Based Effects

  • Pain - Decreased


No data available

Medical Conditions

No data available

Medical Symptoms

No data available


No data available

Commonly Paired With

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Price & Brand

Editors RecommendationCertified Pick:

Buy Agmatine Supplement
Cost: $16.95
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