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Top 10 Most Effective Nootropic Supplements

nootropic supplementsWhat are the most effective nootropics that you can try? Nootropic supplements are also known as brain boosters and cognitive enhancers because of their ability to enhance mental performance and produce various positive effects to the brain. This includes improved speed of recall, heightened mental energy, improved short-term and long-term memory, enhanced mental clarity, and improved concentration.

These supplements may also improve the communication between neurons, thus enhancing their overall effectiveness and could promote a much healthier brain. This leads to better executive function, enhanced fluid intelligence, even more creative thought, and improved problem-solving. This means not all nootropics are taken “when you need a boost” but can be taken as a “vitamin” for neuroprotective reasons as well, think about it, if you can take a supplement for your body, why not to a larger extent for your brain as well.

There are a lot of clinical cases where some of these nootropics have helped and they include: attention deficit hyperactivity disorder (or ADHD), Parkinson’s disease, dementia, Alzheimer’s disease, as well as age specific cognitive decline. These benefits are the reason nootropics are being widely used by many people, for some, many times throughout the day. Below we list our top 10 supplements (& drugs) that may be of use to you. CONSULT YOUR HEALTH CARE PROVIDER BEFORE STARTING A REGIMEN WITH THESE. Consider this article a guide for beginners to get know about what’s out there and what their functions are.

There are many types of supplements available and this may be overwhelming for those looking to start. We wanted to make it easier by listing the top nootropic supplements in order of  most potent and most effective nootropics to “least” in our top 10. Least is in quotes because different supplements provide different benefits and have different side effects. By no means is this list comprehensive.


What is it? Modafinil is a smart drug that enhances energy levels and alertness – particularly in individuals who do not usually get enough sleep. User reports suggest that it gives them the desired mental energy boost that they need better than caffeine and other stimulants do. Hence, it has gotten to be well known for off-label use as a focus enhancer. Modafinil is clinically prescribed for individuals who suffer from sleep disorders such as obstructive sleep apnea, narcolepsy, among other sleep related conditions.

What are the benefits of Modafinil?

Modafinil has appeared to help individuals stay alert and focused, and additionally clear their mind, if they lack sleep or are sleepy. Researchers have effectively demonstrated a relationship between the utilization of this medication and retaining intellectual capacity in a sound state against variables such as absence of sleep. Be that as it may, not every one of them could associate Modafinil to a change in psychomotor capacity in human test subjects.

Regardless of its beneficial outcomes on concentration enhancement, focus and short-term memory, it hasn’t demonstrated huge enhancements in cases that concerned healthy adults with attention deficit hyperactivity disorder (or ADHD). Then again, the same condition found in kids appeared to benefit from the utilization of Modafinil to the same or more prominent degree as methylphenidate, the prescribed medication of choice for that purpose.


What is it?

Noopept is primarily used to enhance learning capacity, memory, and concentration. It is known to be one of the more potent cognitive enhancers and considered to be much more effective than most other synthetic nootropics especially when compared to other racetams.

What are the benefits of Noopept?

This supplement provides numerous benefits related to the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. It is thought that these combined actions are the reason for the wide range of cognitive benefits.

The most well-known benefit of this drug is it’s ability to significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, better mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and logic processing.


What is it?

Adrafinil is a drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. While as Modafinil is a controlled substance, Adrafinil is not, it metabolizes in the liver to form Modafinil. It can be a bit harsh on the liver for this very reason, so it is not advised to supplement this drug frequently and if done so, your liver enzyme levels should be monitored closely.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.


What is it?

Pramiracetam is an “advanced version” of Piracetam, it’s mechanisms of action too is very similar, it includes binding to Acetylcholine receptor sites in the brain and inhibiting their desensitization in order to increase the action potential of the neurons. Pramiracetam is one of the most powerful Nootropic supplements available. It has a very high bioavailability and is a fat soluble racetam and is noted to have long half-life.

What are the benefits of Pramiracetam?

Pramiracetam is known to be one of the “purer” Nootropics. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.


What is it?

Like pramiracetam, phenylpiracetam is also an “advanced and stronger” version of Piracetam. It contains a Phenyl molecule group attached to the original Piracetam and is known to be 60x more concentrated. This is why Phenylpiracetam provides better benefits may be a considered a step up from Piracetam.

What are the benefits of Phenylpiracetam?

Phenylpiracetam is known by its ability to help improve general tolerance to stress and cold. According to its user reviews, Phenylpiracetam could increase a person’s memory, focus, learning capacity, concentration, attention span, as well as mental energy. Additionally, it helps enhance physical performance, promotes intense focus, and improve workout recovery times.


effective nootropic supplementsWhat is it?

Sulbutiamine was originally synthesized in Japan, it is a synthetic version of Thiamine (or Vitamin B1) and is primarily used to enhance the overall energy levels of the brain. Sulbutiamine is not really considered a “true” Nootropic; however, it seems to go very well with other supplements that is why it is commonly stacked as part of a larger nootropic regimen.

What are the benefits of Sulbutiamine?

Sulbutiamine helps a person relax and promotes a feeling of general well-being. It improves the ability to concentrate and focus as well as enhancing attention span.


What is it?

Aniracetam belongs to the Ampakine family and is considered as a Racetam. It has the ability to provide mood boosting effects and reduces the levels of anxiety and stress and thus it is known as a potent anxiolytic. Aniracetam could greatly benefit those who suffer from depression, social anxiety, and other mood disorders.

What are the benefits of Aniracetam?

Some of the benefits of Aniracetam include improving focus, memory, and attention span. Aniracetam is not considered a CNS stimulant. However as a user it’s common to experience a initial boost of energy followed by feelings of relaxation. It is said this nootropic also increases memory Input and Output (I/O reference: Dave Asprey), meaning it helps with recall and speech fluency, however consider this anecdotal.

Huperzine A

What is it and what are its benefits?

Huperzine A is a herbal nootropic that is widely used by people for it’s ability to help inhibit an enzyme that degrades the learning neurotransmitter, acetylcholine. It is derived from a plant called Huperzia Serrata, which is abundant in China. Acetylcholine is one of the most important neurotransmitters in our body as it helps improve numerous cognitive functions and processes and enhances memory.


What is it and how does it work?

5-HTP is a chemical that is synthesized in the human body via L-Tryptophan and is converted into Serotonin inside the brain. Like acetylcholine, serotonin is also among the most important neurotransmitters since it is also responsible in promoting normal sleep patterns and regulates mood. It could also prevent over excitation of the brain and helps with better focus.


What is it?

Choline is a substance that can be found in small amounts in various types of food products that we consume every day. It is one of the basic components for any nootropic/cognitive enhancement supplement stack. Choline sources such as Choline Bitartrate, or CDP Choline function as a direct precursor for the production of Acetylcholine, thus it is important to supplement or consume it via food to make sure you have adequate levels.

What are the benefits of Choline?

Some studies show that choline could better potentiate the effectiveness of various nootropic drugs. Headache are considered to be a common side effect following the intake of racetams, a depletion of choline could be the culprit. Although it really does depends on your own biology, as it could be many other factors. Many will have you believe that you must supplement choline with any racetam and that is simply not the case. It should be consumed “as needed”, a little trial and error will you determine the right dose, but stay within the suggested dose on the label.

Based on TrackMyStack Users

Our users are taking the following nootropic supplements for cognitive enhancement, this report is updated live and can be accessed here to view the live version.
nootropic supplement report

Gender breakdown of the above report:

nootropic report by gender