Skip to main content

Brain Enhancement Supplements

Do Brain enhancement supplements and drugs actually work?
Some are risky and are others even worth trying? We will discuss their safety and usefulness.

brain-enhancement-supplementMany bankers, college students and of course the geeks in Silicon Valley are sharpening their minds with the use of cognitive enhancement supplements. The mainstream medical media has renounced cognitive enhancement supplements as nothing but bogus and snake oil being sold to the mass public but is this really true?

Is a cup of Joe just as good as it can get for us or is there something else we can stack along or consume independently that can produce measurable objective results.

To quickly recap we will discuss what brain enhancing drugs are, what smart drugs are, and what nootropics are and what the main differences between these are.

Smart Drugs
Memory enhancing drugs also referred to usually as smart drugs are pharmaceuticals that are prescribed by your primary caregiver most likely a physician. These include drugs such as modafinil which is prescribed for sleep disorders or others for ADHD such as Ritalin and Adderall among others.

Nootropics are loosely defined as substances that help maintain the integrity of your brain and keep your brain functioning at optimal levels using natural or sometimes synthetic compounds that can be consumed for the long run. An example of a nootropic that can be taken for a long time would be Bacopa Monnieri from the Ayurvedic medicine system. These nootropic supplements are largely unregulated and have a lower amount of scientific evidence to back their efficacy, however as in the case of Bacopa, they have been consumed for over 2,500 years.

We will quickly discuss how ADHD medications work and we will discuss which nootropics you should consider taking. ADHD  drugs are useful for those that have attention issues (obviously), poor memory and mood swings. These drugs are essentially a legal form of amphetamines, they have slow release and are a combination of different salts1. Overtime these drugs have been reported to have many side effects and dependency issues and worst of all produce a tolerance build up, because of these said reasons, those suffering from cognitive issues consider natural alternatives first.

What are Nootropics?

One of the original nootropics supplements is called Piracetam. It is quite possibly the most well known and most will research among all the other racetams. It Is widely used in college campuses around America, and it was discovered by the same people that coined the term nootropics. Piracetam at one point was also sold as a commercial pharmaceutical drug named Nootropil. Many more derivatives of Piracetam have been developed and are much more potent but lack the clinical research, one such drug is called Noopept, which is claimed to be 1000x more potent — were not sure how that measure of potency came to be.

lumonol reviewAnother example of a natural nootropic as stated earlier is Bacopa Monnieri. Bacopa increases BDNF when supplemented for at least 30 days which means the connections between neurons is strengthened thus providing better memory supposedly in trials2. There are countless other natural cognitive enhancers that you can explore over here. Another supplement that we highly recommend is  Lumonol, and you may read the review for Lumonol and its positive effects on users on the review page. It contains Noopept and a wide gamut of many other supplements that help improve memory and recall in the short and long-term.

Off-Label Smart Drugs

An example of an off label smart drug being utilized for cognitive enhancement includes one called Armodafinil or its predecessor Modafinil. Generally this drug is only approved for uses of sleep work disorder, sleep apnea and narcolepsy. If you were to read online forums, you would notice that everyone says modafinil is completely safe to use for the long term without worry. However, many side effects have been reported, with headaches being by far the biggest side effect. Some side effects that we noticed our self from testing it was anxiety, irritability and slight dizziness the day after. Also, a decreased appetite, though that can be seen as a positive effect as weight loss is a benefit in many people’s eyes. This drug is sold under many brand names such as: Provigil, modalert, and alertec. You can actually even buy it online under it’s “less purified form” called Adrafinil which we also have reviewed.

Disclaimer: Warning and Safety of Brain Enhancement Supplements

Generally if you feel that you’re already performing at your peak you need not try any of these supplements or drugs.

If you feel like there’s room for improvement and you have felt better before, you could give it a try, it is advisable that you talk to your doctor first before starting and do thorough research before building your stack. Generally the greatest impact will occur for those actually suffering from cognitive deficits. If you do not notice any significant improvements then you may just be performing at your peak or the the supplements you have decided just may not be working for you.

To know for sure we advise you to use our site to measure your results, keep everything equal, and change one variable at a time, it will pay off in the long run. If you are under the age of 18, think twice before attempting to bioengineer yourself through chemistry. Make sure you’re taking the obvious supplements first, such as a vitamin B complex (perhaps stacked with Choline), which alone may be enough for you. Additionally make sure you get enough sleep, and that you are eating healthy, not consuming copious amounts of alcohol and exercising to make sure these items are not impacting your cognitive performance before beginning a supplement regimen. Good Luck.

Nutrition Tracker

A Free Nutrition Tracker

TrackMyStack is slowly morphing in it’s abilities to track everything you may need to, to feel your optimal self. The newest feature we have been working on diligently is a nutrient tracker. Our platform will help you keep a log of your nutrition, and count your daily intake of calories, fat, protein and carbs. We intelligently plug into a database of food recipes/nutrition database so for many items of food you are not required to enter any values. Below is a breakdown of everything this nutrition software will help you do.

  1. Daily Nutrition Tracker – you can log as many entries as you need to daily, just enter a food and we do our best to guess what you are talking about and try to pre-populate the macronutrients. Soon we will allow you to mark each entry as “clean”, “gluten free”, “grass fed”, etc. as well.
  2. Track Vitamins – Along with tracking your macros, you have an additional detailed ability to record exactly which supplements and brands you are currently taking to determine and make sure you are reaching all RDA’s
  3. Free Nutrition Software – best of all, all of these features are available to you free of charge even with a basic account, however previewing graphs of food requires a Pro account.
  4. Discover Triggers – now you can cross reference your diet to your mood, medicine intake, symptoms, and pain. Additionally you can track your exercise, and symptoms, mood and sleep as well.

Nutrition Tracking App

See these screenshots below to see if our platform can be a good substitute for a traditional printable nutrition log. We will continue to add features and capabilities to really personalize everything as time goes on to be the best nutrition tracker out there. For now we demonstrate how to track your meals daily:

add nutrition to log
Step 1. Quickly enter any food item that you have consumed and want to log. This is the first step in recording your nutrition daily.


daily nutrition
Step 2. A list of most common entries will be provided where you may quickly choose one or continue to add your own original nutrient values.


macronutrient breakdown of eggs
Step 3. Once a food is selected, all nutritional values for that food are automatically presented to you, making tracking nutrition that much easier. You are free to edit and add weight, protein, sugar, calories, fat, and carbs.


Step 4. You may add multiple items in one journal check-in. In this example we added bacon and eggs. Any values at this point can not be edited but deleted only. As more users use our software we will build up a more comprehensive database of foods available to be tracked.


The Final Step. After your entries have been made and you have added the right calories and adjusted your totals, you can view it on your stack page. Additionally by the time you read this we should also have graphing capabilities where you can view your intake over time and find patterns that may emerge that may help you maintain a balanced diet.

More Than A Calorie Counter App

Counting your calories, and keeping a nutrition log online has many other benefits such as being able to log the entries from wherever you are via your phone. Proper nutrition tracking will help you either lose weight, eat healthy, or gain muscle, depending on your goal. The benefit of using our app over the countless others such as myfitnesspal for example is that health & wellness is a bit more than tracking your calories, the data that can be analyzed using the various other trackers we have truly gives you a complete picture of your health. Being able to see what other’s are doing for their health goal, viewing their reports, ability to see which supplements work and do not (backed by science), adding symptoms and conditions and the ability to set-up reminders (adherence notifications, caregiver notifications) are just a few of the countless things we do that other tracker can’t. The fact that we go above and beyond in what you can track but don’t explicitly require all the data is what we think makes us the best weight loss app or calorie calculator out there.

Getting Started with our Nutrition Tracker

To get started using our nutrient counter for free, you can create a stack here, it is free to signup and get started. If you have any other questions on how to track nutrition or any feature requests, feel free to contact us.

What are the Best Racetams?

racetamsRacetams, the colloquial name for a group of structurally identical nootropic chemicals ending with … “racetams”. We regard them on our site as supplements but they indeed are drugs.

The invention of the Racetam family of drugs happened accidentally. As Racetams were not being formulated as mental enhancers but designed as a cure for motion sickness.  Unanticipated discoveries similar to this are widespread in pharmacology.

The most famous Racetam is called Piracetam, others include:  Aniracetam, Oxiracetam and Pramiracetam possess a 2-pyrrolidine nucleus comprised of nitrogen , oxygen and hydrogen.

Learning improvements, enhanced memory and focus, elevated mood and high energy levels are some of the effects of Racetams. Stimulation of cholinergic receptors of the neurotransmitter acetylcholine is the mainstay of mechanism of Racetams. These also boost glutamate uptake via stimulating AMPA and NMDA receptors.

List of Racetams

About 19 diverse Racetam supplements have been contrived ever since the invention of Piracetam – the first Racetam compound.

The whole list of Racetams include: Aniracetam, Coluracetam, Brivaracetam, Dimiracetam, Fasoracetam, Etiracetam; Imuracetam, Nebracetam, Levetiracetam, Nefiracetam, Oxiracetam, Nicoracetam, Phenylpiracetam, Piracetam, Phenotropil, Pramiracetam, Rolziracetam, Rolipram and Seletracetam.

Most of  these substances are employed for many different health and medicinal purposes but some are commonly employed for use in the form of Nootropics: Piracetam, Oxiracetam, Aniracetam and Pramiracetam.

These four are discussed below to let you learn about which Racetam may be best for you:


Piracetam (known also as Nootropil) is the most commonly used Racetam supplement. It also possesses the privilege of being known as the very first Nootropic ever invented. Piracetam imposes its action via the stimulation of Acetylcholine receptor system leading to the release of neurotransmitters in the brain. Taking piracetam long term will improve brain health and also poses many other benefits in the short term.

Piracetam is more devoid of side effects than a cup of coffee owing to it astonishingly low toxicity profile.

Effects: Piracetam boosted cognitive ability on many metrics immediately. Improved learning and higher memory retention were experienced because of upgraded neuroplasticity. You will readily start to experience higher sensory perception and enhanced awareness. Piracetam also aids in studying and focusing because it heightens motivation and energizes you strongly.

Dosage: About 1.2 to 4.8 grams for 4 times a day is recommended for Piracetam to have noticeable effects according to our users. You can buy 500 g of Piracetam in $39.99, thereby making it affordable compared to other Racetams.

How to Take: Piracetam can be taken in form of powder by making a solution in water and can be combined with any other Nootropics you may want to stack together. Considering stacking with: CDP Choline, Alpha GPC or with any other source of choline as recommended by a physician. Piracetam depletes choline, and that is why having an adequate quantity of choline as part of your diet will help increase neurotransmitter formation.

Centrophenoxine when stacked with Piracetam is known to boost or increase your recall speed – making your mind sharper, highly focused, rather more instantaneous and reflexive when it comes to fact-recall abilities. You can additionally see piracetam alternatives here.


aniracetamAniracetam is a stronger and longer lasting cousin of Piracetam. It is fat soluble and takes a longer time to kick-in. This means you should take it with fish oil or another fatty food source and also realize that it may take longer for the effects to diminish. Aniracetam is a better stimulator of AMPA receptors than Piracetam.

Effects: Aniracetam improves focus along with concentration as it is an AMPA receptor agonist. Aniracetam emerges as one of the best Racetams as well as Nootropics prescribed for studying.

Aniracetam also boosts perception of sound and recognition of colors. It hastens the communication between two brain hemispheres, lessens social anxiety and increases creativity.

Aniracetam Dosage: About 600 to 3000 mg are recommended per day. Most people ought to take Aniracetam  every 4 hours or as required to make sure that the effects last throughout the day. You may get a headache using this Racetam lest you supplement it with choline.

How to Take Aniracetam: The optimal method to take Aniracetam powder is to make a solution in milk for it does not properly dissolve in water. Pure Aniracetam powder can be purchased for $17.99 for every 50 grams. Additionally you buy aniracetam in pill form as well which may make everything easier and as stated can be taken with any fatty food. You can see what other’s are stacking with aniracetam here.


oxiracetamA very potent analog of Piracetam which has swifter mode of action than both Piracetam and Aniracetam. It is in a class of its own as it is more expensive yet, has a smaller dose, yet more expensive than Piracetam.

Oxiracetam is very often used to improve motivation levels and to dismiss the symptoms of mental lethargy and fatigue, but it also comes out to be a cognitive enhancer apart from being a brain booster as many Racetams are popular for.

Effects:  Spatial memory is boosted with Oxiracetam use and learning abstract concepts is improved greatly. Oxiracetam increases choline acetylcholinetranferase levels which is responsible for the acetylcholine neurotransmitter.

ATP levels are increased with Oxiracetam, which provides added energy for harder cognitive tasks. Oxiracetam’s side effects are almost nonexistent, however some individuals report fatigue following longer periods of studying or work during the use of this Nootropic. It is best to consult a physician before starting Oxiracetam.

Dosage:  Oxiracetam dose is suggested at 750 – 1,600 mg a day. Most people should take their dose every 6 to 8 hours during studying or when performing any type of mentally tiring work.

How to Take: Oxiracetam is soluble in water. For ideal results, stack Alpha GPC and Oxiracetam together. You can buy oxiracetam in bulk for the lowest price online here.


pramiracetamPramiracetam has 30x more potency than Piracetam. It is found to be the strongest among all Racetams and has the longest half life as well. These qualities are attributable to the fact that it is soluble in fat and has a greater bio-availability.

Pramiracetam is stacked with other types of Nootropics and Racetams because it is known to greatly enhance the effectiveness of other compounds. More so it’s side effects anecdotally are said to be mild and equivalent to that of table salt.

Effects: Pramiracetam is particularly recognized for boosting mental energy levels and increasing alertness for up to 8 hours following its intake. It makes learning easier by enhancing memory and boosting neuroplasticity.

Dosage: Daily dosage for Pramiracetam is recommended at a much smaller amount for it is highly concentrated. In a 24 hour period between 100 – 1,200 mg of the compound should be taken. Most people will ingest one dose in the morning and a second one early in the afternoon to have the full effectiveness.

How to Take: Pramiracetam is found in white powder form and is soluble in fat. Like many fat soluble Racetams, you should make a solution with milk, not with water or with fish oil or krill oil. Click here to buy pramiracetam in powder or pill form.

To see other nootropic stacks, click here.

Piracetam Headache? How To Avoid this Side Effect

piracetam headachePiracetam is one of the most well researched and original cognitive enhancers. It is a supplement of the Racetam class. It is known to be a very modest neuroprotective and memory-improving agent which offers solid cognitive and neurological benefits, consolidated with essentially non-existing toxicity (less than that of table salt).

A very small percentage of those that use Racetams may experience unpleasant headaches. The headaches caused by Piracetam may last many hours after the initial intake or sometimes it can be very short-lived. Using Piracetam may also intensify migraines and headaches that are caused by some other stimuli.

So, what causes this adverse side effect to occur and what can you could do to avert it from happening to you? Before getting started, let’s see why people take Piracetam:


PROS of Piracetam*

  • Improves Reasoning and Cognition
  • Helps to Support Memory
  • Improves Perception and Alertness
  • Improves Mental Fatigue and Concentration


  • Low Potency Compared to Other Racetams
  • May Cause Headaches in Some Users
  • Long Onset Period of Effects


Why Does Piracetam Cause Headaches?

piracetam headache cureAniracetam, Oxiracetam, Pramiracetam along with Piracetam stimulate the Acetylcholine receptors in the brain. Acetylcholine is possibly the most significant Neurotransmitter responsible for many brain related functions and is also responsible for functions in relation to learning, concentration and reasoning.

Acetylcholine is produced from the food we eat that contains choline, but in so many cases, humans do not get adequate amounts from just food alone. Evidence suggests that taking enough choline with Piracetam, may cause headaches to subside and or be prevented (reference). This is because Piracetam demands a high level of choline be present in our brain when supplemented, without it, your brain will give you a headache. You can think of it as similar to getting a headache from being dehydrated after running, with Piracetam your brain is “running” and choline is the source it needs to keep you going.

The liver makes very little amounts of choline, thus it may be beneficial to buy a choline supplement. Numerous foods contain choline, such as: egg yolks (250mg per egg roughly) and liver meat, regardless of its wide accessibility, scientists think many individuals don’t get sufficient levels of choline.

As per a popular anecdotal evidence, the use of Piracetam can often times overly tax an individual’s cholinergic system. If enough choline is not present in your food, then there is a chance that you might be choline deficient.  This can be evidenced from any of the racetam nootropics being consumed on our platform, most are “commonly paired or stacked with” one choline source or another, see aniracetam with AlphaGPC, phenylpiracetam with the same, and pramiracetam here.

How to Cure a Piracetam Headache?

If an individual is suffering from a consistent headache while using Piracetam, they should first try adding choline to their diet (food). Secondly consider stacking your choline powder of choice with Piracetam, see alpha gpc dosage amount, and choline bitartrate dosage amount here or you can also try Centrophenoxine.

You should start by adding a small dose initially (250mg if alpha gpc for example) and then can slowly increase the dosage until your headaches are gone. If you did not notice any effects from adding additional choline at up to ~750mg, continuing to add more may not help. Again see the Piracetam page to determine what the most ‘common’ ratios are to get an idea as to where to draw your limit and call it quits. E.g. If you consume 4.8g of Piracetam with 250mg of Alpha-GPC you may not notice the helpful effects of adding choline to your stack, however if you consume 1.8g to 500mg of AlphaGPC–you might just notice that you don’t have a headache.  Generally consuming choline is also a good habit in and of itself and can act as a cognitive enhancer as well, see choline+inositol stack.

Choline stacks and Headaches

Taking Piracetam alone can cause headaches among some people and with the addition of choline, the headaches may stop, however for a few people the opposite is true. Taking Choline with Piracetam can cause headaches while taking Piracetam alone does not. In this case you could be “choline dominant” and your best course of action could be to cease supplementing choline. Many people read and feel as if it is absolutely essential to take a choline source with the Racetams and that’s just not true. If you don’t need it and your body is telling you it doesn’t need it via headaches, stop or take half the dose and observe the results.

Many users when adding choline experience depression, brain fog, lethargy or fatigue. Some research demonstrates a relationship between depression and large amounts of choline in the brain. Having said that, the opposite research is also available, so as of now, you may need to test what works and doesn’t for you. You can search for many supplement stacks which contain choline here, add a choline source you have and Piracetam on the compound search bar in the textbox on the left menu of the page and see what other’s are doing.

What to Do If the Headaches Persist

Additionally, the problem can be caused be something totally unrelated to Choline as well, are you hydrated enough?, are you getting enough restful-sleep?, do you have any chronic conditions?, stress? could it be the result of a interaction with other drugs or supplements?

Tracking these variables is key, and if you do have a condition and or are on other drugs, you can see if other’s on TrackMyStack have had the same symptoms as you — which can help in determining the cause of the problem. You can spend time researching and learning/biohacking yourself but don’t forget to visit a professional who may be able to diagnose the issue much quicker.

Generally, Piracetam is not common drug to supplement in the Western part of the world, chances are your health care professional will not know anything about it and ask you to get off of it right of the bat — as it is the safest thing for them to recommend. Consider taking another ‘supplement’ (Piracetam is a synthetic drug) for cognitive enhancement (if that is your goal). Another option is to utilize a Nootropic with a alternate mechanism of action such as Adrafinil.

Can You Develop A Tolerance For Nootropics With Regular Use?

nootropics toleranceSince the advent of nootropics in the 1960’s, supplements have helped us with preventative health and optimization in many areas. Nootropics were to treat diseases such as Alzheimer’s but are readily used for off-label purposes such as: enhancing things like, learning capacity, memory, and decision making.

There are additional advantages like helping protect the brain from oxidative damage and to enhance the health of billions of neurons. Furthermore, scientists keep studying ways for how Nootropics could be utilised daily to help patients with clinical conditions such as: ADHD, stroke and trauma patients and even cognitive degenerative conditions that come with age such as dementia.

A valid question thus arises which is, what are the certain tolerance levels for nootropics if used on a daily basis:

Can Supplementing Nootropics Cause A Tolerance Build Up

Tolerance is an issue with various pharmaceuticals and supplements whereby they turn out to be less efficient after some time. A major concern among new Nootropic supplement users’ is concerning the effectiveness of the supplement overtime. The nootropic Phenibut and Sulbutiamine come to mind when thinking of tolerance build ups.

Other’s are concerned about experiencing withdrawal after they stop using nootropics; and thus a dependency on the drug or supplement. This is not how most nootropics are made, and by definition, nootropics are suppose to help the brain whether it is for the short term or for immediate use. It is unlike the movie Limitless, where the drug NZT 48 when stopped causes the user to instantly go back to baseline IQ levels. Ayurvedic supplements such as Bacopa Monnieri for example take time to build up and generally “help” the brain and so stopping it suddenly has no withdrawal or immediate “dumbing” effects. Other smart drugs such as Modafinil or Adrafinil for example will peak in 3 hours and have a half life of about 15 hours, where after the effects are gone.

We urge you to explore our list of nootropic supplements as each one has a unique property.

Thus, your body can definitely build up tolerance for some Nootropic supplements. You may encounter indications of “mental addiction” to these supplements despite the fact that are no withdrawal symptoms or signs of physical addiction. For such Nootropics, there are various ways you can practice to make sure that you don’t develop a tolerance when using them.

We should also note that many of the Nootropics are planned for daily intake and are pretty much unlikely to build up a tolerance over the time. Some of the supplements will really have growing impacts that rise in concentration with regular doses, as mentioned above.

Nootropics such as Piracetam and Aniracetam are known to produce long term benefits as you consume them. This is because of the mechanism of action of Racetams generally.  Memory capacity and synaptic plasticity are two things which may be possible to increase over time. Similarly, nootropics with any kind of stimulant impact prompting high energy levels are more inclined to building up a tolerance and are ideal to be used occasionally or be cycled with some exceptions, e.g. Rhodiola Rosea.

What Is Tolerance?

Tolerance is basically when there is a diminished response to a drug being consumed as your body adapts to the continual presence of the drug or supplement in your system (note: this is different than Resistance). Overtime it turns increasingly difficult for the drug to act as intended. It can be discouraging when you notice that you don’t encounter the same advantages as you did when you first started.

In a few cases, to obtain the same effects as before, you may need to progressively increase your dose but that is not good advice under any circumstance (unless if approved by your physician), even with nootropics which have very low toxicity levels.tolerance to nootropics

There may be multiple reasons why tolerance develops, one of the reason could be that you may be producing less neurotransmitters or whatever substance the nootropic was increasing in your system, or it could be that you are already functioning at peak capacity.

The receptors of specific neurotransmitters may likewise turn out to be less sensitive implying that a greater amount of the neurotransmitter should be discharged all together for the same impact to take place.

There are various different tolerances which can occur, some are very long lasting, it may take months for the body to readjust. Caffeine is great example of such a tolerance. When you become dependent on caffeine; the receptors in your body begin to shrink and become less sensitive. The outcome is that you have to consume more caffeine so as to feel the same amount of energy and alertness. There are other sorts of tolerances which are brief and they balance out in a couple of hours after the supplement is consumed. An example is the stimulant Ephedrine. Ephedrine wears off much quicker than caffeine and it might actually last only 15 minutes.

Simple Way to Avoid Tolerance to Nootropics

The first step is to figure out if that specific nootropic has tolerance issues.  Then, if you have decided to take a Nootropic that has a high chance of leading to tolerance, you may take the similar route as bodybuilders and weightlifters when training: Cycling. A cycle is mainly a routine with phases of use (or training) trailed by phases of non-use (or not training).

So, perhaps as opposed to using a drug like Adrafinil for 30 days in a row, you may use it for a week, then cut back your intake for a week, after that use it 4 days with 3 days off. This is how a cycle works and it keeps the body from adjusting, the name of the game is random on and off days. Some anecdotal evidence suggests that for stimulants you may be able to take for 6 days on with 1 day (perhaps in the middle of the week) off for example, and still reap the same benefits or close to what you would if you had 4 days on and 3 off.

Certain nootropics which are particularly thought to act as stimulants are significantly more likely to bring about a level of tolerance in its users. They have to be cycled or utilized as part of a nootropic stack. These are a only a handful of nootropics that have tolerance issues.

Learn to Cycle and Stack Nootropics Properly

nootropics tolerance symptomsCycling and stacking nootropics needs to be done based on your goal. For instance, someone hoping to enhance their memory may have an altogether distinctive routine than a one hoping to improve brain health and defer the impact of age associated cognitive decline or Alzheimer’s.

First decide on your goal and after that discover which nootropics may help you accomplish it. Likewise find if there any extra nootropics that may potentiate the impacts of your drugs to further elevate the results. This can save you from taking too much of one drug as well and could possibly save you money, this experimentation can be made simpler by using TrackMyStack to determine when to cycle and the efficacy of certain nootropics.

Start with your primary nootropic agent, so for memory enhancement this may be Noopept or Phenylpiracetam. For Neuronal communication help, Huperzine or Centrophenoxine.  Make plans on cycling anything with stimulant like effects in and out every now and then. You can alternatively see if you get the same effect by picking a similar supplement as well, e.g. maybe Sulbutiamine to Rhodiola. Make sure you discuss all your choices with your primarily health care provider before switching back and forth and when in doubt, your better of without!

The Correct Modafinil Dose – 100mg, 200mg or 400mg Per Day?

modafinil dosageModafinil is a popular wakefulness promoting agent used by millions of patients everyday, though it started as a drug for narcolepsy, over time (reluctantly, see: Jet Lag syndrome) the FDA has allowed Cephalon to market it for other symptoms as well. It is a popular medication now used off-label to manage ADHD, aid in Weight loss and taken as  smart drug to boost mental capacity temporarily. The advantages of Modafinil are appealing and not easy to resist for those with the above aforementioned symptoms or goals.

When an individual decides to take Modafinil, they should first do their part and understand the procedure of how to carefully consume the drug. An important question one should ask before taking Modafinil for the first time is what’s the right dosage to avoid the side effects, 50mg, 100mg, 200mg, 400mg?

Modafinil’s Story

Modafinil was first developed at Lafon Laboratories in France in the late 1980’s. Modafinil was discovered after the invention of a chain of other chemicals categorized as Benzhydryl Sulfinyl. Most importantly, these included Modafinil’s precursor compound Adrafinil. Adrafinil was first found to improve wakefulness & alertness, later it was offered to treat people suffering from Narcolepsy in 1986 in France.

Modafinil was discovered as primary Metabolite and active component for Adrafinil. It was observed that Modafinil had lesser side effects & greater potency than its precursor. Although the use of Modafinil has grown exponentially in countries like UK and US, Adrafinil is used as a substitute to Modafinil as the drug is available without a prescription. Modafinil has been sold in United states from 1998, under the name Provigil, which is distributed by Cephalon Inc (The parent company of Lafon from 2001).

FDA, Modafinil & Dosage for ADHD

The FDA (Food and Drug Administration) has approved Provigil for treating shift work sleep disorder, narcolepsy and for hypopnea (Obstructive sleep apnea). Although some other medical conditions were found to benefit from Modafinil, FDA has failed to identify any additional benefits, even til this day.

Many studies were conducted and demonstrated how Modafinil can be used in treating ADHD in children and adults while carrying very few side effects, addiction, withdrawal or abuse when compared with similar drugs like Adderall or Ritalin. There were negative reactions in children aged 7 to 12 in about 20 of 100 patients, and for this reason the FDA Advisory committee in a vote of 12 to 1 decided that Cephalon would not be allowed to create the drug Sparlon (Modafinil in 345mg to 420mg doses) which was to be used for ADHD in children — which also happens to be the dose that Cephalon considered to be the “effective” dose in treating ADHD.

Off-Label and Recreational Modafinil Use

modafinil dose guideModafinil’s off-label use accounts for 90% of it’s sales (2004). Additional conditions that the drug Modafinil has been used include psychiatric and neurodegenerative disorders. This could also include treatment for Schizophrenia, Parkinson’s disease, bi-polar disorder, depression, medicine-influenced Fatigue or disease-related. ¹

Modafinil was discovered to produce a stabilized effect on mood, creating positive thoughts, well-being and elevated confidence. Modafinil can also help control the stress and can help reduce the symptoms of anxiety.

In the US, Provigil is also being used in treating atypical depression. This medical condition is noticeable in over-eating, hypersomnia, rejection sensitivity and low energy. Although as these are all off-label use cases, studies need to be performed so the FDA approve the use and dose required for treating such symptoms and conditions.

A good number of patients have found success taking Modafinil as a treatment for weight loss. Modafinil can result in advanced caloric expenditure and it can reduce the appetite by almost 38% less calories per day. Despite being used for many off-label purposes, it’s primary use continues to be that of a temporary cognitive enhancing agent.

A single dosage of Modafinil in the morning can give individuals a very sharp focus and eliminate urges for procrastination. To counter the effects of fatigue, the US Air Force has approved Modafinil to be used to increase alertness in personnel. Infact the late-founder of the company himself stated that Modafinil can be used as a alternative to coffee or amphetamine like substances when asked, “What else can this novel molecule be used for?” the CEO said.

Modafinil Dosage

provigil 50mg
Sample size of 31 patients consuming Provigil showed that 200mg followed by 50mg are the most common dose’s. Patients decided to go against mentioning if they had any condition, symptoms they were taking it for and it’s perceived effectiveness. We will be releasing a graph that will let us know the intent based on type of stack made, based on manually checking the stacks, most are for “Cognitive Enhancement”.

What dosage is right for you? Modafinil usually comes in two sizes, 100 mg and 200 mg. It’s the sales of 200mg out rank that of 100mg. For the most part your doctor will prescribe you the right dosage based on any medical conditions you may or may not have. Generally, if being taken for mental alertness, 25mg is a good starting point to determine if the desired effect is felt, if not you can increase your dose the day after. It should not matter if you are taking it on empty stomach or not. One easy way to tell if you have taken too much is a headache.

modafinil half life doseThe usual recommended dosage of Modafinil is 200mg, that is once in day often in the morning, some people claim it takes up to 3 hours to “kick in” (see graph below) and thus it may be advisable to take right upon waking as you will feel alert by the time you get to work.

The Best Modafinil Dose for You

First things first,  Modafinil is not for children, Children shouldn’t take it at all — especially given the disapproval by the FDA based on testing.

If you take Modafinil to counter shift work sleep disorder (Excessive drowsiness as a result of irregular work hours or schedule) then you should consider taking Modafinil just one to three hour right before the shift begins. Thus if you’re working for 8 hours, and even if the drug takes 2 hours to come into effect, based on the graph on the left you can see that the concentration in your blood remains high enough for you to get through your work effectively.

Some believe that Modafinil needs to be taken as per the body weight; however, only little evidence was there to prove that Modafinil is necessary only for an average user. Every supplement or drug has it’s pros and cons, a risk-reward ratio, and Modafinil is no different. Although Modafinil is considered to be a safe drug to take, few possible side effects may be associated when taken. Side effects such as nausea, nervousness, headaches, insomnia, dizziness, anxiety, back pain, rhinitis and diarrhea.

In placebo controlled studies, 8% of the individuals had to discontinue the drug due to adverse side effects. The most commonly noted side effect was headache. Patients on our site have noted that lowering the dosage and then taking it over 2 sessions reduced or removed headaches.  Please consult your doctor or a healthcare professional if any side effects do come up. When you have decided to take the drug start with small dose and observe for a week . If there are no negative effects you could increase the dosage. You can also learn more about Modafinils successor, Armodafinil, or Nuvigil here.


Does Taking Ashwagandha for Depression Work?

ashwagandha for depressionThe problem with taking traditional medicine for Depression are it’s side effects. Some of the side effects can be very adverse in nature. Depression strikes one in eight adolescents every year and it is estimated that up to 15 millions adults are suffering from depression. The condition doesn’t differentiate between gender or age.

Ashwagandha is scientifically known as Withania somnifera and is the answer to conventional medicine, however it is obviously not as potent as synthetic lab made drugs. Ashwagandha is a Sanskrit word and its literal meaning is “The smell of a horse”. It is said that people who consume Ashwagandha gain “Stallion like energy” and experience a stress-free mind. It is also considered one of the most powerful herbs in Ayurvedic medicine.

Ashwagandha belongs to the same family as the tomato. It has a plump shrub, yellow flowers and oval leaves. Because of its rejuvenating features, Ashwagandha is often called “The Indian ginseng”, although scientifically Ashwagandha and ginseng bare no resemblance at all. Ashwagandha is also referred to as winter cherry or poison Gooseberry.

Ashwagandha has Neuroprotective features which help in relieving stress and other symptoms of Depression. For centuries, Ashwagandha has been used as a remedy for depression, stress relief and insomnia. Known for its naturally wound healing abilities, the leaves of Ashwagandha are used to reduce swelling, heal joint pains and skin sores. There are countless ways people are utilizing Ashwagandha by incorporating it into their health regimen, click here to see Ashwagandha stacks to learn more.

The roots of Ashwagandha are used as an alternative treatment to depression and rightly so, ashwagandha has demonstrated to be effective when it comes to easing pain. Ashwagandha boosts sexual hormones and hence is also used as Aphrodisiac by some. See the breakdown below of it’s benefits:

Advantages of Ashwagandha

  1. Diminishes Anxiety and Stress-Induced Depression Stress-Induced Depression
  2. Help improve sleep and Insomnia
  3. May reduce fatigue and increases strength
  4. Shown to increase Athletic performance and encourage weight loss


  1. User May observe symptoms of Diuretic Effect

Ashwagandha, A natural remedy to counter Depression

Ashwagandha grows in parts of India and Northern Africa and has been used in Ayurvedic medicine to get relief from Depression for centuries.  The pungent, spiny root of Ashwagandha plant is collected and used to ease symptoms of many medical conditions ranging from Arthritis to Fibromyalgia. Ashwagandha is suggested often to boost sexual potency in males as well.

The additional benefit of Ashwagandha is that this plant is “earth grown” and natural, as opposed to synthetic and man made like Prozac or Lexapro. That’s not inherently good or bad, but generally you are less likely to experience any major side effects from a plant that has centuries worth of use behind it, but again this may come at the cost of not being as potent, but if you let it “build up” in your system and adhere to your stack, you should see benefits over time.

How does Ashwagandha work for Depression?

ashwagandha-root-dosage-for-depressionAshwagandha is recognized as an adaptogen, which implies that it is in the class of supplements which generally help your body deal with stress and normalize it, so for example, the Korean ginseng is another example. Using Ashwagandha for Depression stimulates the process of Adrenergic signaling to hinder the impact of chemicals connected with the symptoms of Depression like clonidine and reserpine.

It works in the same way as the supplement Yohimbe as well and helps improve the effects of compounds like SSRIs for depression.

Creating a de-stressed, relaxed feeling for body and mind, Ashwagandha replaces depression related symptoms such as hopelessness, gloom with peacefulness, mental clarity and feelings of lightness. When taken in large enough amounts, Ashwagandha acts as a mild sedative which helps to return sleep cycles to normal.

Other conditions Ashwagandha can also help with

Ashwagandha also helps with the medical conditions that are vaguely related to depressive symptoms. It’s likely that people who are diagnosed with depression, can also develop conditions which are not directly related to depression. For instance, chronic pain disorders are common for people who are diagnosed with depression. Ashwagandha is observed to ease the pain that is a caused by chronic conditions such as arthritis and fibromyalgia.

People take Ashwagandha to fight anxiety which works in the same way as GABAergic signaling. Ashwagandha is also known to lessen the impact of ADHD. The list of benefits that arise from Ashwagandha continue…

The rejuvenating features of Ashwagandha make it an immediate choice to treat Insomnia as well. Ashwagandha calms the central nervous system, relaxes the mind, eases stress and fights sleeplessness. Ashwagandha is used as a powder with the mixed in milk and honey for regulating sleep cycles in India. Other ways it is consumed in India is in a natural food called Chawanprash, a mixture of many natural herbs along with honey, grass-fed ghee and sesame oil, it is primarily given to kids as a general health aid, much like multi vitamins are given in the West.

How is Ashwagandha better than Prescription Anti-Depressants?

does-aswagandha-workAshwagandha is proven to be safe for regular consumption. Key neural structures are observed to improve with the use of Ashwagandha by hunting for destructive free radical molecules. It is also not known to be habit forming in anyway.

Side effects for people with auto-immune diseases related to high blood pressure, thyroid disorders or auto immune diseases may find their conditions aggravated by the root of the plant. The same warning goes to pregnant women, it is advised that you consult your healthcare provider if you have any of these pre existing conditions and still want to start supplementing on Ashwagandha. Might we add that tracking how you reach and recording your results on TrackMyStack will be useful to you, your family doctor and people around the world who can learn more about how well it is tolerated and what the effects are.

It is also advised that Ashwagandha not be taken along with the prescription sedatives or MAOIs as using Ashwagandha for Depressions acts as a natural MAO inhibitor by itself, increasing the levels of Serotonin and Dopamine. Ashwagandha should not be taken in conjunction with prescription drugs such as Moclobemide or Harmala.

What’s the right dose of Ashwagandha?

The right dose of Ashwagandha depends on the severity of the Depression symptoms. For most patients suffering from Depression, a strong and effective dosage of Ashwagandha would be about 6000 mg per day which is to be taken in 3 sittings. However, based on patient reported data on TrackMyStack, the most frequently dosed amount is 500mg, 1000mg and then 6000mg a day. The mentioned dose should be enough to relieve you of the effects of stress and this can only be done by you starting low and working your way up and recording how you react to it to determine the perfect dose for you. When taking a dose of 300-500mg per sitting, Ashwagandha can produce some visible results if the patient has very mild symptoms of depression.  If you would like to BUY Ashwagandha, click here.


The 5 Best and Most Popular Smart Drugs

smart drugsWith the arrival of the movie Limitless featuring a fictitious drug known as NZT-48 which exponentially improves human cognitive function beyond its present constraints, more individuals started toying with the possibility of a medication which could make them more intelligent. In spite of the fact that it sounds like a dream, researchers all over the globe have been attempting to create brain enhancing medication which can do just that.

As of this day, researchers have not created anything close to NZT, but we do have smart drugs (sometimes colloquially referred to as nootropics or used off-label as ‘smart drugs’) which we can use to enhance our focus temporarily in meaningful ways. Smart Drugs are being utilized far and wide by entrepreneurs, athletes, students, housewives, and poker players. They are utilized to enhance learning capacity, improve concentration and focus, enhance memory function, and written and verbal communication skills.

Not all who utilizes smart drugs will admit it; however, a recent survey done last January 2013, conducted by the prestigious science publication, Nature discovered widespread use. No less than one out of each five individuals surveyed reported utilizing drugs for “non-therapeutic reasons” with a specific end goal to enhance their memory, concentration, and focus. This article focuses on five of the most well-known smart drugs and compare their advantages, effects, negative effects, cost, and availability.

Prescription Smart Drugs

A difference amongst non-prescription and prescription medications is the potential they have for risk factors, including serious negative effects, and addiction. Prescription drugs are classified by the government in schedules as indicated by potential for abuse or addiction. In the realm of ‘smart drugs’, prescription medications such as Dexedrine, Ritalin, and Adderall have previously been widely used and reported.

These three medications are basic psychostimulants utilized fundamentally to improve concentration and focus for those who suffering from attention-deficit hyperactivity disorder and Attention deficit disorder. They provide tremendous value for certain patients, yet are not considered as the best all-around nootropic or smart drugs for improving cognition (for one because they are stimulants and not necessarily helping you heal or cure anything).

Modafinil a physician recommended drug used primarily to treat sleeping disorders such as narcolepsy, however, it continues to grow in popularity with sales figures now exploding primarily for off-label use such as cognitive enhancement1. It is a one of a kind drug that effectively functions to enhance a person’s wakefulness and belongs to a class of medications known as eugeroics.

Modafinil’s prevalence among nootropic users has earned it a spot in mainstream publications such as The Atlantic and Rolling Stone, CNN and ABC among others. Patients have reported that Modafinil not only gives them a feeling of mental alertness, but also enhances focus, motivation, and concentration. For some, efficiency increases, projects get completed start-to-finish, and remaining focused get’s much easier and starts to feel like the new norm. Almost sounds like a magical drug, we will explore its side effects and cost down the line below to provide a full picture of this drug:

  • It likely increases the user’s tolerance (an insensitivity to the medication) over time.
  • It can only be purchased with a prescription.
  • The costs of Modafinil, if not covered by insurance, can be over the top. For instance, the normal expense for a 30-day supply of generic Modafinil (30 pills) ranges between $550-$900.
  • Its potential negative effects which may exceed the benefits for a few clients, as it increases heart rate, anecdotal evidence points to getting agitated easily.

Because of these reasons, numerous smart drug clients choose to utilize a non-prescription based smart drug known as Adrafinil, which is the precursor to Modafinil.

What is Adrafinil?

smart pillsAdrafinil is a type of Nootropic drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. The reason behind this is that Adrafinil is legal in many places such as United States and has the ability to convert into Modafinil in the liver.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.


Noopept is nootropic supplement that is used to enhance learning capacity, memory, and concentration. It is known to be one of the most effective of all Nootropic supplements available on the market today.

What are the benefits of Noopept?

This supplement provides numerous benefits that affect the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. All of these actions combined are the reasons for the wide range of health benefits of this Nootropic drug.

The best known benefit of using this drug is that it significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, improved mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and improved thinking. You can compare it modafinil vs noopept here.


Choline is a substance that can be found in small amounts in various types of food products that we consume every day such as eggs. Choline functions as a direct precursor for the production of acetylcholine and it ensures that our body has adequate amounts of it.

What are the benefits of Choline?

Studies indicate that choline could enhance the effects of nootropic drugs, think of it a compound that strengthens the connections between neurons in the brain. Headaches are reported as the common side effect following the intake of nootropic drugs such as noopept or a racetam and consuming adequate amounts of Choline could relieve headaches. There are different supplements for choline such as: Choline Bitartrate, Alpha GPC, and Citi Choline.


A compound similar to Piracetam but considered much more potent. It works by binding to Acetylcholine receptor sites and then blocking their desensitization in order to increase the action potential of the neurons. Since it is very similar to the other Racetams, these comparisons may be worth looking at: Pramiracetam vs Piracetam, Pramiracetam versus Phenylpiracetam, and Pramiracetam vs. Oxiracetam. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

The Best Cognitive Enhancer or Smart Drug?

best smart drugsThese smart drugs are the most popular because of the fact that their advantages are easy to notice, some are very accessible in terms of price and availability. Each individual’s neurochemistry is distinctive, medicines and supplements may influence every individual in different way.

Among these five most well-known smart drugs, Piracetam is the oldest and safest and is the most well known cognitive booster. Numerous individuals start off with a Piracetam only stack and continue using it, failing to veer away. Others may add Citicoline or Alpha-GPC for synergistic reasons. It may be a slight process of trial-and-error or “biohacking” to determine the perfect dose and supplement/drug that works best for you, and remember to always consult with a professional before starting.