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Huperzine A vs Centrophenoxine

Huperzine A vs Centrophenoxine Comparison, Similarities & Differences

Huperzine A

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Huperzine A, also called selagine, is an alkaloid compound commonly used to treat Alzheimer's disease and other neurodegenerative diseases. It is known for its ability to improve memory and cognitive abilities by increasing acetylcholine levels in the brain and by blocking the action of cholinesterase. This is particularly effective when studying or trying to learn any new material. Also, it acts as an antagonist of the NMDA receptor and has neuroprotective properties by protecting neurons from damage due to glutamate, peroxides, and beta-amyloids. However, it cannot be medically endorsed as a treatment until additional research is conducted.

Centrophenoxine is one of the best cholinergic drugs in the market today that is used to treat symptoms of senile dementia and Alzheimer's disease. It is an ester of DMAE or dimethylethanolamine and 4-chlorophenoxyacetic acid. Centrophenoxine possesses to be a promising nootropic knwon to clinically improve memory and improve general cognition. Also, it increases cellular membrane phospholipids. Centrophenoxine works as a precursor to Acetylcholine, an important neurotransmitter for proper brain functioning and is typically associated with increased brain plasticity and is involved in important cognitive processes, especially memory formation and neuromuscular control. Its mechanism is that it promotes memory formation by building nbnew neurons and even synapses between those neurons. These then, contribute to an improved overall thought and cognition, and enhanced transmission of information and creative thought.


1R, 9S, 13E-1-amino-13-ethylidene-11-methyl-6-azatricyclo- [ 2, 7 ]trideca-27, 3, 10-trien-5-on, Qian Ceng Ta Huperzia Serrata

Centro, Centrophenoxine, Lucidril, Meclofenoxate, meclofenoxateor, PCPA paracholrphenoxyacetic and DMAE dimethylaminoethanol



No dosage data available

250 mg, taken up to 2 times per day.

No dosage data available

Side Effects

Huperzine A appears to be safe even with daily use.

Centrophenoxine is generally safe to use however, possible side effects may include nausea or mild dizziness.


Total Users

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4.67/5 based on 4 user votes

4.33/5 based on 3 user votes

Evidence-Based Effects


No data available

Medical Conditions

No data available

Medical Symptoms

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No data available

Commonly Paired With

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Price & Brand

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