Since the advent of nootropics in the 1960’s, supplements have helped us with preventative health and optimization in many areas. Nootropics were to treat diseases such as Alzheimer’s but are readily used for off-label purposes such as: enhancing things like, learning capacity, memory, and decision making.
There are additional advantages like helping protect the brain from oxidative damage and to enhance the health of billions of neurons. Furthermore, scientists keep studying ways for how Nootropics could be utilised daily to help patients with clinical conditions such as: ADHD, stroke and trauma patients and even cognitive degenerative conditions that come with age such as dementia.
A valid question thus arises which is, what are the certain tolerance levels for nootropics if used on a daily basis:
Can Supplementing Nootropics Cause A Tolerance Build Up
Tolerance is an issue with various pharmaceuticals and supplements whereby they turn out to be less efficient after some time. A major concern among new Nootropic supplement users’ is concerning the effectiveness of the supplement overtime. The nootropic Phenibut and Sulbutiamine come to mind when thinking of tolerance build ups.
Other’s are concerned about experiencing withdrawal after they stop using nootropics; and thus a dependency on the drug or supplement. This is not how most nootropics are made, and by definition, nootropics are suppose to help the brain whether it is for the short term or for immediate use. It is unlike the movie Limitless, where the drug NZT 48 when stopped causes the user to instantly go back to baseline IQ levels. Ayurvedic supplements such as Bacopa Monnieri for example take time to build up and generally “help” the brain and so stopping it suddenly has no withdrawal or immediate “dumbing” effects. Other smart drugs such as Modafinil or Adrafinil for example will peak in 3 hours and have a half life of about 15 hours, where after the effects are gone.
We urge you to explore our list of nootropic supplements as each one has a unique property.
Thus, your body can definitely build up tolerance for some Nootropic supplements. You may encounter indications of “mental addiction” to these supplements despite the fact that are no withdrawal symptoms or signs of physical addiction. For such Nootropics, there are various ways you can practice to make sure that you don’t develop a tolerance when using them.
We should also note that many of the Nootropics are planned for daily intake and are pretty much unlikely to build up a tolerance over the time. Some of the supplements will really have growing impacts that rise in concentration with regular doses, as mentioned above.
Nootropics such as Piracetam and Aniracetam are known to produce long term benefits as you consume them. This is because of the mechanism of action of Racetams generally. Memory capacity and synaptic plasticity are two things which may be possible to increase over time. Similarly, nootropics with any kind of stimulant impact prompting high energy levels are more inclined to building up a tolerance and are ideal to be used occasionally or be cycled with some exceptions, e.g. Rhodiola Rosea.
What Is Tolerance?
Tolerance is basically when there is a diminished response to a drug being consumed as your body adapts to the continual presence of the drug or supplement in your system (note: this is different than Resistance). Overtime it turns increasingly difficult for the drug to act as intended. It can be discouraging when you notice that you don’t encounter the same advantages as you did when you first started.
In a few cases, to obtain the same effects as before, you may need to progressively increase your dose but that is not good advice under any circumstance (unless if approved by your physician), even with nootropics which have very low toxicity levels.
There may be multiple reasons why tolerance develops, one of the reason could be that you may be producing less neurotransmitters or whatever substance the nootropic was increasing in your system, or it could be that you are already functioning at peak capacity.
The receptors of specific neurotransmitters may likewise turn out to be less sensitive implying that a greater amount of the neurotransmitter should be discharged all together for the same impact to take place.
There are various different tolerances which can occur, some are very long lasting, it may take months for the body to readjust. Caffeine is great example of such a tolerance. When you become dependent on caffeine; the receptors in your body begin to shrink and become less sensitive. The outcome is that you have to consume more caffeine so as to feel the same amount of energy and alertness. There are other sorts of tolerances which are brief and they balance out in a couple of hours after the supplement is consumed. An example is the stimulant Ephedrine. Ephedrine wears off much quicker than caffeine and it might actually last only 15 minutes.
Simple Way to Avoid Tolerance to Nootropics
The first step is to figure out if that specific nootropic has tolerance issues. Then, if you have decided to take a Nootropic that has a high chance of leading to tolerance, you may take the similar route as bodybuilders and weightlifters when training: Cycling. A cycle is mainly a routine with phases of use (or training) trailed by phases of non-use (or not training).
So, perhaps as opposed to using a drug like Adrafinil for 30 days in a row, you may use it for a week, then cut back your intake for a week, after that use it 4 days with 3 days off. This is how a cycle works and it keeps the body from adjusting, the name of the game is random on and off days. Some anecdotal evidence suggests that for stimulants you may be able to take for 6 days on with 1 day (perhaps in the middle of the week) off for example, and still reap the same benefits or close to what you would if you had 4 days on and 3 off.
Certain nootropics which are particularly thought to act as stimulants are significantly more likely to bring about a level of tolerance in its users. They have to be cycled or utilized as part of a nootropic stack. These are a only a handful of nootropics that have tolerance issues.
Learn to Cycle and Stack Nootropics Properly
Cycling and stacking nootropics needs to be done based on your goal. For instance, someone hoping to enhance their memory may have an altogether distinctive routine than a one hoping to improve brain health and defer the impact of age associated cognitive decline or Alzheimer’s.
First decide on your goal and after that discover which nootropics may help you accomplish it. Likewise find if there any extra nootropics that may potentiate the impacts of your drugs to further elevate the results. This can save you from taking too much of one drug as well and could possibly save you money, this experimentation can be made simpler by using TrackMyStack to determine when to cycle and the efficacy of certain nootropics.
Start with your primary nootropic agent, so for memory enhancement this may be Noopept or Phenylpiracetam. For Neuronal communication help, Huperzine or Centrophenoxine. Make plans on cycling anything with stimulant like effects in and out every now and then. You can alternatively see if you get the same effect by picking a similar supplement as well, e.g. maybe Sulbutiamine to Rhodiola. Make sure you discuss all your choices with your primarily health care provider before switching back and forth and when in doubt, your better of without!