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The 5 Best and Most Popular Smart Drugs

smart drugsWith the arrival of the movie Limitless featuring a fictitious drug known as NZT-48 which exponentially improves human cognitive function beyond its present constraints, more individuals started toying with the possibility of a medication which could make them more intelligent. In spite of the fact that it sounds like a dream, researchers all over the globe have been attempting to create brain enhancing medication which can do just that.

As of this day, researchers have not created anything close to NZT, but we do have smart drugs (sometimes colloquially referred to as nootropics or used off-label as ‘smart drugs’) which we can use to enhance our focus temporarily in meaningful ways. Smart Drugs are being utilized far and wide by entrepreneurs, athletes, students, housewives, and poker players. They are utilized to enhance learning capacity, improve concentration and focus, enhance memory function, and written and verbal communication skills.

Not all who utilizes smart drugs will admit it; however, a recent survey done last January 2013, conducted by the prestigious science publication, Nature discovered widespread use. No less than one out of each five individuals surveyed reported utilizing drugs for “non-therapeutic reasons” with a specific end goal to enhance their memory, concentration, and focus. This article focuses on five of the most well-known smart drugs and compare their advantages, effects, negative effects, cost, and availability.

Prescription Smart Drugs

A difference amongst non-prescription and prescription medications is the potential they have for risk factors, including serious negative effects, and addiction. Prescription drugs are classified by the government in schedules as indicated by potential for abuse or addiction. In the realm of ‘smart drugs’, prescription medications such as Dexedrine, Ritalin, and Adderall have previously been widely used and reported.

These three medications are basic psychostimulants utilized fundamentally to improve concentration and focus for those who suffering from attention-deficit hyperactivity disorder and Attention deficit disorder. They provide tremendous value for certain patients, yet are not considered as the best all-around nootropic or smart drugs for improving cognition (for one because they are stimulants and not necessarily helping you heal or cure anything).

Modafinil a physician recommended drug used primarily to treat sleeping disorders such as narcolepsy, however, it continues to grow in popularity with sales figures now exploding primarily for off-label use such as cognitive enhancement1. It is a one of a kind drug that effectively functions to enhance a person’s wakefulness and belongs to a class of medications known as eugeroics.

Modafinil’s prevalence among nootropic users has earned it a spot in mainstream publications such as The Atlantic and Rolling Stone, CNN and ABC among others. Patients have reported that Modafinil not only gives them a feeling of mental alertness, but also enhances focus, motivation, and concentration. For some, efficiency increases, projects get completed start-to-finish, and remaining focused get’s much easier and starts to feel like the new norm. Almost sounds like a magical drug, we will explore its side effects and cost down the line below to provide a full picture of this drug:

  • It likely increases the user’s tolerance (an insensitivity to the medication) over time.
  • It can only be purchased with a prescription.
  • The costs of Modafinil, if not covered by insurance, can be over the top. For instance, the normal expense for a 30-day supply of generic Modafinil (30 pills) ranges between $550-$900.
  • Its potential negative effects which may exceed the benefits for a few clients, as it increases heart rate, anecdotal evidence points to getting agitated easily.

Because of these reasons, numerous smart drug clients choose to utilize a non-prescription based smart drug known as Adrafinil, which is the precursor to Modafinil.

What is Adrafinil?

smart pillsAdrafinil is a type of Nootropic drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. The reason behind this is that Adrafinil is legal in many places such as United States and has the ability to convert into Modafinil in the liver.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.


Noopept is nootropic supplement that is used to enhance learning capacity, memory, and concentration. It is known to be one of the most effective of all Nootropic supplements available on the market today.

What are the benefits of Noopept?

This supplement provides numerous benefits that affect the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. All of these actions combined are the reasons for the wide range of health benefits of this Nootropic drug.

The best known benefit of using this drug is that it significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, improved mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and improved thinking. You can compare it modafinil vs noopept here.


Choline is a substance that can be found in small amounts in various types of food products that we consume every day such as eggs. Choline functions as a direct precursor for the production of acetylcholine and it ensures that our body has adequate amounts of it.

What are the benefits of Choline?

Studies indicate that choline could enhance the effects of nootropic drugs, think of it a compound that strengthens the connections between neurons in the brain. Headaches are reported as the common side effect following the intake of nootropic drugs such as noopept or a racetam and consuming adequate amounts of Choline could relieve headaches. There are different supplements for choline such as: Choline Bitartrate, Alpha GPC, and Citi Choline.


A compound similar to Piracetam but considered much more potent. It works by binding to Acetylcholine receptor sites and then blocking their desensitization in order to increase the action potential of the neurons. Since it is very similar to the other Racetams, these comparisons may be worth looking at: Pramiracetam vs Piracetam, Pramiracetam versus Phenylpiracetam, and Pramiracetam vs. Oxiracetam. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

The Best Cognitive Enhancer or Smart Drug?

best smart drugsThese smart drugs are the most popular because of the fact that their advantages are easy to notice, some are very accessible in terms of price and availability. Each individual’s neurochemistry is distinctive, medicines and supplements may influence every individual in different way.

Among these five most well-known smart drugs, Piracetam is the oldest and safest and is the most well known cognitive booster. Numerous individuals start off with a Piracetam only stack and continue using it, failing to veer away. Others may add Citicoline or Alpha-GPC for synergistic reasons. It may be a slight process of trial-and-error or “biohacking” to determine the perfect dose and supplement/drug that works best for you, and remember to always consult with a professional before starting.