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The Correct Modafinil Dose – 100mg, 200mg or 400mg Per Day?

modafinil dosageModafinil is a popular wakefulness promoting agent used by millions of patients everyday, though it started as a drug for narcolepsy, over time (reluctantly, see: Jet Lag syndrome) the FDA has allowed Cephalon to market it for other symptoms as well. It is a popular medication now used off-label to manage ADHD, aid in Weight loss and taken as  smart drug to boost mental capacity temporarily. The advantages of Modafinil are appealing and not easy to resist for those with the above aforementioned symptoms or goals.

When an individual decides to take Modafinil, they should first do their part and understand the procedure of how to carefully consume the drug. An important question one should ask before taking Modafinil for the first time is what’s the right dosage to avoid the side effects, 50mg, 100mg, 200mg, 400mg?

Modafinil’s Story

Modafinil was first developed at Lafon Laboratories in France in the late 1980’s. Modafinil was discovered after the invention of a chain of other chemicals categorized as Benzhydryl Sulfinyl. Most importantly, these included Modafinil’s precursor compound Adrafinil. Adrafinil was first found to improve wakefulness & alertness, later it was offered to treat people suffering from Narcolepsy in 1986 in France.

Modafinil was discovered as primary Metabolite and active component for Adrafinil. It was observed that Modafinil had lesser side effects & greater potency than its precursor. Although the use of Modafinil has grown exponentially in countries like UK and US, Adrafinil is used as a substitute to Modafinil as the drug is available without a prescription. Modafinil has been sold in United states from 1998, under the name Provigil, which is distributed by Cephalon Inc (The parent company of Lafon from 2001).

FDA, Modafinil & Dosage for ADHD

The FDA (Food and Drug Administration) has approved Provigil for treating shift work sleep disorder, narcolepsy and for hypopnea (Obstructive sleep apnea). Although some other medical conditions were found to benefit from Modafinil, FDA has failed to identify any additional benefits, even til this day.

Many studies were conducted and demonstrated how Modafinil can be used in treating ADHD in children and adults while carrying very few side effects, addiction, withdrawal or abuse when compared with similar drugs like Adderall or Ritalin. There were negative reactions in children aged 7 to 12 in about 20 of 100 patients, and for this reason the FDA Advisory committee in a vote of 12 to 1 decided that Cephalon would not be allowed to create the drug Sparlon (Modafinil in 345mg to 420mg doses) which was to be used for ADHD in children — which also happens to be the dose that Cephalon considered to be the “effective” dose in treating ADHD.

Off-Label and Recreational Modafinil Use

modafinil dose guideModafinil’s off-label use accounts for 90% of it’s sales (2004). Additional conditions that the drug Modafinil has been used include psychiatric and neurodegenerative disorders. This could also include treatment for Schizophrenia, Parkinson’s disease, bi-polar disorder, depression, medicine-influenced Fatigue or disease-related. ¹

Modafinil was discovered to produce a stabilized effect on mood, creating positive thoughts, well-being and elevated confidence. Modafinil can also help control the stress and can help reduce the symptoms of anxiety.

In the US, Provigil is also being used in treating atypical depression. This medical condition is noticeable in over-eating, hypersomnia, rejection sensitivity and low energy. Although as these are all off-label use cases, studies need to be performed so the FDA approve the use and dose required for treating such symptoms and conditions.

A good number of patients have found success taking Modafinil as a treatment for weight loss. Modafinil can result in advanced caloric expenditure and it can reduce the appetite by almost 38% less calories per day. Despite being used for many off-label purposes, it’s primary use continues to be that of a temporary cognitive enhancing agent.

A single dosage of Modafinil in the morning can give individuals a very sharp focus and eliminate urges for procrastination. To counter the effects of fatigue, the US Air Force has approved Modafinil to be used to increase alertness in personnel. Infact the late-founder of the company himself stated that Modafinil can be used as a alternative to coffee or amphetamine like substances when asked, “What else can this novel molecule be used for?” the CEO said.

Modafinil Dosage

provigil 50mg
Sample size of 31 patients consuming Provigil showed that 200mg followed by 50mg are the most common dose’s. Patients decided to go against mentioning if they had any condition, symptoms they were taking it for and it’s perceived effectiveness. We will be releasing a graph that will let us know the intent based on type of stack made, based on manually checking the stacks, most are for “Cognitive Enhancement”.

What dosage is right for you? Modafinil usually comes in two sizes, 100 mg and 200 mg. It’s the sales of 200mg out rank that of 100mg. For the most part your doctor will prescribe you the right dosage based on any medical conditions you may or may not have. Generally, if being taken for mental alertness, 25mg is a good starting point to determine if the desired effect is felt, if not you can increase your dose the day after. It should not matter if you are taking it on empty stomach or not. One easy way to tell if you have taken too much is a headache.

modafinil half life doseThe usual recommended dosage of Modafinil is 200mg, that is once in day often in the morning, some people claim it takes up to 3 hours to “kick in” (see graph below) and thus it may be advisable to take right upon waking as you will feel alert by the time you get to work.

The Best Modafinil Dose for You

First things first,  Modafinil is not for children, Children shouldn’t take it at all — especially given the disapproval by the FDA based on testing.

If you take Modafinil to counter shift work sleep disorder (Excessive drowsiness as a result of irregular work hours or schedule) then you should consider taking Modafinil just one to three hour right before the shift begins. Thus if you’re working for 8 hours, and even if the drug takes 2 hours to come into effect, based on the graph on the left you can see that the concentration in your blood remains high enough for you to get through your work effectively.

Some believe that Modafinil needs to be taken as per the body weight; however, only little evidence was there to prove that Modafinil is necessary only for an average user. Every supplement or drug has it’s pros and cons, a risk-reward ratio, and Modafinil is no different. Although Modafinil is considered to be a safe drug to take, few possible side effects may be associated when taken. Side effects such as nausea, nervousness, headaches, insomnia, dizziness, anxiety, back pain, rhinitis and diarrhea.

In placebo controlled studies, 8% of the individuals had to discontinue the drug due to adverse side effects. The most commonly noted side effect was headache. Patients on our site have noted that lowering the dosage and then taking it over 2 sessions reduced or removed headaches.  Please consult your doctor or a healthcare professional if any side effects do come up. When you have decided to take the drug start with small dose and observe for a week . If there are no negative effects you could increase the dosage. You can also learn more about Modafinils successor, Armodafinil, or Nuvigil here.

References

https://trackmystack.com/supplements-Modafinil-(Provigil)#experiences
http://www.ncbi.nlm.nih.gov/pubmed/24247883

The 5 Best and Most Popular Smart Drugs

smart drugsWith the arrival of the movie Limitless featuring a fictitious drug known as NZT-48 which exponentially improves human cognitive function beyond its present constraints, more individuals started toying with the possibility of a medication which could make them more intelligent. In spite of the fact that it sounds like a dream, researchers all over the globe have been attempting to create brain enhancing medication which can do just that.

As of this day, researchers have not created anything close to NZT, but we do have smart drugs (sometimes colloquially referred to as nootropics or used off-label as ‘smart drugs’) which we can use to enhance our focus temporarily in meaningful ways. Smart Drugs are being utilized far and wide by entrepreneurs, athletes, students, housewives, and poker players. They are utilized to enhance learning capacity, improve concentration and focus, enhance memory function, and written and verbal communication skills.

Not all who utilizes smart drugs will admit it; however, a recent survey done last January 2013, conducted by the prestigious science publication, Nature discovered widespread use. No less than one out of each five individuals surveyed reported utilizing drugs for “non-therapeutic reasons” with a specific end goal to enhance their memory, concentration, and focus. This article focuses on five of the most well-known smart drugs and compare their advantages, effects, negative effects, cost, and availability.

Prescription Smart Drugs

A difference amongst non-prescription and prescription medications is the potential they have for risk factors, including serious negative effects, and addiction. Prescription drugs are classified by the government in schedules as indicated by potential for abuse or addiction. In the realm of ‘smart drugs’, prescription medications such as Dexedrine, Ritalin, and Adderall have previously been widely used and reported.

These three medications are basic psychostimulants utilized fundamentally to improve concentration and focus for those who suffering from attention-deficit hyperactivity disorder and Attention deficit disorder. They provide tremendous value for certain patients, yet are not considered as the best all-around nootropic or smart drugs for improving cognition (for one because they are stimulants and not necessarily helping you heal or cure anything).

Modafinil a physician recommended drug used primarily to treat sleeping disorders such as narcolepsy, however, it continues to grow in popularity with sales figures now exploding primarily for off-label use such as cognitive enhancement1. It is a one of a kind drug that effectively functions to enhance a person’s wakefulness and belongs to a class of medications known as eugeroics.

Modafinil’s prevalence among nootropic users has earned it a spot in mainstream publications such as The Atlantic and Rolling Stone, CNN and ABC among others. Patients have reported that Modafinil not only gives them a feeling of mental alertness, but also enhances focus, motivation, and concentration. For some, efficiency increases, projects get completed start-to-finish, and remaining focused get’s much easier and starts to feel like the new norm. Almost sounds like a magical drug, we will explore its side effects and cost down the line below to provide a full picture of this drug:

  • It likely increases the user’s tolerance (an insensitivity to the medication) over time.
  • It can only be purchased with a prescription.
  • The costs of Modafinil, if not covered by insurance, can be over the top. For instance, the normal expense for a 30-day supply of generic Modafinil (30 pills) ranges between $550-$900.
  • Its potential negative effects which may exceed the benefits for a few clients, as it increases heart rate, anecdotal evidence points to getting agitated easily.

Because of these reasons, numerous smart drug clients choose to utilize a non-prescription based smart drug known as Adrafinil, which is the precursor to Modafinil.

What is Adrafinil?

smart pillsAdrafinil is a type of Nootropic drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. The reason behind this is that Adrafinil is legal in many places such as United States and has the ability to convert into Modafinil in the liver.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.

Noopept

Noopept is nootropic supplement that is used to enhance learning capacity, memory, and concentration. It is known to be one of the most effective of all Nootropic supplements available on the market today.

What are the benefits of Noopept?

This supplement provides numerous benefits that affect the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. All of these actions combined are the reasons for the wide range of health benefits of this Nootropic drug.

The best known benefit of using this drug is that it significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, improved mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and improved thinking. You can compare it modafinil vs noopept here.

Choline

Choline is a substance that can be found in small amounts in various types of food products that we consume every day such as eggs. Choline functions as a direct precursor for the production of acetylcholine and it ensures that our body has adequate amounts of it.

What are the benefits of Choline?

Studies indicate that choline could enhance the effects of nootropic drugs, think of it a compound that strengthens the connections between neurons in the brain. Headaches are reported as the common side effect following the intake of nootropic drugs such as noopept or a racetam and consuming adequate amounts of Choline could relieve headaches. There are different supplements for choline such as: Choline Bitartrate, Alpha GPC, and Citi Choline.

Pramiracetam

A compound similar to Piracetam but considered much more potent. It works by binding to Acetylcholine receptor sites and then blocking their desensitization in order to increase the action potential of the neurons. Since it is very similar to the other Racetams, these comparisons may be worth looking at: Pramiracetam vs Piracetam, Pramiracetam versus Phenylpiracetam, and Pramiracetam vs. Oxiracetam. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

The Best Cognitive Enhancer or Smart Drug?

best smart drugsThese smart drugs are the most popular because of the fact that their advantages are easy to notice, some are very accessible in terms of price and availability. Each individual’s neurochemistry is distinctive, medicines and supplements may influence every individual in different way.

Among these five most well-known smart drugs, Piracetam is the oldest and safest and is the most well known cognitive booster. Numerous individuals start off with a Piracetam only stack and continue using it, failing to veer away. Others may add Citicoline or Alpha-GPC for synergistic reasons. It may be a slight process of trial-and-error or “biohacking” to determine the perfect dose and supplement/drug that works best for you, and remember to always consult with a professional before starting.

References:
¹ https://www.drugs.com/stats/provigil

Top 10 Most Effective Nootropic Supplements

nootropic supplementsWhat are the most effective nootropics that you can try? Nootropic supplements are also known as brain boosters and cognitive enhancers because of their ability to enhance mental performance and produce various positive effects to the brain. This includes improved speed of recall, heightened mental energy, improved short-term and long-term memory, enhanced mental clarity, and improved concentration.

These supplements may also improve the communication between neurons, thus enhancing their overall effectiveness and could promote a much healthier brain. This leads to better executive function, enhanced fluid intelligence, even more creative thought, and improved problem-solving. This means not all nootropics are taken “when you need a boost” but can be taken as a “vitamin” for neuroprotective reasons as well, think about it, if you can take a supplement for your body, why not to a larger extent for your brain as well.

There are a lot of clinical cases where some of these nootropics have helped and they include: attention deficit hyperactivity disorder (or ADHD), Parkinson’s disease, dementia, Alzheimer’s disease, as well as age specific cognitive decline. These benefits are the reason nootropics are being widely used by many people, for some, many times throughout the day. Below we list our top 10 supplements (& drugs) that may be of use to you. CONSULT YOUR HEALTH CARE PROVIDER BEFORE STARTING A REGIMEN WITH THESE. Consider this article a guide for beginners to get know about what’s out there and what their functions are.

There are many types of supplements available and this may be overwhelming for those looking to start. We wanted to make it easier by listing the top nootropic supplements in order of  most potent and most effective nootropics to “least” in our top 10. Least is in quotes because different supplements provide different benefits and have different side effects. By no means is this list comprehensive.

Modafinil

What is it? Modafinil is a smart drug that enhances energy levels and alertness – particularly in individuals who do not usually get enough sleep. User reports suggest that it gives them the desired mental energy boost that they need better than caffeine and other stimulants do. Hence, it has gotten to be well known for off-label use as a focus enhancer. Modafinil is clinically prescribed for individuals who suffer from sleep disorders such as obstructive sleep apnea, narcolepsy, among other sleep related conditions.

What are the benefits of Modafinil?

Modafinil has appeared to help individuals stay alert and focused, and additionally clear their mind, if they lack sleep or are sleepy. Researchers have effectively demonstrated a relationship between the utilization of this medication and retaining intellectual capacity in a sound state against variables such as absence of sleep. Be that as it may, not every one of them could associate Modafinil to a change in psychomotor capacity in human test subjects.

Regardless of its beneficial outcomes on concentration enhancement, focus and short-term memory, it hasn’t demonstrated huge enhancements in cases that concerned healthy adults with attention deficit hyperactivity disorder (or ADHD). Then again, the same condition found in kids appeared to benefit from the utilization of Modafinil to the same or more prominent degree as methylphenidate, the prescribed medication of choice for that purpose.

Noopept

What is it?

Noopept is primarily used to enhance learning capacity, memory, and concentration. It is known to be one of the more potent cognitive enhancers and considered to be much more effective than most other synthetic nootropics especially when compared to other racetams.

What are the benefits of Noopept?

This supplement provides numerous benefits related to the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. It is thought that these combined actions are the reason for the wide range of cognitive benefits.

The most well-known benefit of this drug is it’s ability to significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, better mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and logic processing.

Adrafinil

What is it?

Adrafinil is a drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. While as Modafinil is a controlled substance, Adrafinil is not, it metabolizes in the liver to form Modafinil. It can be a bit harsh on the liver for this very reason, so it is not advised to supplement this drug frequently and if done so, your liver enzyme levels should be monitored closely.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.

Pramiracetam

What is it?

Pramiracetam is an “advanced version” of Piracetam, it’s mechanisms of action too is very similar, it includes binding to Acetylcholine receptor sites in the brain and inhibiting their desensitization in order to increase the action potential of the neurons. Pramiracetam is one of the most powerful Nootropic supplements available. It has a very high bioavailability and is a fat soluble racetam and is noted to have long half-life.

What are the benefits of Pramiracetam?

Pramiracetam is known to be one of the “purer” Nootropics. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

Phenylpiracetam

What is it?

Like pramiracetam, phenylpiracetam is also an “advanced and stronger” version of Piracetam. It contains a Phenyl molecule group attached to the original Piracetam and is known to be 60x more concentrated. This is why Phenylpiracetam provides better benefits may be a considered a step up from Piracetam.

What are the benefits of Phenylpiracetam?

Phenylpiracetam is known by its ability to help improve general tolerance to stress and cold. According to its user reviews, Phenylpiracetam could increase a person’s memory, focus, learning capacity, concentration, attention span, as well as mental energy. Additionally, it helps enhance physical performance, promotes intense focus, and improve workout recovery times.

Sulbutiamine

effective nootropic supplementsWhat is it?

Sulbutiamine was originally synthesized in Japan, it is a synthetic version of Thiamine (or Vitamin B1) and is primarily used to enhance the overall energy levels of the brain. Sulbutiamine is not really considered a “true” Nootropic; however, it seems to go very well with other supplements that is why it is commonly stacked as part of a larger nootropic regimen.

What are the benefits of Sulbutiamine?

Sulbutiamine helps a person relax and promotes a feeling of general well-being. It improves the ability to concentrate and focus as well as enhancing attention span.

Aniracetam

What is it?

Aniracetam belongs to the Ampakine family and is considered as a Racetam. It has the ability to provide mood boosting effects and reduces the levels of anxiety and stress and thus it is known as a potent anxiolytic. Aniracetam could greatly benefit those who suffer from depression, social anxiety, and other mood disorders.

What are the benefits of Aniracetam?

Some of the benefits of Aniracetam include improving focus, memory, and attention span. Aniracetam is not considered a CNS stimulant. However as a user it’s common to experience a initial boost of energy followed by feelings of relaxation. It is said this nootropic also increases memory Input and Output (I/O reference: Dave Asprey), meaning it helps with recall and speech fluency, however consider this anecdotal.

Huperzine A

What is it and what are its benefits?

Huperzine A is a herbal nootropic that is widely used by people for it’s ability to help inhibit an enzyme that degrades the learning neurotransmitter, acetylcholine. It is derived from a plant called Huperzia Serrata, which is abundant in China. Acetylcholine is one of the most important neurotransmitters in our body as it helps improve numerous cognitive functions and processes and enhances memory.

5-HTP

What is it and how does it work?

5-HTP is a chemical that is synthesized in the human body via L-Tryptophan and is converted into Serotonin inside the brain. Like acetylcholine, serotonin is also among the most important neurotransmitters since it is also responsible in promoting normal sleep patterns and regulates mood. It could also prevent over excitation of the brain and helps with better focus.

Choline

What is it?

Choline is a substance that can be found in small amounts in various types of food products that we consume every day. It is one of the basic components for any nootropic/cognitive enhancement supplement stack. Choline sources such as Choline Bitartrate, or CDP Choline function as a direct precursor for the production of Acetylcholine, thus it is important to supplement or consume it via food to make sure you have adequate levels.

What are the benefits of Choline?

Some studies show that choline could better potentiate the effectiveness of various nootropic drugs. Headache are considered to be a common side effect following the intake of racetams, a depletion of choline could be the culprit. Although it really does depends on your own biology, as it could be many other factors. Many will have you believe that you must supplement choline with any racetam and that is simply not the case. It should be consumed “as needed”, a little trial and error will you determine the right dose, but stay within the suggested dose on the label.

Based on TrackMyStack Users

Our users are taking the following nootropic supplements for cognitive enhancement, this report is updated live and can be accessed here to view the live version.
nootropic supplement report

Gender breakdown of the above report:

nootropic report by gender

 

References:

  1. http://www.drugs.com/cdi/modafinil.html
  2. https://en.wikipedia.org/wiki/Adrafinil
  3. https://en.wikipedia.org/wiki/Phenylpiracetam
  4. https://examine.com/supplements/sulbutiamine/
  5. https://www.smartdrugsforthought.com/what-is-aniracetam/
  6. http://www.webmd.com/vitamins-supplements/ingredientmono-764-huperzine%20a.aspx?activeingredientid=764&activeingredientname=huperzine%20a
  7. http://www.everydayhealth.com/drugs/5-htp-5-hydroxytryptophan
  8. http://www.webmd.com/vitamins-supplements/ingredientmono-436-choline.aspx?activeingredientid=436&

Limitless Drug NZT-48

The Real Limitless Drugreal limitless pill

The film Limitless, which stars Bradley Cooper, Arbie Cornish, and Robert Deniro, has made a huge impact on society. This is mainly because it revolves around mental capabilities and how we could unlock our full potential just by taking a single pill- the NZT 48 drug.

What is NZT?

In the film, NZT-48 is such a powerful drug that it makes Bradley Cooper, known as Eddie Mora in the movie, unlock his full potential. He is superhuman when he takes the pill; not only is he able to use 20% of his brain’s capacity, but he is able to go much beyond that.

In  reality, we use 100% of our brain, not all the time, but we use different parts of our brain for different things, the 20% of our brain usage is a urban myth. Anyways Bradley becomes the smartest living creature, doesn’t run out of energy, is able to learn languages and make a lot of money in the stock market. Would this be something you would take?

Does NZT48 really exist? The truth is, NZT-48 is just a creation of fiction and it was created to sell the movie. So the question is, why do we have the need to talk about this topic? Does it only give us a dream, or a false hope of using our brain’s potential 100% of the time? Even though NZT-48 is not real, there’s supplements and drugs referred to as Nootropics and they are starting to appear promising.

What are Nootropics and are they close to NZT?

By definition, nootropics are drugs that can protect your brain, enhance memory and/or other cognitive functions. They serve to promote enhancement in memory and facilitation of learning (1). Among the most famous nootropics today is the Racetam family and the first nootropic drug to be used widely was Piracetam, a synthetic derivative of GABA, also known as aminobutyric acid. You don’t need to remember this, although if you were on it, it wouldn’t be hard..would it?

Although its mechanism of action is still not fully understood, studies show that Piracetam positively affects the release of neurotransmitters in our brain and their receptor-binding capabilities. This improves cell functioning and leads to cognitive enhancements such as more efficient and easier memory formation, and memory recall. Also, Piracetam is involved in the activation of Acetylcholine, an important neurotransmitter in the brain related to memory processes and development (2). It is fairly easy to buy online as well and is considered safer than table salt (when you look at the LD50).

At present, various nootropics have already been discovered; these are much more potent than the parent compound Pireacetam. These smart drugs have a wider array of cognitive benefits and improve other areas like mood, behaviour, energy, and others. One such smart drug is Noopept — it is believed to be 1000x more potent than its derivative Piracetam. Other familiar nootropics also include Phenylpiracetam– also a derivative of Piracetam and is believed to be 30-60x more potent than its parent compound Piracetam.

One notable feature is that it has a phenyl ring added to the original structure, giving it a higher affinity for Norepinephrine and Dopamine, and making it easier to cross the Blood-Brain Barrier or BBB. Moreover, it enhances physical performance and gives stimulating and energizing effects through an increase in Noradrenaline levels.

Although athletes find this very useful, it is banned in the Olympics due to its psychostimulatory and cold resistance properties. Phenylpiracetam also has the ability to motivate and reduce the effects of anxiety and stress. Finally, other various smart drugs known in the market today include Pramiracetam, Aniracetam, Alpha GPC, Citicoline, Phenibut, and many more.

Through gradual research and experiment, a lot of smart drugs today show a large resemblance to NZT-48. The above are marketed as supplements but the FDA would not classify them as supplements. There are some drugs that are approved by the FDA (in America, it is the regulatory agency, and we will talk about that below).

Is Modafinil the original limitless pill?

modafinil limitless review

Is modafinil really the original nzt48 pill? Consider Adrafinil, as the legal limitless pill and is available for sale online. Is it also a fictional drug like the NZT-48? Well here is the good news, Modafinil in contrast with NZT48, is a real-life drug. Yes you heard it right, Modafinil is not just available on our television screens, but we can actually buy it. But how is Modafinil related to the limitless pill NZT-48? Modafinil was actually the inspiration for NZT-48. It is used as a wakefulness-promoting agent primarily used to treat Narcolepsy (a condition causing excessive daytime sleepiness), shift work sleep disorder, and other sleep disorders.

Its wakefulness-promoting properties and increase in energy levels may be attributed its role as an adrenergic receptor agonist. It activates orexins/hypocretins (these are brain peptides) thus, increasing dopamine, norepinephrine and histamine levels. Moreover, Modafinil serves to improve memory and brain function through enhanced neuronal stimulation; more specifically, positive stimulation of Glutamate receptors and inhibition of Glutamate breakdown.

Because of Modafinil’s mechanism of action, it is the drug that is the closest thing to limitless pill NZT 48. Soon we will also review Donepezil which many now consider a limitless like pill as well. Modafinil is obviously a prescription drug and there can be many side effects, however with a good diet and proper nootropic supplementation you can ‘generally’ always feel noticeably smarter than your baseline, it is like body building, you can take supplements to go from your baseline to your absolute genetic potential but then as bodybuilders take steroids, drugs like modafinil can be used to push the brain to it’s capacity and thus we don’t recommend anyone try it right off the bat, especially not without consulting a physician.

Conclusion

Although NZT-48 may just be a fictional drug–the idea is real, there are a lot of promising smart drugs in the market that offer similar benefits. One supplement may provide benefits in one facet, but when stacked with others may be the complete regimen you need to feel more intelligent. We urge you to browse different stacks and see the results people are getting. A popular example of stacking is the combination of Racetams with Cholinergics.

For instance, the actions of racetams are attenuated due to an increased level of neurotransmitters that are essential for brain functioning. Be sure to track your results over time to see how the changes are affecting you. If you would like to skip nootropics and go straight to a nzt like smart drug consider buying adrafinil (modafinil precursor) here.

 

References:

  • http://www.merriam-webster.com/medical/nootropic
  • https://smartdrugsforthought.com/what-is-piracetam/

 

Guide to Provigil Abuse, Addiction and Withdrawal

Modafinil Provigil

Disclaimer: The below article is a guestpost by Ash Sharman (A nootropic enthusiast, who has submitted a few more articles to be posted on the topics of nootropics to us) and thus are not the views of Track My Stack.

Provigil, popularly known by its generic name Modafinil, is a smart drug used for enhancing mental performance, reasoning and learning. It is used for improving wakefulness in adults. Many adults experience excessive sleepiness because of sleep apnea, shift work sleep disorder or narcolepsy.

Researchers are not sure how Modafinil promotes wakefulness. One hypothesis is that it may increase dopamine levels in the brain by obstructing the reuptake of dopamine, a neurotransmitter that regulates the chemical signals from one nerve cell to another. The Food and Drug Administration (FDA) approved this drug for the cure of narcolepsy in 1998. It also approved its use for shift work sleep disorder and obstructive sleep apnea in 2003.

Top Reasons for taking Provigil/Modafinil as a smart drug:

Provigil has been portrayed as a magic pill. When consumed, it makes a person feel more eloquent and better equipped to perform complex and demanding mental tasks. It is popularly used in college campuses and high-stress profession that requires focus and attention to details. This is why it is common to find it on Wallstreet (in Finance) or in a developer’s (Programmers) medicine cabinet. You will enjoy hours of unshakable concentration for up to 15 hours after taking a single dose of up to 200mg. However, it is no adderall, it will keep you from feeling tired/sleepy/groggy which will allow you to keep focused. As the “fame and excitement” of this smart wonder drug is on the rise, fears about its abuse, addiction and withdraw dangers also takes the central stage.

Some call Provigil a “Super Drug” as sometimes it is used for performance enhancement by military fighter pilots and soldiers during combat situations. It also enhances short-term memory allowing the users to remain awake for longer periods.

What are the key things you need to know about Provigil?

Provigil is a federally controlled drug and should be used as per the direction of a GP. You should store it in a safe place to prevent abuse or misuse. It is against the law to sell this drug to another person. The drug is not approved for use in children for any medical condition. And, it is still unknown whether it’s safe or works for children under the age of 17 or not. Individuals that show signs of sleep apnea use this drug in combination with other medical treatments.

Provigil can lead to grave side effects including a serious rash or an allergic reaction affecting your liver and blood cells. The side effects are life-threatening and require medical treatment. You must stop taking the drug immediately and seek medical help if you develop a skin rash, blisters, rashes, yellowing of the skin, dark urine or have trouble swallowing or breathing.

Basic dosages for Provigil

Provigil comes in two strengths, 100 mg and 200mg. It is generally taken during morning hours to prevent daytime sleepiness or one hour before the start of a work shift. If you consume too much Provigil, you will experience nausea, diarrhea, confusion and (obviously) have trouble sleeping.

Consequences of Provigil withdrawal

People who have used Provigil for the long term and stopped did not show any physical withdrawal issues.  It is assumed Provigil gets its effect by releasing CNS histamines in the brain. These agents create targeted stimulation of neurotransmitters which causes Provigil’s effects of wakefulness and alertness. You may experience a headache with Provigil/Modafinil use which may require you to consume a lot more fluid/or food as your appetite may get suppressed without you noticing it. It could also be because your dose may be too high to start and other users have said choline/uridine MAY help. Everyone’s biology is different, stop use if the headaches don’t subside.

Ways to avoid Provigil abuse, addiction and withdrawal dangers

If you fear of any Provigil abuse, or have any history of substance abuse, it is good to take some other natural nootropics that present less issues. Keep in mind, Modafinil isn’t necessarily addictive per say. If you do start taking Modafinil consider using our platform as a medication tracker tool to make sure you have no negative interactions, your dosing correctly and to get general feedback from our users.

It is important to be little careful while using Provigil as some of its side effects can be very serious (even though they affect a very very small percentage of the population). It should not be used without prior consultation of doctor in any case if possible. Feel free to also browse around our site and explore stacks for nootropics to see what others are taking.