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Fish Oil vs Trimethylglycine

Fish Oil vs Trimethylglycine Comparison, Similarities & Differences

Fish Oil

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Fish oil is a form of omega-3 fatty acids and perhaps the most common type. Although many people are hopping on the krill oil bandwagon, there is still evidence supporting the usage of purified fish oil for mental benefits. Although improvements in cognition are not usually immediate, many individuals have noticed improved attention, mood, and organization of thinking as a result of fish oil supplementation. Omega 3's are essential for our bodily functions since it ensures that our cell membranes are fluid which is very imprtant for synaptic plasticity and neuronal communication.

Trimethylglycine was originally referred to as betaine since it was discovered in sugar beets during the 19th century. It was the first betaine discovered and is an organic compound that occurs in plants such as in broccoli, spinach, grains, and shellfish. Generally, Trimethylglycine serves its purpose by decreasing high levels of the amino acid homocysteine, which is a risk factor for having heart diseases and stroke. In addition to that, Trimethylglycine may help with the treatment of Homocystinuria, a hereditary condition that causes homocysteine to accumulate in the blood at toxic levels. This condition has been associated with excessive tiredness, abnormal bone development, weak bones, and blood clots. On the other hand, researches have found that Trimethylglycine may have hepatoprotective properties and could prevent fatty liver deposits due to chronic alcohol use, insufficient protein intake, obesity, and diabetes.


Eicosapentaenoic Acid, EPA, Docosahexaenoic Acid, DHA, Omega-3 fatty acids, Omega-3, Omega 3, N-3 Fatty Acids

Betaine, TMG, Glycine betaine, oxyneurine, lycine



No dosage data available

It has been found that the lowest effective dose for Trimethylglycine is 500mg taken throughout the course of the day.

No dosage data available

Side Effects

When taken at extremely high dosages, fish oil may produces excessive bleeding, gastrointestinal problems, and allergic reactions.

Trimethylglycine has been shown to produce some minor side effects such as nausea, diarrhea, and upset stomach.


Total Users

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4.00/5 based on 3 user votes


Evidence-Based Effects

  • Anxiety - Decreased
  • Blood Pressure - Decreased
  • Cell Adhesion Factors (aka sCAM-1 - Increased
  • Cortisol - Decreased
  • Depression - Decreased
  • Endothelial Function - Increased
  • Homocysteine - Decreased
  • Inflammation - Decreased
  • Lipid Peroxidation - Increased
  • Memory - Increased
  • Natural Killer Cell Activity - Decreased
  • Photoprotection - Increased
  • Platelet Aggregation - Decreased
  • Stress - Decreased
  • Symptoms of Bipolar Disorder (aka Manic-depressive disorder) - Decreased
  • Symptoms of Systemic Lupus Erythematosus - Decreased
  • TNF-Alpha (aka TNF-α - Decreased
  • vLDL-C - Decreased
  • Infant Birth Weight - Increased

  • Cortisol - Decreased
  • Homocysteine - Decreased
  • LDL-C - Increased
  • Liver Enzymes - Decreased
  • Total Cholesterol - Increased


No data available

Medical Conditions

No data available

Medical Symptoms

No data available


No data available

Commonly Paired With

No data available

Price & Brand

Editors RecommendationCertified Pick:

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