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The Correct Modafinil Dose – 100mg, 200mg or 400mg Per Day?

modafinil dosageModafinil is a popular wakefulness promoting agent used by millions of patients everyday, though it started as a drug for narcolepsy, over time (reluctantly, see: Jet Lag syndrome) the FDA has allowed Cephalon to market it for other symptoms as well. It is a popular medication now used off-label to manage ADHD, aid in Weight loss and taken as  smart drug to boost mental capacity temporarily. The advantages of Modafinil are appealing and not easy to resist for those with the above aforementioned symptoms or goals.

When an individual decides to take Modafinil, they should first do their part and understand the procedure of how to carefully consume the drug. An important question one should ask before taking Modafinil for the first time is what’s the right dosage to avoid the side effects, 50mg, 100mg, 200mg, 400mg?

Modafinil’s Story

Modafinil was first developed at Lafon Laboratories in France in the late 1980’s. Modafinil was discovered after the invention of a chain of other chemicals categorized as Benzhydryl Sulfinyl. Most importantly, these included Modafinil’s precursor compound Adrafinil. Adrafinil was first found to improve wakefulness & alertness, later it was offered to treat people suffering from Narcolepsy in 1986 in France.

Modafinil was discovered as primary Metabolite and active component for Adrafinil. It was observed that Modafinil had lesser side effects & greater potency than its precursor. Although the use of Modafinil has grown exponentially in countries like UK and US, Adrafinil is used as a substitute to Modafinil as the drug is available without a prescription. Modafinil has been sold in United states from 1998, under the name Provigil, which is distributed by Cephalon Inc (The parent company of Lafon from 2001).

FDA, Modafinil & Dosage for ADHD

The FDA (Food and Drug Administration) has approved Provigil for treating shift work sleep disorder, narcolepsy and for hypopnea (Obstructive sleep apnea). Although some other medical conditions were found to benefit from Modafinil, FDA has failed to identify any additional benefits, even til this day.

Many studies were conducted and demonstrated how Modafinil can be used in treating ADHD in children and adults while carrying very few side effects, addiction, withdrawal or abuse when compared with similar drugs like Adderall or Ritalin. There were negative reactions in children aged 7 to 12 in about 20 of 100 patients, and for this reason the FDA Advisory committee in a vote of 12 to 1 decided that Cephalon would not be allowed to create the drug Sparlon (Modafinil in 345mg to 420mg doses) which was to be used for ADHD in children — which also happens to be the dose that Cephalon considered to be the “effective” dose in treating ADHD.

Off-Label and Recreational Modafinil Use

modafinil dose guideModafinil’s off-label use accounts for 90% of it’s sales (2004). Additional conditions that the drug Modafinil has been used include psychiatric and neurodegenerative disorders. This could also include treatment for Schizophrenia, Parkinson’s disease, bi-polar disorder, depression, medicine-influenced Fatigue or disease-related. ¹

Modafinil was discovered to produce a stabilized effect on mood, creating positive thoughts, well-being and elevated confidence. Modafinil can also help control the stress and can help reduce the symptoms of anxiety.

In the US, Provigil is also being used in treating atypical depression. This medical condition is noticeable in over-eating, hypersomnia, rejection sensitivity and low energy. Although as these are all off-label use cases, studies need to be performed so the FDA approve the use and dose required for treating such symptoms and conditions.

A good number of patients have found success taking Modafinil as a treatment for weight loss. Modafinil can result in advanced caloric expenditure and it can reduce the appetite by almost 38% less calories per day. Despite being used for many off-label purposes, it’s primary use continues to be that of a temporary cognitive enhancing agent.

A single dosage of Modafinil in the morning can give individuals a very sharp focus and eliminate urges for procrastination. To counter the effects of fatigue, the US Air Force has approved Modafinil to be used to increase alertness in personnel. Infact the late-founder of the company himself stated that Modafinil can be used as a alternative to coffee or amphetamine like substances when asked, “What else can this novel molecule be used for?” the CEO said.

Modafinil Dosage

provigil 50mg
Sample size of 31 patients consuming Provigil showed that 200mg followed by 50mg are the most common dose’s. Patients decided to go against mentioning if they had any condition, symptoms they were taking it for and it’s perceived effectiveness. We will be releasing a graph that will let us know the intent based on type of stack made, based on manually checking the stacks, most are for “Cognitive Enhancement”.

What dosage is right for you? Modafinil usually comes in two sizes, 100 mg and 200 mg. It’s the sales of 200mg out rank that of 100mg. For the most part your doctor will prescribe you the right dosage based on any medical conditions you may or may not have. Generally, if being taken for mental alertness, 25mg is a good starting point to determine if the desired effect is felt, if not you can increase your dose the day after. It should not matter if you are taking it on empty stomach or not. One easy way to tell if you have taken too much is a headache.

modafinil half life doseThe usual recommended dosage of Modafinil is 200mg, that is once in day often in the morning, some people claim it takes up to 3 hours to “kick in” (see graph below) and thus it may be advisable to take right upon waking as you will feel alert by the time you get to work.

The Best Modafinil Dose for You

First things first,  Modafinil is not for children, Children shouldn’t take it at all — especially given the disapproval by the FDA based on testing.

If you take Modafinil to counter shift work sleep disorder (Excessive drowsiness as a result of irregular work hours or schedule) then you should consider taking Modafinil just one to three hour right before the shift begins. Thus if you’re working for 8 hours, and even if the drug takes 2 hours to come into effect, based on the graph on the left you can see that the concentration in your blood remains high enough for you to get through your work effectively.

Some believe that Modafinil needs to be taken as per the body weight; however, only little evidence was there to prove that Modafinil is necessary only for an average user. Every supplement or drug has it’s pros and cons, a risk-reward ratio, and Modafinil is no different. Although Modafinil is considered to be a safe drug to take, few possible side effects may be associated when taken. Side effects such as nausea, nervousness, headaches, insomnia, dizziness, anxiety, back pain, rhinitis and diarrhea.

In placebo controlled studies, 8% of the individuals had to discontinue the drug due to adverse side effects. The most commonly noted side effect was headache. Patients on our site have noted that lowering the dosage and then taking it over 2 sessions reduced or removed headaches.  Please consult your doctor or a healthcare professional if any side effects do come up. When you have decided to take the drug start with small dose and observe for a week . If there are no negative effects you could increase the dosage. You can also learn more about Modafinils successor, Armodafinil, or Nuvigil here.

References

https://trackmystack.com/supplements-Modafinil-(Provigil)#experiences
http://www.ncbi.nlm.nih.gov/pubmed/24247883

The 5 Best and Most Popular Smart Drugs

smart drugsWith the arrival of the movie Limitless featuring a fictitious drug known as NZT-48 which exponentially improves human cognitive function beyond its present constraints, more individuals started toying with the possibility of a medication which could make them more intelligent. In spite of the fact that it sounds like a dream, researchers all over the globe have been attempting to create brain enhancing medication which can do just that.

As of this day, researchers have not created anything close to NZT, but we do have smart drugs (sometimes colloquially referred to as nootropics or used off-label as ‘smart drugs’) which we can use to enhance our focus temporarily in meaningful ways. Smart Drugs are being utilized far and wide by entrepreneurs, athletes, students, housewives, and poker players. They are utilized to enhance learning capacity, improve concentration and focus, enhance memory function, and written and verbal communication skills.

Not all who utilizes smart drugs will admit it; however, a recent survey done last January 2013, conducted by the prestigious science publication, Nature discovered widespread use. No less than one out of each five individuals surveyed reported utilizing drugs for “non-therapeutic reasons” with a specific end goal to enhance their memory, concentration, and focus. This article focuses on five of the most well-known smart drugs and compare their advantages, effects, negative effects, cost, and availability.

Prescription Smart Drugs

A difference amongst non-prescription and prescription medications is the potential they have for risk factors, including serious negative effects, and addiction. Prescription drugs are classified by the government in schedules as indicated by potential for abuse or addiction. In the realm of ‘smart drugs’, prescription medications such as Dexedrine, Ritalin, and Adderall have previously been widely used and reported.

These three medications are basic psychostimulants utilized fundamentally to improve concentration and focus for those who suffering from attention-deficit hyperactivity disorder and Attention deficit disorder. They provide tremendous value for certain patients, yet are not considered as the best all-around nootropic or smart drugs for improving cognition (for one because they are stimulants and not necessarily helping you heal or cure anything).

Modafinil a physician recommended drug used primarily to treat sleeping disorders such as narcolepsy, however, it continues to grow in popularity with sales figures now exploding primarily for off-label use such as cognitive enhancement1. It is a one of a kind drug that effectively functions to enhance a person’s wakefulness and belongs to a class of medications known as eugeroics.

Modafinil’s prevalence among nootropic users has earned it a spot in mainstream publications such as The Atlantic and Rolling Stone, CNN and ABC among others. Patients have reported that Modafinil not only gives them a feeling of mental alertness, but also enhances focus, motivation, and concentration. For some, efficiency increases, projects get completed start-to-finish, and remaining focused get’s much easier and starts to feel like the new norm. Almost sounds like a magical drug, we will explore its side effects and cost down the line below to provide a full picture of this drug:

  • It likely increases the user’s tolerance (an insensitivity to the medication) over time.
  • It can only be purchased with a prescription.
  • The costs of Modafinil, if not covered by insurance, can be over the top. For instance, the normal expense for a 30-day supply of generic Modafinil (30 pills) ranges between $550-$900.
  • Its potential negative effects which may exceed the benefits for a few clients, as it increases heart rate, anecdotal evidence points to getting agitated easily.

Because of these reasons, numerous smart drug clients choose to utilize a non-prescription based smart drug known as Adrafinil, which is the precursor to Modafinil.

What is Adrafinil?

smart pillsAdrafinil is a type of Nootropic drug that works very similarly to Modafinil. It works by boosting a person’s energy and promote mental alertness. As a matter of fact, many individuals use Adrafinil if their country does not legally approve the use of Modafinil. The reason behind this is that Adrafinil is legal in many places such as United States and has the ability to convert into Modafinil in the liver.

What are the benefits of Adrafinil?

It contains most of the benefits that Modafinil has and is primarily utilized as an energy-boosting and off-label Nootropic. It also has the ability to enhance cognitive performance and memory. Experts recommend to use Adrafinil on occasional basis in order to avoid the occurrence of side effects that may result following long-term use.

Noopept

Noopept is nootropic supplement that is used to enhance learning capacity, memory, and concentration. It is known to be one of the most effective of all Nootropic supplements available on the market today.

What are the benefits of Noopept?

This supplement provides numerous benefits that affect the synaptic activity of the brain. It works by stimulating the AMPA, Nicotinic, and NMDA receptor sites inside the brain. This leads to increased activity of certain neurotransmitters such as Acetylcholine, Glutamate, Serotonin, and Dopamine. All of these actions combined are the reasons for the wide range of health benefits of this Nootropic drug.

The best known benefit of using this drug is that it significantly increase working memory and memory consolidation. Other benefits of Noopept include improved reflexes, enhanced learning ability, improved mood, enhanced sensory perception, reduced anxiety, better overall mental performance, and improved thinking. You can compare it modafinil vs noopept here.

Choline

Choline is a substance that can be found in small amounts in various types of food products that we consume every day such as eggs. Choline functions as a direct precursor for the production of acetylcholine and it ensures that our body has adequate amounts of it.

What are the benefits of Choline?

Studies indicate that choline could enhance the effects of nootropic drugs, think of it a compound that strengthens the connections between neurons in the brain. Headaches are reported as the common side effect following the intake of nootropic drugs such as noopept or a racetam and consuming adequate amounts of Choline could relieve headaches. There are different supplements for choline such as: Choline Bitartrate, Alpha GPC, and Citi Choline.

Pramiracetam

A compound similar to Piracetam but considered much more potent. It works by binding to Acetylcholine receptor sites and then blocking their desensitization in order to increase the action potential of the neurons. Since it is very similar to the other Racetams, these comparisons may be worth looking at: Pramiracetam vs Piracetam, Pramiracetam versus Phenylpiracetam, and Pramiracetam vs. Oxiracetam. Some of its known benefits include enhancing learning capacity, increasing memory, focus, attention span, and concentration, and improving overall brain energy. Taking pramiracetam powder produces very little effects on anxiety and mood levels.

The Best Cognitive Enhancer or Smart Drug?

best smart drugsThese smart drugs are the most popular because of the fact that their advantages are easy to notice, some are very accessible in terms of price and availability. Each individual’s neurochemistry is distinctive, medicines and supplements may influence every individual in different way.

Among these five most well-known smart drugs, Piracetam is the oldest and safest and is the most well known cognitive booster. Numerous individuals start off with a Piracetam only stack and continue using it, failing to veer away. Others may add Citicoline or Alpha-GPC for synergistic reasons. It may be a slight process of trial-and-error or “biohacking” to determine the perfect dose and supplement/drug that works best for you, and remember to always consult with a professional before starting.

References:
¹ https://www.drugs.com/stats/provigil