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Can You Develop A Tolerance For Nootropics With Regular Use?

nootropics toleranceSince the advent of nootropics in the 1960’s, supplements have helped us with preventative health and optimization in many areas. Nootropics were to treat diseases such as Alzheimer’s but are readily used for off-label purposes such as: enhancing things like, learning capacity, memory, and decision making.

There are additional advantages like helping protect the brain from oxidative damage and to enhance the health of billions of neurons. Furthermore, scientists keep studying ways for how Nootropics could be utilised daily to help patients with clinical conditions such as: ADHD, stroke and trauma patients and even cognitive degenerative conditions that come with age such as dementia.

A valid question thus arises which is, what are the certain tolerance levels for nootropics if used on a daily basis:

Can Supplementing Nootropics Cause A Tolerance Build Up

Tolerance is an issue with various pharmaceuticals and supplements whereby they turn out to be less efficient after some time. A major concern among new Nootropic supplement users’ is concerning the effectiveness of the supplement overtime. The nootropic Phenibut and Sulbutiamine come to mind when thinking of tolerance build ups.

Other’s are concerned about experiencing withdrawal after they stop using nootropics; and thus a dependency on the drug or supplement. This is not how most nootropics are made, and by definition, nootropics are suppose to help the brain whether it is for the short term or for immediate use. It is unlike the movie Limitless, where the drug NZT 48 when stopped causes the user to instantly go back to baseline IQ levels. Ayurvedic supplements such as Bacopa Monnieri for example take time to build up and generally “help” the brain and so stopping it suddenly has no withdrawal or immediate “dumbing” effects. Other smart drugs such as Modafinil or Adrafinil for example will peak in 3 hours and have a half life of about 15 hours, where after the effects are gone.

We urge you to explore our list of nootropic supplements as each one has a unique property.

Thus, your body can definitely build up tolerance for some Nootropic supplements. You may encounter indications of “mental addiction” to these supplements despite the fact that are no withdrawal symptoms or signs of physical addiction. For such Nootropics, there are various ways you can practice to make sure that you don’t develop a tolerance when using them.

We should also note that many of the Nootropics are planned for daily intake and are pretty much unlikely to build up a tolerance over the time. Some of the supplements will really have growing impacts that rise in concentration with regular doses, as mentioned above.

Nootropics such as Piracetam and Aniracetam are known to produce long term benefits as you consume them. This is because of the mechanism of action of Racetams generally.  Memory capacity and synaptic plasticity are two things which may be possible to increase over time. Similarly, nootropics with any kind of stimulant impact prompting high energy levels are more inclined to building up a tolerance and are ideal to be used occasionally or be cycled with some exceptions, e.g. Rhodiola Rosea.

What Is Tolerance?

Tolerance is basically when there is a diminished response to a drug being consumed as your body adapts to the continual presence of the drug or supplement in your system (note: this is different than Resistance). Overtime it turns increasingly difficult for the drug to act as intended. It can be discouraging when you notice that you don’t encounter the same advantages as you did when you first started.

In a few cases, to obtain the same effects as before, you may need to progressively increase your dose but that is not good advice under any circumstance (unless if approved by your physician), even with nootropics which have very low toxicity levels.tolerance to nootropics

There may be multiple reasons why tolerance develops, one of the reason could be that you may be producing less neurotransmitters or whatever substance the nootropic was increasing in your system, or it could be that you are already functioning at peak capacity.

The receptors of specific neurotransmitters may likewise turn out to be less sensitive implying that a greater amount of the neurotransmitter should be discharged all together for the same impact to take place.

There are various different tolerances which can occur, some are very long lasting, it may take months for the body to readjust. Caffeine is great example of such a tolerance. When you become dependent on caffeine; the receptors in your body begin to shrink and become less sensitive. The outcome is that you have to consume more caffeine so as to feel the same amount of energy and alertness. There are other sorts of tolerances which are brief and they balance out in a couple of hours after the supplement is consumed. An example is the stimulant Ephedrine. Ephedrine wears off much quicker than caffeine and it might actually last only 15 minutes.

Simple Way to Avoid Tolerance to Nootropics

The first step is to figure out if that specific nootropic has tolerance issues.  Then, if you have decided to take a Nootropic that has a high chance of leading to tolerance, you may take the similar route as bodybuilders and weightlifters when training: Cycling. A cycle is mainly a routine with phases of use (or training) trailed by phases of non-use (or not training).

So, perhaps as opposed to using a drug like Adrafinil for 30 days in a row, you may use it for a week, then cut back your intake for a week, after that use it 4 days with 3 days off. This is how a cycle works and it keeps the body from adjusting, the name of the game is random on and off days. Some anecdotal evidence suggests that for stimulants you may be able to take for 6 days on with 1 day (perhaps in the middle of the week) off for example, and still reap the same benefits or close to what you would if you had 4 days on and 3 off.

Certain nootropics which are particularly thought to act as stimulants are significantly more likely to bring about a level of tolerance in its users. They have to be cycled or utilized as part of a nootropic stack. These are a only a handful of nootropics that have tolerance issues.

Learn to Cycle and Stack Nootropics Properly

nootropics tolerance symptomsCycling and stacking nootropics needs to be done based on your goal. For instance, someone hoping to enhance their memory may have an altogether distinctive routine than a one hoping to improve brain health and defer the impact of age associated cognitive decline or Alzheimer’s.

First decide on your goal and after that discover which nootropics may help you accomplish it. Likewise find if there any extra nootropics that may potentiate the impacts of your drugs to further elevate the results. This can save you from taking too much of one drug as well and could possibly save you money, this experimentation can be made simpler by using TrackMyStack to determine when to cycle and the efficacy of certain nootropics.

Start with your primary nootropic agent, so for memory enhancement this may be Noopept or Phenylpiracetam. For Neuronal communication help, Huperzine or Centrophenoxine.  Make plans on cycling anything with stimulant like effects in and out every now and then. You can alternatively see if you get the same effect by picking a similar supplement as well, e.g. maybe Sulbutiamine to Rhodiola. Make sure you discuss all your choices with your primarily health care provider before switching back and forth and when in doubt, your better of without!

Top 10 Most Effective Nootropic Supplements

nootropic supplementsWhat are the most effective nootropics that you can try? Nootropic supplements are also known as brain boosters and cognitive enhancers because of their ability to enhance mental performance and produce various positive effects to the brain. This includes improved speed of recall, heightened mental energy, improved short-term and long-term memory, enhanced mental clarity, and improved concentration.

These supplements may also improve the communication between neurons, thus enhancing their overall effectiveness and could promote a much healthier brain. This leads to better executive function, enhanced fluid intelligence, even more creative thought, and improved problem-solving. This means not all nootropics are taken “when you need a boost” but can be taken as a “vitamin” for neuroprotective reasons as well, think about it, if you can take a supplement for your body, why not to a larger extent for your brain as well.

There are a lot of clinical cases where some of these nootropics have helped and they include: attention deficit hyperactivity disorder (or ADHD), Parkinson’s disease, dementia, Alzheimer’s disease, as well as age specific cognitive decline. These benefits are the reason nootropics are being widely used by many people, for some, many times throughout the day. Below we list our top 10 supplements (& drugs) that may be of use to you. CONSULT YOUR HEALTH CARE PROVIDER BEFORE STARTING A REGIMEN WITH THESE. Consider this article a guide for beginners to get know about what’s out there and what their functions are.

There are many types of supplements available and this may be overwhelming for those looking to start. We wanted to make it easier by listing the top nootropic supplements in order of  most potent and most effective nootropics to “least” in our top 10. Least is in quotes because different supplements provide different benefits and have different side effects. By no means is this list comprehensive.


What is it? Modafinil is a smart drug that enhances energy levels and alertness – particularly in individuals who do not usually get enough sleep. User reports suggest that it gives them the desired mental energy boost that they need better than caffeine and other stimulants do. Hence, it has gotten to be well known for off-label use as a focus enhancer. Modafinil is clinically prescribed for individuals who suffer from sleep disorders such as obstructive sleep apnea, narcolepsy, among other sleep related conditions.

What are the benefits of Modafinil?

Modafinil has appeared to help individuals stay alert and focused, and additionally clear their mind, if they lack sleep or are sleepy. Researchers have effectively demonstrated a relationship between the utilization of this medication and retaining intellectual capacity in a sound state against variables such as absence of sleep. Be that as it may, not every one of them could associate Modafinil to a change in psychomotor capacity in human test subjects.

Regardless of its beneficial outcomes on concentration enhancement, focus and short-term memory, it hasn’t demonstrated huge enhancements in cases that concerned healthy adults with attention deficit hyperactivity disorder (or ADHD). Then again, the same condition found in kids appeared to benefit from the utilization of Modafinil to the same or more prominent degree as methylphenidate, the prescribed medication of choice for that purpose.


What is it?

Noopept is primarily used to enhance learning capacity, memory, and concentration. It is known to be one of the more potent cognitive enhancers and considered to be much more effective than most other synthetic nootropics especially when compared to other racetams.

What are the benefits of Noopept?

This supplement provides numerous benefits related to the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. It is thought that these combined actions are the reason for the wide range of cognitive benefits.

The most well-known benefit of this drug is it’s ability to significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, better mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and logic processing.


What is it?

Adrafinil is a drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. While as Modafinil is a controlled substance, Adrafinil is not, it metabolizes in the liver to form Modafinil. It can be a bit harsh on the liver for this very reason, so it is not advised to supplement this drug frequently and if done so, your liver enzyme levels should be monitored closely.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.


What is it?

Pramiracetam is an “advanced version” of Piracetam, it’s mechanisms of action too is very similar, it includes binding to Acetylcholine receptor sites in the brain and inhibiting their desensitization in order to increase the action potential of the neurons. Pramiracetam is one of the most powerful Nootropic supplements available. It has a very high bioavailability and is a fat soluble racetam and is noted to have long half-life.

What are the benefits of Pramiracetam?

Pramiracetam is known to be one of the “purer” Nootropics. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.


What is it?

Like pramiracetam, phenylpiracetam is also an “advanced and stronger” version of Piracetam. It contains a Phenyl molecule group attached to the original Piracetam and is known to be 60x more concentrated. This is why Phenylpiracetam provides better benefits may be a considered a step up from Piracetam.

What are the benefits of Phenylpiracetam?

Phenylpiracetam is known by its ability to help improve general tolerance to stress and cold. According to its user reviews, Phenylpiracetam could increase a person’s memory, focus, learning capacity, concentration, attention span, as well as mental energy. Additionally, it helps enhance physical performance, promotes intense focus, and improve workout recovery times.


effective nootropic supplementsWhat is it?

Sulbutiamine was originally synthesized in Japan, it is a synthetic version of Thiamine (or Vitamin B1) and is primarily used to enhance the overall energy levels of the brain. Sulbutiamine is not really considered a “true” Nootropic; however, it seems to go very well with other supplements that is why it is commonly stacked as part of a larger nootropic regimen.

What are the benefits of Sulbutiamine?

Sulbutiamine helps a person relax and promotes a feeling of general well-being. It improves the ability to concentrate and focus as well as enhancing attention span.


What is it?

Aniracetam belongs to the Ampakine family and is considered as a Racetam. It has the ability to provide mood boosting effects and reduces the levels of anxiety and stress and thus it is known as a potent anxiolytic. Aniracetam could greatly benefit those who suffer from depression, social anxiety, and other mood disorders.

What are the benefits of Aniracetam?

Some of the benefits of Aniracetam include improving focus, memory, and attention span. Aniracetam is not considered a CNS stimulant. However as a user it’s common to experience a initial boost of energy followed by feelings of relaxation. It is said this nootropic also increases memory Input and Output (I/O reference: Dave Asprey), meaning it helps with recall and speech fluency, however consider this anecdotal.

Huperzine A

What is it and what are its benefits?

Huperzine A is a herbal nootropic that is widely used by people for it’s ability to help inhibit an enzyme that degrades the learning neurotransmitter, acetylcholine. It is derived from a plant called Huperzia Serrata, which is abundant in China. Acetylcholine is one of the most important neurotransmitters in our body as it helps improve numerous cognitive functions and processes and enhances memory.


What is it and how does it work?

5-HTP is a chemical that is synthesized in the human body via L-Tryptophan and is converted into Serotonin inside the brain. Like acetylcholine, serotonin is also among the most important neurotransmitters since it is also responsible in promoting normal sleep patterns and regulates mood. It could also prevent over excitation of the brain and helps with better focus.


What is it?

Choline is a substance that can be found in small amounts in various types of food products that we consume every day. It is one of the basic components for any nootropic/cognitive enhancement supplement stack. Choline sources such as Choline Bitartrate, or CDP Choline function as a direct precursor for the production of Acetylcholine, thus it is important to supplement or consume it via food to make sure you have adequate levels.

What are the benefits of Choline?

Some studies show that choline could better potentiate the effectiveness of various nootropic drugs. Headache are considered to be a common side effect following the intake of racetams, a depletion of choline could be the culprit. Although it really does depends on your own biology, as it could be many other factors. Many will have you believe that you must supplement choline with any racetam and that is simply not the case. It should be consumed “as needed”, a little trial and error will you determine the right dose, but stay within the suggested dose on the label.

Based on TrackMyStack Users

Our users are taking the following nootropic supplements for cognitive enhancement, this report is updated live and can be accessed here to view the live version.
nootropic supplement report

Gender breakdown of the above report:

nootropic report by gender




Limitless Drug NZT-48

The Real Limitless Drugreal limitless pill

The film Limitless, which stars Bradley Cooper, Arbie Cornish, and Robert Deniro, has made a huge impact on society. This is mainly because it revolves around mental capabilities and how we could unlock our full potential just by taking a single pill- the NZT 48 drug.

What is NZT?

In the film, NZT-48 is such a powerful drug that it makes Bradley Cooper, known as Eddie Mora in the movie, unlock his full potential. He is superhuman when he takes the pill; not only is he able to use 20% of his brain’s capacity, but he is able to go much beyond that.

In  reality, we use 100% of our brain, not all the time, but we use different parts of our brain for different things, the 20% of our brain usage is a urban myth. Anyways Bradley becomes the smartest living creature, doesn’t run out of energy, is able to learn languages and make a lot of money in the stock market. Would this be something you would take?

Does NZT48 really exist? The truth is, NZT-48 is just a creation of fiction and it was created to sell the movie. So the question is, why do we have the need to talk about this topic? Does it only give us a dream, or a false hope of using our brain’s potential 100% of the time? Even though NZT-48 is not real, there’s supplements and drugs referred to as Nootropics and they are starting to appear promising.

What are Nootropics and are they close to NZT?

By definition, nootropics are drugs that can protect your brain, enhance memory and/or other cognitive functions. They serve to promote enhancement in memory and facilitation of learning (1). Among the most famous nootropics today is the Racetam family and the first nootropic drug to be used widely was Piracetam, a synthetic derivative of GABA, also known as aminobutyric acid. You don’t need to remember this, although if you were on it, it wouldn’t be hard..would it?

Although its mechanism of action is still not fully understood, studies show that Piracetam positively affects the release of neurotransmitters in our brain and their receptor-binding capabilities. This improves cell functioning and leads to cognitive enhancements such as more efficient and easier memory formation, and memory recall. Also, Piracetam is involved in the activation of Acetylcholine, an important neurotransmitter in the brain related to memory processes and development (2). It is fairly easy to buy online as well and is considered safer than table salt (when you look at the LD50).

At present, various nootropics have already been discovered; these are much more potent than the parent compound Pireacetam. These smart drugs have a wider array of cognitive benefits and improve other areas like mood, behaviour, energy, and others. One such smart drug is Noopept — it is believed to be 1000x more potent than its derivative Piracetam. Other familiar nootropics also include Phenylpiracetam– also a derivative of Piracetam and is believed to be 30-60x more potent than its parent compound Piracetam.

One notable feature is that it has a phenyl ring added to the original structure, giving it a higher affinity for Norepinephrine and Dopamine, and making it easier to cross the Blood-Brain Barrier or BBB. Moreover, it enhances physical performance and gives stimulating and energizing effects through an increase in Noradrenaline levels.

Although athletes find this very useful, it is banned in the Olympics due to its psychostimulatory and cold resistance properties. Phenylpiracetam also has the ability to motivate and reduce the effects of anxiety and stress. Finally, other various smart drugs known in the market today include Pramiracetam, Aniracetam, Alpha GPC, Citicoline, Phenibut, and many more.

Through gradual research and experiment, a lot of smart drugs today show a large resemblance to NZT-48. The above are marketed as supplements but the FDA would not classify them as supplements. There are some drugs that are approved by the FDA (in America, it is the regulatory agency, and we will talk about that below).

Is Modafinil the original limitless pill?

modafinil limitless review

Is modafinil really the original nzt48 pill? Consider Adrafinil, as the legal limitless pill and is available for sale online. Is it also a fictional drug like the NZT-48? Well here is the good news, Modafinil in contrast with NZT48, is a real-life drug. Yes you heard it right, Modafinil is not just available on our television screens, but we can actually buy it. But how is Modafinil related to the limitless pill NZT-48? Modafinil was actually the inspiration for NZT-48. It is used as a wakefulness-promoting agent primarily used to treat Narcolepsy (a condition causing excessive daytime sleepiness), shift work sleep disorder, and other sleep disorders.

Its wakefulness-promoting properties and increase in energy levels may be attributed its role as an adrenergic receptor agonist. It activates orexins/hypocretins (these are brain peptides) thus, increasing dopamine, norepinephrine and histamine levels. Moreover, Modafinil serves to improve memory and brain function through enhanced neuronal stimulation; more specifically, positive stimulation of Glutamate receptors and inhibition of Glutamate breakdown.

Because of Modafinil’s mechanism of action, it is the drug that is the closest thing to limitless pill NZT 48. Soon we will also review Donepezil which many now consider a limitless like pill as well. Modafinil is obviously a prescription drug and there can be many side effects, however with a good diet and proper nootropic supplementation you can ‘generally’ always feel noticeably smarter than your baseline, it is like body building, you can take supplements to go from your baseline to your absolute genetic potential but then as bodybuilders take steroids, drugs like modafinil can be used to push the brain to it’s capacity and thus we don’t recommend anyone try it right off the bat, especially not without consulting a physician.


Although NZT-48 may just be a fictional drug–the idea is real, there are a lot of promising smart drugs in the market that offer similar benefits. One supplement may provide benefits in one facet, but when stacked with others may be the complete regimen you need to feel more intelligent. We urge you to browse different stacks and see the results people are getting. A popular example of stacking is the combination of Racetams with Cholinergics.

For instance, the actions of racetams are attenuated due to an increased level of neurotransmitters that are essential for brain functioning. Be sure to track your results over time to see how the changes are affecting you. If you would like to skip nootropics and go straight to a nzt like smart drug consider buying adrafinil (modafinil precursor) here.